Device-aided therapies, including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, are available in many countries for the management of the advanced stage of Parkinson’s disease (PD). Currently, selection of device-aided therapies is mainly focused on patients’ motor profile while non-motor symptoms play a role limited to being regarded as

Background: E surgical, anaesthesia, and obstetric (SAO) care were proposed in 2015 by the Lancet Commission on Global Surgery. These aimed to capture access to surgery, surgical workforce, surgical volume, perioperative mortality rate, and catastrophic and impoverishing financial consequences of surgery. Despite being rapidly taken up by practitioners, data points from which to derive the indicat

Solar ultraviolet radiation (UVR) is an important environmental threat for organisms in aquatic systems, but its temporally variable nature makes the understanding of its effects ambiguous. The aim of our study was to assess potential fitness costs associated with fluctuating UVR in the aquatic zooplankter Daphnia magna. We investigated individual survival, reproduction and behaviour when exposed

Cisplatin is one of the most commonly used drugs for the treatment of various solid cancers. However, its efficacy is restricted by severe side effects, especially dose-limiting nephrotoxicity. New platinum-based compounds are designed to overcome this limitation. Previous investigations showed that the platinum(IV)–nitroxyl complex PN149 is highly cytotoxic in various tumor cell lines. In the pre

Ecosystems provide multiple services to humans. However, agricultural systems are usually evaluated on their productivity and economic performance, and a systematic and quantitative assessment of the multifunctionality of agroecosystems including environmental services is missing. Using a long-term farming system experiment, we evaluated and compared the agronomic, economic, and ecological perform

In addition to a majority of insulin-producing β-cells, the mammalian pancreatic islets contain considerable numbers of α1- and α2-cells. While the α2-cells are the cellular source of glucagon, the secretory product stored in the granules of the α1-cells still remains to be identified.Several authors have reported that glucagon stimulates insulin release. This effect of glucagon was found to be de

A seemingly never-ending stream of observers claims that the populist emphasis on nationalism, identity, and popular sovereignty undermines international collaboration and contributes to the crisis of the Liberal International Order (LIO). Why, then, do populist governments continue to engage in regional and international institutions? This Element unpacks the counter-intuitive inclination towards

Debate and literature on the link between degrading environments and human mobility has been increasing exponentially. There is little concrete evidence, however, of efforts or policies that support the management of environmentally influenced mobility. Through discourse analysis using Q-methodology, this research aimed to scrutinize the standoff between opposing views under a fresh lens. One-hund