Chronic respiratory diseases are often characterized by impaired epithelial function and remodeling. Mast cells (MCs) are known to home into the epithelium in respiratory diseases, but the MC-epithelial interactions remain less understood. Therefore, this study aimed to investigate the effect of MC proteases on bronchial epithelial morphology and function. Bronchial epithelial cells were stimulate

Recent research has foregrounded the importance of student engagement with feedback on writing (Quinton & Smallbone, 2010; Zhang & Hyland, 2018; Handley, Price, & Millar, 2011). At the same time, there is a small but growing body of scholarship exploring the role that feedback plays in developing discipline-specific competencies in student writers in an L2 context (Hyland, 2013). The p

In this paper we investigate the specific mechanisms of British financial influence in the Cape Colony during the diamond mining boom of the late nineteenth century. We do so by offering a detailed exposition of the uneasy marriage between the colonial state and private business sector in the context of the economics and dynamics of extractivism in the periphery. This allows us to encapsulate the

This work aims to unravel the impact of disubstitution patterns on the physical properties and processing characteristics of indole-based aromatic polyesters. A series of hydroxyl-carboxylate (AB-type) monomers with 1,5-disubstituted indole and 3-6 methylene units was conveniently synthesized and used in bulk polycondensation to yield the corresponding polyesters with decent molecular weight. Thes

BACKGROUND: This aggregated population study investigated the impact of the seemingly quasi-randomly assigned school winter holiday in weeks 6-10 (February to early March) on excess mortality in 219 European regions (11 countries) during the COVID-19 pandemic in the spring 2020. A secondary aim was to evaluate the impact of government responses to the early inflow of infected cases. METHODS: Data

CONTEXT/OBJECTIVE: The aim of this study was to examine the effect of statins and other lipid-lowering agents on the development of Graves orbitopathy (GO) in patients with newly diagnosed Graves disease (GD). METHODS: Our sample included the full adult population of individuals living in Sweden with newly diagnosed GD between 2005 and 2018 (n = 34 894). We compared the GO incidence in statin user

The elliptic flow of electrons from beauty hadron decays at midrapidity (|y|

A pre-requisite for the design of wireless systems is the understanding of the propagation channel. While a wealth of propagation knowledge exists for bands below 6 GHz, the same can not be said for bands approaching millimeter-wave frequencies. In this paper, we present the design, implementation and measurement-based verification of a re-configurable 27.5-29.5 GHz channel sounder for measuring d

Vegetation phenology obtained from time series of remote sensing data is relevant for a range of ecological applications. The freely available Sentinel-2 imagery at a 10 m spatial resolution with a ~ 5-day repeat cycle provides an opportunity to map vegetation phenology at an unprecedented fine spatial scale. To facilitate the production of a Europe-wide Copernicus Land Monitoring Sentinel-2 based

Young adults experiencing mental health problems are less educated than their peers, putting them in a more vulnerable position for employment and career possibilities. While Supported employment models have been widely implemented, educational supports may be necessary in order to contribute to longer term and sustainable employment. The aim of this study was to describe the state of current rese

Introduction: The role of chemotherapy for patients with dedifferentiated chondrosarcoma (DDCS) is still under discussion. Here, we present the outcome in patients with DDCS treated with intensive chemotherapy from the EUROpean Bone Over 40 Sarcoma Study. Materials and methods: The chemotherapy regimen included doxorubicin, ifosfamide and cisplatin. Postoperative methotrexate was added in case of

This paper looks into the system of student informants (xuesheng xinxiyuan), which is, to systematically recruit and more generally, to mobilise or encourage the students to watch and inform on their professors on university campuses in China. After Xi Jinping assumed power in late 2012, along with the Chinese Communist Party’s intensifying control of university space, mounting reports show that p

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD

Along with China’s long-delayed response to the COVID-19 outbreak is its nationwide activation of the ‘gridded management’ system. Relying largely on the mass recruitment of the war-time rhetoric and ideology in mobilizing the people to watch and tell on each other, this ‘gridded management’ system is officially highlighted as playing a key role in China’s combat against COVID-19. Through examinin

The cutback was widely used in advanced gas turbines to protect the trailing edge. The land was a main structure in the cutback region. Therefore, the present study describes a numerical investigation on the film cooling performance in the cutback region with various land shapes (straight- expanding land, arch- expanding land, contracting- expanding land and campaniform land) and blowing ratios (0

Herwig 7 is a general-purpose Monte Carlo generator of particle collisions comprising both hard perturbative as well as soft phenomenological physics. Herwig is therefore capable to describe the entire final state of hadronized particles in a collision event. A spacetime topology of a parton system entering hadronization is fully described and tested for the first time. A combination of informatio

The correlation function measured in ultrarelativistic nuclear collisions is strongly non-Gaussian. Using two different models we study which effects can influence its shape and how much. In particular, we focus on the parametrizations expressed with the help of Lévy-stable distributions. We show that the Lévy index may deviate substantially from 2 due to non-critical effects such as resonance dec

The Learning with Errors (LWE) problem receives much attention in cryptography, mainly due to its fundamental significance in post-quantum cryptography. Among its solving algorithms, the Blum-Kalai-Wasserman (BKW) algorithm, originally proposed for solving the Learning Parity with Noise (LPN) problem, performs well, especially for certain parameter settings with cryptographic importance. The BKW a