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Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the association between the methylation profile of the PPARGC1A gene promoter gene in leukocytes with insulin secretion/sensitivity indexes in normoglycemic women. A standard oral glucose tolerance test (OGTT) and an abbreviated

In this chapter, an individual life story of a shipyard blacksmith is the point of departure for discussing elderly men’s labour market experiences. This story, which can be summarized as occupational continuity in a turbulent period, is in line with an optimistic view of the situation of elderly men in an era of profound changes in the technology and organization of work, is contrasted against th

Research in the field of historical demography and related areas have in recent decades made increasing use of longitudinal population databases. This research has mainly focused on rural populations before 1900. This book belongs to a movement that seeks to bridge the gap in historical demography by adding urban populations from the twentieth century. The book is made up of individual chapters re

In this chapter, we describe the city of Gothenburg in the first half of the twentieth century. The chapter is mainly based on reviews of official statistics and previous research, and starts with an account of how the size and composition of Gothenburg’s population changed. We establish that the city doubled in population between 1910 and the end of the Second World War, partly as a consequence o

In this chapter, we investigate income differentials across the life cycle at the individual and household levels. The main contribution is to compile basic patterns of age–earnings relationships by sex, occupation and family situation. At the individual level we find age–earnings patterns similar to those observed for the period following the Second World War, for example in the seminal works of

This chapter deals with labour mobility and labour market segmentation in Gothenburg in 1915–1943. For this purpose, the Gothenburg Population Panel offers unique research opportunities as it includes information about employers, as well as occupation and source of income. Thus, it is possible to capture labour mobility in a wide sense, not only distinguishing between changes of employer and occup

In this final chapter, we revisit the two main questions raised in chapter 1. The first question concerned how to characterize the typical life cycle and identify typical markers associated with transitions between phases in life in Gothenburg in the first half of the twentieth century. Investigations of the transition from youth to adulthood and from mature age to retirement shows relatively prol

Background: Electrodermal hyporeactivity has been proposed as a marker of suicidal risk. The EUDOR-A study investigated the prevalence of electrodermal hyporeactivity among patients with depression and its association with attempted and completed suicide. Methods: Between August 2014 and March 2016, 1,573 in- and outpatients with a primary diagnosis of depression (active or remission phase) were r

Doubling in size since the 1970s, the aging needs of the African immigrant population are not fully understood. This qualitative study examined experiences of aging and retirement planning for African immigrant older adults in the United States (U.S.). Specifically, it explored the factors, processes, and ultimate decision of where these older adults planned to retire. Secondary analysis of semi-s

Few studies have investigated the relationships between organic food consumption, dietary patterns, monetary diet cost, health, and the environment. To address these issues, a consortium of French epidemiologists, nutritionists, economists, and toxicologists launched the BioNutriNet project in 2013. In 2014, an FFQ documented the usual organic and nonorganic (conventional) food consumption of appr

Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism enhanced by opsonization, where typically, more bound antibodies trigger a stronger phagocyte response. Here, we show that Spike-specific antibodies,

BACKGROUND AND AIMS: The severity of the atherosclerotic burden is hardly quantifiable in subjects at high cardiovascular (CV) risk under intensive pharmacological therapy. Several molecules have been proposed as circulating biomarkers of atherosclerosis, but none has emerged as clinically meaningful.METHODS: Circulating proteins involved in inflammation, plaque remodeling, smooth muscle cell migr