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Circulating levels of the astrocytic marker S100B have been associated with risk of neuropsychiatric or neurological disorders. However, reported effects have been inconsistent, and no causal relations have yet been established. We applied two-sample Mendelian Randomization (MR) on the association statistics from genome-wide association studies (GWAS) for circulating S100B levels measured 5-7 days
This paper proposes an alternative semi-analytical Fourier modal method adapted for general periodic anisotropic gratings made of dielectrics with moderate to low index profiles corresponding to materials ranging from conventional dielectric 3D printing materials to ceramic materials. The proposed method is closely related to the classical rigorous coupled wave analysis built on scattering matrice
This work investigates the cryogenic performance of InAs-based vertical nanowire ferroelectric field-effect transistors (VNW-FeFETs) with hafnium zirconium oxide (HZO) as the ferroelectric gate dielectric. Measurements at 300 K and 14 K reveal a 25% increase in memory window, from 560 mV at room temperature to 700 mV at 14 K, indicating enhanced polarization stability at low temperatures while als
BACKGROUND: Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated. Access to evidence-based obesity treatment is limited, leading to increased obesity severity and related complications. Barriers to obesity treatment include socioeconomic disparities, limited clinician training, stigma
Contraction scour at bridges occurs when the flow cross section is reduced by the bridge structure. In this study, a model was developed to predict the equilibrium contraction scour depth at a bridge using readily available data. This approach can be applied to assess contraction scour on a catchment scale in the initial phase of a study. The model was validated using laboratory measurements, achi
Background and purpose: Stereotactic radiosurgery (SRS) requires high positional accuracy to safely deliver large doses. This study evaluated an integrated surface- and image-guided radiotherapy (SGRT-IGRT) system by analysing (1) the agreement between thermo-optical and stereoscopic X-ray positioning, and (2) the impact of intra-fractional workflows on treatment accuracy and time. Materials and m
Background: Stereotactic body radiotherapy (SBRT) is an established treatment for previously unirradiated spinal metastases; however, the literature is limited with respect to SBRT as a re-irradiation salvage therapy. We performed a systematic review and meta-analysis as basis for joint ESTRO-ISRS clinical practice recommendations of salvage SBRT for spinal metastases. Methods: A systematic review
Supercrystals of lead-halide perovskite nanocrystals combine the semiconducting properties of bulk perovskites with quantum confinement effects and extend them to the macroscopic scale. Supercrystals assembled via a two-layer phase diffusion process using an acetonitrile antisolvent were recently shown to be unusually robust. We investigate how the acetonitrile-assisted self-assembly process influ
Microplastics and nanoplastics (MNPs) are ubiquitous environmental pollutants with increasing implications for human health. While their presence in human tissues is established, the molecular mechanisms driving their potential neurotoxicity remain unclear. This study investigates the impact of polystyrene (PS) on amyloid protein misfolding and cellular metabolism using Optical Photothermal Infrar
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individual
Charged Higgs bosons produced either in top-quark decays or in association with a top quark, subsequently decaying via (Formula presented), are searched for in (Formula presented) of proton-proton collision data at (Formula presented) recorded with the ATLAS detector. Depending on whether the top quark is produced together with the (Formula presented) decays hadronically or semileptonically, the s
Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg
Top-quark pair production is observed in lead-lead ((Formula presented)) collisions at (Formula presented) at the Large Hadron Collider with the ATLAS detector. The data sample was recorded in 2015 and 2018, amounting to an integrated luminosity of (Formula presented). Events with exactly one electron and one muon and at least two jets are selected. Top-quark pair production is measured with an ob
