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This thesis investigates ‘the doing’ of the Swedish social insurance program Activity Compensation (AC). AC is an example of disability policies in Western welfare states. These policies have two goals: to ensure financial security and to promote social participation. In 2003 AC replaced Early Retirement Pension for persons aged 19 to 29 years and who, for medical reasons, have reduced work capaci
Background: Around the globe the electricity sector is strikingly similar, as regardless of nation it is structured around centralized large-scale power production. However, these centralized systems are currently experiencing operational problems related to climate change, energy security and aging grid infrastructures. In Sweden, the lack of investment and maintenance of the grid have created bo
In the context of the COVID-19 pandemic, governments worldwide face the challenge of designing tailored measures of epidemic control to provide reliable health protection while allowing societal and economic activity. In this paper, we propose an extension of the epidemiological SEIR model to enable a detailed analysis of commonly discussed tailored measures of epidemic control—among them group-sp
Control of contemporary, multi-joint prosthetic hands is commonly realized by using electromyographic signals from the muscles remaining after amputation at the forearm level. Although this principle is trying to imitate the natural control structure where muscles control the joints of the hand, in practice, myoelectric control provides only basic hand functions to an amputee using a dexterous pro
Background: The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranul
Andelen unga som beviljas förtidspension under lång tid har ökat, särskilt de med en psykisk diagnos eller unga med lindrig psykisk ohälsa. Denna form av utanförskap innebär att betydande andelar av en generation av unga människor har liten eller ingen koppling till arbetsmarknaden under en större del av sitt vuxna liv.Bara i Sverige har antalet förtidspensionerade mellan 19-29 år fördubblats unde
An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model—Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)—which uses a genetic construct to increase DA synthesi
Presentation of the Filmform Foundation and its archive of experimental film and video, at the website filmarkivet.se, directed by Swedish Film Institute.
Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated with progress
Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of importance to understand the biology of drug targets, particularly the newly emerging ones. A comprehensive evaluation of these targets will benefit drug development with increased likelihood for success in clini
Noise pollution is a growing global public health concern. Among other issues, it has been linked with sleep disturbance, hearing functionality, increased blood pressure and heart disease. Individuals are increasingly using social media to express complaints and concerns about problematic noise sources. This behavior-using social media to post noise-related concerns-might help us better identify t
Quenching of vibrational excitations in resonant inelastic X-ray scattering (RIXS) spectra of liquid acetic acid is observed. At the oxygen core resonance associated with localized excitations at the O–H bond, the spectra lack the typical progression of vibrational excitations observed in RIXS spectra of comparable systems. We interpret this phenomenon as due to strong rehybridization of the unocc
Irrigation is the largest sector of human water use and an important option for increasing crop production and reducing drought impacts. However, the potential for irrigation to contribute to global crop yields remains uncertain. Here, we quantify this contribution for wheat and maize at global scale by developing a Bayesian framework integrating empirical estimates and gridded global crop models
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-
Background: Occupational therapists are generally positive towards use of measuring tools. However, such use may be problematic.Purpose: To illuminate hidden and adverse effects of using measuring tools in occupational therapy.Method: A Foucauldian inspired thematic analysis of the use of measuring tools in 13 reports of practice development projects in Denmark.Findings: Three themes were construcBackground.Occupational therapists are generally positive towards use of measuring tools. However, such use may be problematic.Purpose.To illuminate hidden and adverse effects of using measuring tools in occupational therapy.Method.A Foucauldian inspired thematic analysis of the use of measuring tools in 13 reports of practice development projects in Denmark.Findings.Three themes were constructed:
Organic carbon burial in lake sediments plays an important role in the global carbon cycle, and is heavily affected by the terrestrial organic matter input. However, few studies have focused on long-term changes in terrestrial organic matter input to lakes in response to land-use changes. The aim of this study was to assess variations in sedimentary terrestrial organic matter over the last 1000 ye
To expand our understanding of what tasks are particularly helped by UV vision and may justify the costs of focusing high-energy light onto the retina, we used an avian-vision multispectral camera to image diverse vegetated habitats in search of UV contrasts that differ markedly from visible-light contrasts. One UV contrast that stood out as very different from visible-light contrasts was that of
