Applications of the generalized least squares method proposed by Clarke [1] have been reported by various authors. However, no analysis of the convergence of the method has been published. This correspondence gives examples for which the method converges to false solutions.

Convergence properties of the generalized least squares method are analyzed. The method can be interpreted as optimization of a likelihood function. The number of local maximum points of the likelihood function is examined. It is shown that this number is influenced by the signal to noise ratio. This theoretical result is illustrated by numerical examples using plant measurements. It is also prove

The current study demonstrates through experiment, the effect of solid lubricant assisted minimum quantity cooling lubrication (MQCL) when turning tempered (~60 HRC) alloyed steel Uddeholm Caldie with cemented carbide tools on the process performance. In MQCL application, nanosized graphite nanoplatelets (GnP) solid lubricant powder was dispersed (0.2% vol.) in rapeseed oil based lubricant “ECOLUB

The maximum likelihood method of identification is a powerful tool for obtaining mathematical models of dynamic processes. To apply this method a loss function has to be minimized. The aim of the paper is an investigation of the local minimum points of this loss function for a common structure of a general form. If the loss function has more than one local minimum point, numerical problems can occ

The presence of graphite particles in gray cast iron commonly implies a good machinability, especially if compared to common steels. However, increasing industrial demands have resulted in a new interest for high-speed machining of these materials with higher performing tool materials than the traditionally used. Thus, the research presented in this paper focuses on evaluating the active tool wearThe presence of graphite particles in gray cast iron commonly implies a good machinability, especially if compared to common steels. However, increasing industrial demands have resulted in a new interest for high-speed machining of these materials with higher performing tool materials than the traditionally used. Thus, the research presented in this paper focuses on evaluating the active tool wear

Aim of the Study. To assess the frequency of and identify contributing factors to wound dehiscence after posterior sagittal anorectoplasty (PSARP) in children born with anorectal malformations (ARM). Methods. Ethical approval was obtained (DNR 2017/191). Charts of all children with anorectal malformations (ARM) reconstructed with PSARP, limited PSARP, or PSARVUP at a tertiary centre of paediatric

Objective: In the 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren’s syndrome (pSS), pre-existing lymphoma is not an exclusion criterion for pSS diagnosis, as in earlier criteria. We aimed to explore whether there are differences between pSS patients with and without pre-existing lymphoma at pSS diagnosis. Method: Patients with IC

To Ask for the King’s Permission to Marriage: Applications for Marriage between Relatives in Eighteenth Century Sweden. In early modern Western society regulations against incestuous relationships were primarily justified by religion, and kinship by blood and kinship by marriage were treated equally. In the seventeenth and eighteenth centuries Swedish law was among the strictest in these matters,

In some cases of tomography we can only gain high resolution projections of the object with only partial coverage, whereas only a small part of the object – a given Region of Interest (ROI) – is fully covered by high resolution projections. In such cases the structures outside the region of interest cause artefacts to appear in the reconstructed image and degrade the image quality of the tomogram.

Känslor och känsloyttringar kan förefalla vara allmänmänskliga företeelser, men forskning visar att den generella inställningen till känslor har skiftat mellan olika kulturer såväl som inom en och samma kultur över olika tidsperioder. Under medeltiden värderades exempelvis kontroll och förnuft högre än känslosamhet i det västerländska samhället, men från och med sent 1700-tal kom känslor och kärleResearch has shown that the general attitudes towards emotions have shifted between different cultures as well as within one culture over different periods. During the Middle Ages, for example, control and reason were considered more desirable human qualities than emotions in Western societies. However, from the late 1700s emotions and empathy were described with increasingly positive terms. From

Evidence suggests that research benefits from diversity, yet science is concentrated to a small group of countries. Diversity in physical therapy research has so far not been studied thoroughly, and this is the first study to map physical therapy research geographically. The objective was to study the frequency and methodological quality of physical therapy-related randomized controlled trials (RC

The algebraic regulator problem is formulated and solved in a transfer matrix setting. It is shown that, provided the closed loop system disregarding disturbances is stable, a necessary and sufficient condition for output regulation to take place is that the open loop path consisting of the plant and compensator in cascade, contains a suitably defined internal model of the environment. The disturb

The vitamin D receptor (VDR) has been proposed as a candidate gene for several musculoskeletal phenotypes. However, previous results on the associations between genetic variants of the VDR with muscle strength and falls have been contradictory. The MrOS Sweden survey, a prospective population-based cohort study of 3014 elderly men (mean age 75 years, range 69–81) offered the opportunity to further

In this paper we study coupled dynamical systems and investigate dimension properties of the subspace spanned by solutions of each individual system. Relevant problems on collinear dynamical systems and their variations are discussed recently by Montenbruck et. al. in [1], while in this paper we aim to provide a unified analysis to derive the dimensional-invariance principles for networked coupled

During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem

Nanowires offer remarkable opportunities for realizing new optoelectronic devices because of their unique fundamental properties. The ability to engineer nanowire heterostructures with large bandgap variations is particularly interesting for technologically important broadband photodetector applications. Here we report on infrared photodetectors based on arrays of InP nanowires with embedded InAsP

While the contemporary academic discourse regards innovation as an inherent feature of infrastructure public‒private partnerships (PPPs), the conceptual link between infrastructure PPPs and innovation is narrowly understood. While most existing studies conceptualize the innovation processes and effects within the context of PPP projects, we argue that the relevance of innovation in infrastructure