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Purpose: Most patients with prostate cancer treated with androgen receptor (AR) signaling inhibitors develop therapeutic resistance due to restoration of AR functionality. Thus, there is a critical need for novel treatment approaches. Here we investigate the theranostic potential of hu5A10, a humanized mAb specifically targeting free PSA (KLK3). Experimental Design: LNCaP-AR (LNCaP with overexpres

As an adaptive response to hypoxic stress, aggressive tumors rewire their metabolic phenotype into increased malignant behavior through extracellular lipid scavenging and storage in lipid droplets (LD). However, the underlying mechanisms and potential lipid source retrieved in the hypoxic tumor microenvironment remain poorly understood. Here, we show that exosome-like extracellular vesicles (EV),

I boken görs en analys av intervjuer med personer som lämnat ett trossamfund utan att gå med i ett annat. De intervjuades livsberättelser presenteras och belyses utifrån aktuell religionssociologisk och samhällsvetenskaplig teoribildning.

Introduction: Thrombocytopenia has been identified as an independent risk factor for retinopathy of prematurity (ROP), although underlying mechanisms are unknown. In this study, the association of platelet count and serum platelet-derived factors with ROP was investigated. Methods: Data for 78 infants born at gestational age (GA) <28 weeks were included. Infants were classified as having no/mild R

Following preterm birth, serum levels of insulin-like growth factor 1 (IGF-1) decrease compared to corresponding in utero levels. A recent clinical trial indicated that supplementation with recombinant human (rh) IGF-1/rhIGF-binding protein 3 (rhIGF-1/rhIGFBP-3) prevents severe intraventricular hemorrhage (IVH) in extremely preterm infants. In a preterm rabbit pup model, we characterized endogenou

Novel coronavirus disease (COVID-19) is spreading rapidly and creating a huge economic, social and public health challenge worldwide. Although currently an effective vaccine is ready, its distribution is limited, and hence the only currently available lever to reduce transmission is to identify and isolate individuals who are contagious. Thus, testing for SARS CoV-2 has a paramount importance. How

Aims: To compare the prevalence of facial pain and headache across various regions in Sweden. Methods: This study involved a comparison of cross-sectional questionnaire studies over a period of 10 years including 128,193 individuals and assessed facial pain, pain on function, and headache. Participants included (1) all Public Dental Service patients aged 16 to 90 years in Västerbotten (n = 57,283)

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. Methods: We

This collaborative statement from the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society describes the current status of mobile health technologies in arrhythmia management. The range of digital medical tools and heart rhythm disorders that they may be applied to and clinical decisions that may

BACKGROUND: The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial. METHODS: In this international, multicenter, prospective, randomized, open-label trial, men with prostate cancer and concomitant atherosclerotic cardiovascular disease were

BACKGROUND: ECG abnormalities are associated with adverse outcomes in the general population, but their prognostic significance in severe mental illness (SMI) remains unexplored. We investigated associations between no, minor, and major ECG abnormalities and fatal cardiovascular disease (CVD) among patients with SMI compared with controls without mental illness. METHODS AND RESULTS: We cross-linke

Camera sensor networks, mainly with surveillance cameras, are growing in size and complexity. Storage space is the prime resource in such systems but current surveillance setups are still very much centralized and limited in resources due to cost and security constraints. Allocating the correct amount of storage to each camera sensor considering their large difference in characteristics and video

Antibody binding to cell surface proteins plays a crucial role in immunity, and the location of an epitope can altogether determine the immunological outcome of a host-target interaction. Techniques available today for epitope identification are costly, time-consuming, and unsuited for high-throughput analysis. Fast and efficient screening of epitope location can be useful for the development of t

A method of fabricating pure germanium dioxide hollow-core fibers is introduced. The inner diameter of the fiber is 0.8 mm. Its transmission loss is 1.23 dB/m at 10.6 μm. The mechanism of transmitting CO2 laser radiation through the fiber as well as the transmitting performance are discussed. Applications of these fibers are also envisaged.

Natural lifetimes were measured by time-resolved observation of laser-induced fluorescence. Free Ce, Ce+, and Ce++ particles were obtained in a laser-produced plasma. Lifetimes were measured for eight levels of singly ionized cerium, as well as for nine levels of doubly ionized cerium. The lifetime data were compared with previously published experimental and theoretical results.

The measured radiative lifetime of Rydberg states of neutral lead were compared with the values obtained by multichannel quantum defect theory (MQDT). The radiative lifetime of Rydberg state of Pb1 was calculated using laser abalation technique and time resolved laser spectroscopy. MQDT parameters were found by experimental estimation of energy levels and the theoretical lifetime was evaluated usi

Multichannel-quantum-defect theory (MQDT) analyses were carried out for the J=0, 1, and 2 even-parity Rydberg series level of Pb I. The MQDT wave functions of each level were obtained. With the wave functions and employing the experimental lifetimes and Landé (gJ) factors measured previously, the theoretical lifetimes of J=0,1, and 2 levels were evaluated as well as the theoretical gJ factors of J

Mid-IR polarization spectroscopy (IRPS) and laser-induced fluorescence were applied for detection of CH4 and ethane in 1 atm cold flows and flames. The dependence of IRPS and IRLIF signal of CH4 on different buffer gases, including He, Ar, N2, and CO2 were studied. Simultaneous measurements of IRPS and IRLIF signals allowed a direct comparison of the two techniques. IRPS was superior in detection

Technical developments for the detection of formaldehyde using laser-induced fluorescence were presented. A technique for simultaneous detection of formaldehyde and OH using one laser system was presented. The combined formaldehyde and OH technique was applied in laboratory flames and a small spark-ignition engine. The iodine measurement was performed in a cell using the second harmonic of the sin