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ABC om förmaksflimmer på akuten

Förmaksflimmer drabbar mer än 3 procent av Sveriges vuxna befolkning. Detta gör förmaksflimmer till ett vanligt tillstånd på akutmottagningen, dit patienterna kommer med olika symtom som andfåddhet, hjärtklappning, trötthet, bröstsmärta eller oroskänsla. Vid tromboembolisering till hjärnan kan patienten drabbas av stroke, synkope eller sänkt medvetandegrad. Det är därför viktigt att uppmärksamma oAtrial fibrillation (AF) is the most common tachyarrhythmia. When handling patients with AF at the emergency care department it is of utmost importance to take a structural approach, make the right diagnosis, take care of the risk and/or trigger factors, treat and make sure there is an adequate follow-up.

Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: A meta-analysis of randomized clinical trials

BACKGROUND:Although oxygen therapy has been used for over a century in the management of patients with suspected acute myocardial infarction (AMI), recent studies have raised concerns around the efficacy and safety of supplemental oxygen in normoxaemic patients.OBJECTIVE:To synthesise the evidence from randomised controlled trials (RCTs) that investigated the effects of supplemental oxygen therapy

Diagnostic Accuracy of the Electrocardiographic Decision Support – Myocardial Ischaemia (EDS-MI) Algorithm in Detection of Acute Coronary Occlusion

Electrocardiographic Decision Support - Myocardial Ischaemia (EDS-MI) is a graphical decision support for detection and localization of acute transmural ischaemia. A recent study indicated that EDS-MI performs well for detection of acute transmural ischaemia. However, its performance has not been tested in patients with non-ischaemic ST-deviation. We aimed to optimize the diagnostic accuracy of ED

Multicomponent inverse modeling of supercritical fluid extraction of carotenoids, chlorophyll A, ergosterol and lipids from microalgae

The fundamentals of analyte extractable fraction, solubility, partitioning and mass transfer resistance in supercritical fluid extraction were studied using inverse modeling. These phenomena are essential for understanding, predicting and optimizing the supercritical fluid extraction process. Carotenoids, chlorophyll A, ergosterol and total lipids were extracted from the microalgae Chlorella sp. T

A three dimensional multiphysics model of a solid oxide electrochemical cell : A tool for understanding degradation

Mitigating degradation is essential for extending the lifetime of solid oxide electrochemical cells (SOCs). The conditions leading to degradation, e.g. overpotentials, gas partial pressures, thermal gradients are hard, if not impossible, to retrieve experimentally. Thus, to deconvolute the response from cell testing, modeling can be applied to understand the degradation phenomena in greater detail

Tuft cells : Distribution and connections with nerves and endocrine cells in mouse intestine

Tuft cells are gastrointestinal (GI) sensory cells recognized by their characteristic shape and their microvilli “tuft”. Aims of the present study were to elucidate their regional distribution and spatial connections with satiety associated endocrine cells and nerve fibers throughout the intestinal tract. C57BL/6 J mice were used in the experiments. The small intestine was divided into five segmen

The extended law of corresponding states when attractions meet repulsions

Short-range attractive colloids show well-defined phase behaviour in the absence of repulsions, and highly intriguing equilibrium gelation in the presence of long-range repulsions. We present the state diagram of short-range attractive colloids with repulsions that range from fully screened to intermediately ranged, i.e. longer-ranged than the attractions, but shorter ranged than the colloid size.

Genetic variation of acquired structural chromosomal aberrations

Human malignancies are often hallmarked with genomic instability, which itself is also considered a causative event in malignant transformation. Genomic instability may manifest itself as genetic changes in the nucleotide sequence of DNA, or as structural or numerical changes of chromosomes. Unrepaired or insufficiently repaired DNA double-strand breaks, as well as telomere shortening, are importa

Modeling linguistic evolution : A look under the hood

This paper takes a detailed look at some popular models of evolution used in contemporary diachronic linguistic research, focusing on the continuous-time Markov model, a particularly popular choice. I provide an exposition of the math underlying the CTM model, seldom discussed in linguistic papers. I show that in some work, a lack of explicit reference to the underlying computation creates some di

Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS

Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a proteomic workflow combining N-glycosite enrichment and SWATH mass spectrometry, we generate a data resource of 284 blood samples

Acoustic manipulation of cells and microbeads in droplet microfluidics

Droplet microfluidics has emerged as a promising platform for miniaturisation of biological assays on-chip. In droplet microfluidics small water droplets (nL-pL) surrounded by an immiscible carrier oil are generated at high throughput. In these droplets particles such as cells or microbeads can be encapsulated, and the idea is that each of these droplets can be used as small reaction chambers for

Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β -Cells Treated with Palmitate and Oleate

High circulating nonesterified fatty acids (NEFAs) concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS) through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression