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Discovery of Teneurins

Teneurins were first discovered and published in 1993 and 1994, in Drosophila melanogaster as Ten-a and Ten-m. They were initially described as cell surface proteins, and as pair-rule genes. Later, they proved to be type II transmembrane proteins, and not to be pair-rule genes. Ten-m might nonetheless have had an ancestral function in clock-based segmentation as a Ten-m oscillator. The turn of the

Understanding the complex metallic element Mn. II. Geometric frustration in β−Mn, phase stability, and phase transitions

In the preceding paper [D. Hobbs, J. Hafner, and D. Spišák, Phys. Rev. B 68, 014407 (2003)], we have started an ab initio spin-density-functional study of the complex structural and magnetic phase behaviors of Mn by a detailed investigation of α−Mn. It was shown that the complex crystalline and noncollinear antiferromagnetic structures are the results of the conflicting tendencies to maximize simu

Towards Robust Linguistic Analysis using OntoNotes

Large-scale linguistically annotated corpora have played a crucial role in advancing the state of the art of key natural language technologies such as syntactic, semantic and discourse analyzers, and they serve as training data as well as evaluation benchmarks. Up till now, however, most of the evaluation has been done on monolithic corpora such as the Penn Treebank, the Proposition Bank. As a res

Understanding the complex metallic element Mn. I. Crystalline and noncollinear magnetic structure of α−Mn

Manganese is an element with outstanding structural and magnetic properties. While most metallic elements adopt a simple crystal structure and order magnetically—if at all—in a simple ferromagnetic or antiferromagnetic configuration, the stable phase of manganese at ambient conditions, paramagnetic α−Mn, adopts a complex crystal structure with 58 atoms in the cubic cell. At a Néel temperature of T

ICARUS -- An Extensible Graphical Search Tool for Dependency Treebanks

We present ICARUS, a versatile graphical search tool to query dependency treebanks. Search results can be inspected both quantitatively and qualitatively bymeans of frequency lists, tables, or dependency graphs. ICARUS also ships with plugins that enable it to interface with tool chains running either locally or remotely.

Exploring links between witnessed and instigated workplace incivility

PurposeThe purpose of this paper is to explore how witnessing workplace incivility from coworkers and supervisors relates to instigating incivility toward others. A further aim was to investigate if witnessed incivility is indirectly related to instigated incivility via perceived stress and low job satisfaction. An additional aim was to study if control, social support and job embeddedness moderat

The discoidin domain family revisited : new members from prokaryotes and a homology-based fold prediction

Members of the discoidin (DS) domain family, which includes the C1 and C2 repeats of blood coagulation factors V and VIII, occur in a great variety of eukaryotic proteins, most of which have been implicated in cell-adhesion or developmental processes. So far, no three-dimensional structure of a known example of this extracellular module has been determined, limiting the usefulness of identifying a

Novel tenascin variants with a distinctive pattern of expression in the avian embryo

Previous studies have shown that several forms of the glycoprotein tenascin are present in the embryonic extracellular matrix. These forms are the result of alternative splicing, which generates tenascin variants with different numbers of fibronectin type III repeats. We have used degenerate primers and PCR to isolate a novel tenascin exon from an avian genomic library. Genomic clones contained a

Energy and virtuality scale dependence in quark and gluon jets

We discuss some important issues concerning multiplicities in quark and gluon jets in e+e- annihilation. In QCD the properties of a jet in general depend on two scales, the energy and virtuality of the jet. Frequently theoretical predictions apply to a situation where these scales coincide, while for experimental data they are often different. Thus an analysis to extract e.g. the asymptotic multip

Tenascin-C expression by fibroblasts is elevated in stressed collagen gels

Chick embryo fibroblasts cultured on a collagen matrix exert tractional forces leading to the contraction of unrestrained, floating collagen gels and to the development of tension in attached, restrained gels. On a restrained, attached collagen gel the fibroblasts synthesize large quantities of tenascin-C, whereas in a floating, contracting gel tenascin-C synthesis is decreased. This regulation of

Nerve-dependent and -independent tenascin expression in the developing chick limb bud

The extracellular matrix protein, tenascin, appears in a restricted pattern during organ morphogenesis. Tenascin accumulates along developing peripheral nerves as they leave the spinal cord and enter the limb mesenchyme (Wehrle and Chiquet, Development 110, 401-415, 1990). Here we found that most but not all tenascin deposited along growing nerves is of glial origin. By in situ hybridization with

Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary