The complement system is a well-characterized cascade of extracellular serum proteins that is activated by pathogens and unwanted waste material. Products of activated complement signal to the host cells via cell surface receptors, eliciting responses such as removal of the stimulus by phagocytosis. The complement system therefore functions as a warning system, resulting in removal of unwanted mat

Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP). In the present study, we studied the role of extracellular cold-inducible RNA-binding protein (eCIRP), a novel damage-associated-molecular-pattern molecule, in severe AP. C57BL/6 mice underwent retrograde infusion of taurocholate into the pancreatic duct. C23, an eCIRP inhibitor, was given 1 h prio

Apolipoprotein M (apoM) was first identified and characterized to the apolipoprotein family in 1999. Human apoM gene is located in a highly conserved segment in the major histocompatibility complex (MHC) class III locus on chromosome 6 and codes for an about 23 kDa protein that structurally belongs to the lipocalin superfamily. ApoM is selectively expressed in hepatocytes and in the tubular epithe

Background: While discontinuation of COPD maintenance medication is a known problem, the proportion of patients with discontinuation and its geographical and sociodemographic distribution are so far unknown in Sweden. Therefore, we analyse this question by applying an innovative approach called multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Patients and Metho

In modern history, states have typically attempted to eliminate nomadism. Perhaps uniquely, Sweden reinforced nomadism among some of its Sámi population. In this chapter, I argue that the reason for this was twofold. First, reindeer herding necessitated nomadism, and it was thought to be the only economic contribution parts of the traditional Sámi land could provide. Second, a discourse of Boreali

The End of History was the title of Francis Fukuyama’s book (Fukuyama 1992), suggesting that with the demise of communism in the Soviet Union and Eastern Europe after the Berlin Wall, the consequence was that The Market had come out victorious after the Cold War, and now there was only one way ahead, and the savior capitalism would relentlessly lead to democracy. Now we know that this is not the c

Sweden attracted much attention as an interesting socioeconomic role model already in the 1930s, especially after Marquis Childs published his famous and influential book, The Swedish Middle Way (1936). Childs’ main argument was that the “Swedish model” was a successful “socialist” policy with a growing cooperative sector-as a counterbalance to the private sector-and effective crisis management. O

In this volume, the authors reflect on the question “what is socialism” as it pertains to today’s economy. There is particular emphasis on democratic socialism models as a potential alternative to classic authoritarian socialism. A number of topical questions are addressed such as: What is democratic socialism and is it feasible, or even viable? What can be learnt from existing democratic socialis

Introduction Children with appendicitis often present with complicated disease. The aim of this study was to describe the clinical management of pediatric appendicitis, and to report how disease severity and operative modality are associated with short- and long-term risks of adverse outcome. Materials and Methods A nationwide retrospective cohort study of all Swedish children (

Persons who have survived a stroke might lower the risk of having recurrent strokes by adopting a healthier lifestyle with more exercise. One way to promote exercising is by fitness or exergame apps for mobile phones. Health and fitness apps are used by a significant portion of the consumers, but these apps are not targeted to stroke survivors, who may experience cognitive limitations (like fatigu

High purity and sequence homogeneity of intrinsically disordered proteins are prerequisites for reproducible studies of the kinetics and equilibrium of their self-assembly reactions. Starting from the pure state enables quantitative studies of intrinsic and extrinsic factors in the process to understand its molecular determinants. Here we outline detailed protocols for recombinant expression and p

Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T-cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be consider

We shall study the solvability of pseudodifferential operators which are not of principal type. The operator will have complex principal symbol satisfying condition (Ψ) and we shall consider the limits of semibicharacteristics at the set where the principal symbol vanishes of at least second order. The convergence shall be as smooth curves, and we shall assume that the normalized complex Hamilton

Importance: Neuroprognostication studies are potentially susceptible to a self-fulfilling prophecy as investigated prognostic parameters may affect withdrawal of life-sustaining therapy. Objective: To compare the results of prognostic parameters after cardiac arrest (CA) with the histopathologically determined severity of hypoxic-ischemic encephalopathy (HIE) obtained from autopsy results. Design,

Introduction:The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variations in breath-hold.Materials and methods: Single field PBS plans at five degrees increments in the transve

Background: The purpose of this study was to examine visual outcome, endocrine function and tumor control in a prospective cohort of craniopharyngioma patients, treated with fractionated stereotactic radiation therapy (FSRT). Material and methods: Sixteen adult patients with craniopharyngiomas were eligible for analysis. They were treated with linear accelerator-based FSRT during 1999–2015. In all

Background and purpose To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. Materials and methods The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered

Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. P

Background and purpose Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early 18F-fluoroethyl-tyrosine (18F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). Material and methods A phase I clinical trial of re-irradiation of HGG was carried o