In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis,

By computers imulationso f differentf lightr outesf or springm igratingK nots Calidris canutusp, otentialo rientationa'ld angerz ones' werer evealedi n the equatora rea and northo f the Arcticc ircle.A n evaluationo f the availabilityo f directionailn formation duringm igratoryf lightsd emonstratedth e potentialh azardso f crossingt hese danger zones. Investigationso f the directionalc onsequences

onthly averages of ecosystem respiration (ER), gross primary production (GPP) and net ecosystem exchange (NEE) over Scandinavian forest sites were estimated using regression models driven by air temperature (AT), absorbed photosynthetically active radiation (APAR) and vegetation indices. The models were constructed and evaluated using satellite data from Terra/MODIS and measured data collected at

Objective: High levels of sex steroid hormones and prolactin have been suggested to enhance breast cancer development. Low levels of SHBG may indicate high levels of (bio-available) steroid hormones. The present study investigates whether high levels of sex steroid hormones and prolactin, and/or low levels of SHBG, are associated with high breast cancer risk. Methods: Blood samples were collected

In guinea-pig isolated airways, nonadrenergic, noncholinergic (NANC) neural responses converge towards a similar level of smooth muscle tone, via a contraction when the tone is low prior to stimulation, and via a relaxation when the tone is high prior to stimulation. We wanted to assess the effect of simultaneous parasympathetic activation on these converging NANC responses, with and without the a

The gamma decay of excited states in the N = Z odd-odd nucleus Rb-74 has been observed for the first time. The reaction Ca-40(Ca-40,alpha pn)Rb-74 at 128 MeV beam energy was used. The ground state rotational band can be interpreted as being formed from the T = 1 isobaric analog states of Kr-74 with pairing correlations based on T = 1, M(T) = 0 neutron-proton pairs. At higher rotational frequency,

The possibility of recording changes in electroencephalography potentials following perception of sound was reported several decades ago. The recent expanding research on auditory cortical event-retated potentials (AERPs) for assessing sound discrimination abilities in children and infants has indicated that several methodological issues need to be addressed before it can be implemented in clinica

For the creation of sub-micron emulsions in fluids of low viscosity the high pressure homogenizer (HPH) is usually chosen. One way of obtaining deeper knowledge of exactly what happens in the active region is to visualize it. In this work, a drop deformation and break-up visualization system based on a modified Particle Image Velocimetry (PIV) system is described. The system reproduces the gap in

Polysiloxanes with pendant benzimidazole units have been prepared by free radical thiolene coupling reactions of 2-(2-benzimidazolyl)ethanethiol and vinyl-functional polysiloxanes. The latter polymers were prepared by anionic ring opening copolymerization of 1,3,5,7-tetramethyl-1,3,5,7-tetravinylcyclosiloxane and 1,3,5-hexamethyleyclosiloxane. Copolymers with different degrees of benzimidazole fun

Based on morphological analyses, extant members of the order Crocodylia are divided into three families, Alligatoridae, Crocodylidae, and Gavialidae. Gavialidae includes one species, the gharial, Gavialis gangeticus. In this study we have examined crocodilian relationships in phylogenetic analyses of seven mitochondrial genomes that have been sequenced in their entirety. The analyses did not suppo

Correlations of the difference between the measured and calculated mass of neighbouring nuclei obtained from different nuclear compilations are studied. The autocorrelation function is found to be, to a good approximation, model independent. The result is well described by a semiclassical theory that assumes the existence of a contribution to the nuclear mass associated with a chaotic motion of th

This article investigates the performance of five commonly used density functionals, B3LYP, BP86, PBE0, PBE, and BLYP, for studying diatomic molecules consisting of a first row transition metal bonded to H, F, Cl, Br, N, C, O, or S. Results have been compared with experiment wherever possible. Open-shell configurations are found more often in the order PBE0 > B3LYP > PBE similar to BP86 > BLYP. Ho

Background There is growing evidence that erectile dysfunction is a sentinel for future coronary artery disease. Recently published studies have shown signs of impaired coronary endothelial function in patients with erectile dysfunction, without clinical cardiovascular disease and diabetes. We evaluated the magnitude of coronary vasodilatory dysfunction in men with erectile dysfunction, as compare

We used a recombinant lentiviral vector (rLV) for gene delivery of GDNF to the striatum, and assessed its neuroprotective effects in the intrastriatal 6-hydroxydopamine (6-OHDA) lesion model.The level of GDNF expression obtained with the rLV-GDNF vector was dose-related and ranged between 0.9-9.3 ng/mg tissue in the transduced striatum, as determined by ELISA, and 0.2-3.0 ng/mg tissue were detecte