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In-depth genetic analysis of sclerosing epithelioid fibrosarcoma reveals recurrent genomic alterations and potential treatment targets

PURPOSE: Sclerosing epithelioid fibrosarcoma (SEF) is a highly aggressive soft tissue sarcoma closely related to low-grade fibromyxoid sarcoma (LGFMS). Some tumors display morphological characteristics of both SEF and LGFMS, so called hybrid SEF/LGFMS. Despite the overlap of gene fusion variants between these two tumor types, SEF is much more aggressive. The present study aimed to further characte

hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner

Inhibition of the Akt kinase activates HPV16 late gene expression by reducing HPV16 early polyadenylation and by activating HPV16 late L1 mRNA splicing. We identified 'hot spots' for RNA binding proteins at the early polyA signal and at splice sites on HPV16 late mRNAs. We observed that hnRNP L was associated with sequences at all HPV16 late splice sites and at the early polyA signal. Akt kinase i

Circular Business Models in the Mobile Phone Industry

The circular economy offer opportunities to reduce resource use and waste whilst providing business opportunities. This is also true in the mobile phone industry that has been characterised by high rates of product obsolescence. The emergence of the smart phone has changed the landscape, making repair, refurbishment and resell attractive to businesses and consumers. Moreover, emerging modular phon

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When literature, conflict and memory are linkaged one to another. This is the main intention that this article brings about into the centre of discussion. Written in a form of personal reflection, then followed by a deeper discussion on the main topic, I address the notion of so-called constructed memory in the context of understanding the Indonesian literature as the impact of the 1965 conflict o