A label free biosensor for direct detection of inorganic phosphate based on potential-step capacitance measurements has been developed. The high-affinity Pho84 plasma membrane phosphate/proton symporter of Saccharomyces cerevisiae was used as a sensing element. Heterologously expressed and purified Pho84 protein was immobilized on a self-assembled monolayer (SAM) on a capacitance electrode. Change

The male: female (sex) ratio is of considerable importance in understanding population dynamics of species. A null hypothesis was tested that the male:female (sex) ratio of Carabus species does not differ measurably when entire seasons are considered, but may differ considerably over shorter periods, indicating differences in annual rhythms between the sexes. The sex ratios in nine Carabus species

Vad är en fabrik? Med industrisamhällets avveckling följer en ny ruinromantik. Över hela Västvärlden blir slitna tegelfasader och rostbruna maskinhallar till nya utflyktsmål, gallerier, caféer eller trendiga arbetsplatser. Samtidigt skapas nya industrilokaler, där besökarnas intryck är lika viktiga som den tillrättalagda produktionen. Är det bilar eller upplevelser som tillverkas här? Industrial

Popular Abstract in Swedish Titelns första del är ett Walter Benjamin-citat som bildar utgångspunkt och förklaras i avhandlingens första kapitel. Tidigare forskning, samlat till fyra tematiska områden, presenteras: drottning Kristina själv och hennes lärdom, bibliotekarierna och de andra lärda, det kungliga biblioteket i Stockholm och samlingen i Rom. Bibliotekets tidiga historia, hur det kommer tThis study examines how the Latin manuscript collection of Queen Christina of Sweden was formed, what function it served for the queen and for others, and how various attempts to impose order on it reflect different epistemological traditions. A recurring theme of the study is the creation of order and the title, The Mild Boredom of Order, a quotation taken from an essay on book collecting by Walt

A brief historical background to the currently ascend- ing interest in evolutionary and coevolutionary theory is sketched, and the concept of society–nature coevolution is positioned in this broader field. The significance of society–nature coevolution- ary pathways for transition to sustainability is highlighted with Schellnhuber’s heuristic ‘theater world’ for representing paradigms of sustainab

A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22.33, 2q35, 20q11.22-q12 and 14q24.3. Moreover, six additional susceptibility loci were associated with the disease only among Italians. The p

Background Overexpression of human epidermal growth factor receptor 2 (HER2) or amplification of its gene is a prognostic factor in primary breast cancer and a predictor for tamoxifen treatment efficacy in oestrogen receptor (ER) positive disease. In the present study we explored a defined cohort of breast cancer patients included in a randomised trial in order to assess prognostic and tamoxifen t

Global cerebral ischemia following cardiac arrest is associated with increased cerebral vasoconstriction and decreased cerebral blood flow, contributing to delayed neuronal cell death and neurological detriments in affected patients. We hypothesize that upregulation of contractile ETB and 5-HT1B receptors, previously demonstrated in cerebral arteries after experimental global ischemia, are a key m

The number of negative eigenvalues of self-adjoint Laplacians on metric graphs is calculated in terms of the boundary conditions and the underlying geometric structure. This extends and complements earlier results by Kostrykin and Schrader (2006 Contemp. Math. 415 201-25).

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemer

This paper presents a low voltage continuous-time delta-sigma modulator (DSM) intended for the receiver of an ultra-low-power radio. The DSM features a 2nd-order loop filter implemented with a single operational amplifier to reduce the power consumption. Furthermore, a 4-bit quantizer is used to achieve high resolution while keeping the sampling frequency low. The quantizer is realized using the s

Food security can be defined as stable access to food of good nutritional quality. In Sub Saharan Africa access to food is strongly linked to local food production and the capacity to generate enough calories to sustain the local population. Therefore it is important in these regions to generate not only sufficiently high yields but also to reduce interannual variability in food production. Tradit

This paper investigates the model reduction problem for mean square stable discrete time Markov jump linear systems. For this class of systems a balanced truncation algorithm is developed. The reduced order model is suboptimal, however the approximation error, which is captured by means of the stochastic L2 gain, is bounded from above by twice the sum of singular numbers associated to the truncate

A measurement is presented of the cross section for the production of a W boson with one or two jets, of which at least one must be a b-jet, in pp collisions at root s = 7 TeV. Production via top decay is not included in the signal definition. The measurement is based on 35 pb(-1) of data collected with the ATLAS detector at the LHC. The W + b-jet cross section is defined for jets reconstructed wi

Popular Abstract in Swedish När vi äter socker frisätter kroppen hormonet insulin från specifika beta-celler i bukspottskörteln för att förmå muskelceller och fettceller att ta upp sockret från blodet och därmed återställa blodets sockerbalans. Vid övervikt blir dessa vävnader resistenta mot insulinets verkan vilket leder till att sockret stannar kvar i blodet. Detta vill kroppen undvika då en förThere are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i

Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. The research presented in this thesis has focused on elucidating a possible involvement of the human protein alpha-1-microglobulin in the defence against pathological oxidation.