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Autoantibodies to the C3 convertase of the alternative pathway of complement, called C3 nephritic factors (C3NeF), cause persistently low C3 in the circulation and production of C3 degradation fragments due to prolonged stabilization of the C3 convertase. C3NeF are associated with glomerulopathy, acquired partial lipodystrophy, and less frequently with increased susceptibility to meningococcal inf
This paper aims to provide conceptual insight on ‘Circular business model experimentation’ by exploring the concept and potential approaches to pursue. The Circular Economy can be a successful driver for change by focusing efforts on economic and environmental issues while also addressing socio-economic challenges such as (un)employment. The business model of firms is viewed as a systematic driver
Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of
We consider the stationary flow of an inviscid and incompressible fluid of constant density in the region D = (0, L) × ℝ2. We are concerned with flows that are periodic in the second and third variables and that have prescribed flux through each point of the boundary ∂D. The Bernoulli equation states that the "Bernoulli function" H := 1/2 |v|2 + p (where v is the velocity field and p the pressure)
The Circular Economy is viewed as an important driver for resolving resource issues and tackling sustainability issues more broadly. The fashion industry operates in a largely linear way and suffers from various environmental, societal and economic challenges. In a Circular Economy, first and foremost, products need to be retained at the highest level, thus slowing resource loops. Slowing resource
The advantages put forward for so-called Smart working may sound very appealing. However, it is unlikely that all stakeholder groups involved will benefit to the same extent, if at all. Many initiatives that seem to be aimed at development of Smart work systems can be seen to be flawed, since they are suggested to support empowerment but are expressed in terms of pre-defined ‘best practice’. This
Detta kapitel analyserar vad man kan kalla automatiserad policyimplementering på digitala plattformar och därmed kombinationen av normativitet och plattformisering. I kapitlet fokuseras betydelsen av de automatiserade verktyg där varianter av artificiell intelligens och maskininlärning används för att moderera och effektivisera olika informationsflöden. Här tecknas tre kategorier där plattformar a
Denna rapport ger en översikt av linjär optimal stokastisk kontroll. De fundamentala problemen formuleras och de centrala resultaten gives, utan bevis men med utförliga fysikaliska tolkningar. Användandet av siffermaskiner både för syntes och implementering behandlas. Vidare diskuteras några praktiska problem förenade med det optimala systemets realisering: val av samplingstid, reelltidsberäkning
The effective use of modern control theory requires suitable mathematical models of the objects to be controlled and of the disturbances. Paper machines have been controlled digitally for a long time. Digital control of basis weight and moisture content is in fact one of the few examples where a digital computer and sensors form a standard package. In spite of this there are still significant gaps
This paper presents analysis of a scheme for iterated identification and control design. The approach is based on least squares identification in closed loop and pole placement design. It has previously been shown that the criteria for control and identification are the same provided that the data filters are chosen properly. The iterated scheme may be viewed as a recursion in model parameters. Ea
Mitochondrial dysfunction is thought to be a hallmark of traumatic brain injury (TBI) and plays a pivotal role in the resulting cellular injury. Cyclophilin D-mediated activation of the mitochondrial permeability transition pore has been suggested to contribute to this secondary injury cascade. Cyclosporine possesses neuroprotective properties that have been attributed to the desensitization of mi
Recent genetic studies have identified alleles associated with opposite effects on adiposity and risk of type 2 diabetes. We aimed to identify more of these variants and test the hypothesis that such favorable adiposity alleles are associated with higher subcutaneous fat and lower ectopic fat. We combined MRI data with genome-wide association studies of body fat percentage (%) and metabolic traits
OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset
Progression to clinical type 1 diabetes varies among children who develop b-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar profiles associated with various types of progression among 600 children from The
Accurate determination of the genetic diversity present in the HIV quasispecies is critical for the development of a preventative vaccine: in particular, little is known about viral genetic diversity for the second type of HIV, HIV-2. A better understanding of HIV-2 biology is relevant to the HIV vaccine field because a substantial proportion of infected people experience long-term viral control,
BACKGROUND: About 13-26% of all acute ischaemic strokes are related to non-valvular atrial fibrillation, the most common cardiac arrhythmia globally. Deciding when to initiate oral anticoagulation in patients with non-valvular atrial fibrillation is a longstanding, common, and unresolved clinical challenge. Although the risk of early recurrent ischaemic stroke is high in this population, early ora
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program
