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Detecting the entire repertoire of tumor-specific reactive tumor-infiltrating lymphocytes (TILs) is essential for investigating their immunological functions in the tumor microenvironment. Current in vitro assays identifying tumor-specific functional activation measure the upregulation of surface molecules, de novo production of antitumor cytokines, or mobilization of cytotoxic granules following

The thesis studies the use of cloud native software and platforms to implement critical closed loop control. It considers technologies that provide low latency and reliable wireless communication, in terms of edge clouds and massive MIMO, but also approaches industrial IoT and the services of a distributed cloud, as an extension of commercial-of-the-shelf software and systems.First, the thesis defThe thesis studies the use of cloud native software and platforms to implement critical closed loop control. It considers technologies that provide low latency and reliable wireless communication, in terms of edge clouds and massive MIMO, but also approaches industrial IoT and the services of a distributed cloud, as an extension of commercial-of-the-shelf software and systems.First, the thesis def

Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. Among them, the Aβ40 variant is predominantly found in the cerebrospinal fluid while the Aβ42 variant appears as fibrillar aggregates in the brain of AD patients. In vitro studies confi

THRUSH begins with my reinterpretation of the same audio that Messiaen used for his transcriptions of the North American Songbirds, blackbird and wood thrush. These audio samples were digitized and analysed using PRAAT and C-Speech, from which I made new transcriptions that were more accurate representations of the physical acoustical signal. Of course, a temporal framework had to be established f

Spatially-coupled serially concatenated codes (SC-SCCS) are a class of turbo-like codes constructed by interconnecting a sequence of SCCS using a set of block permutors. At short block lengths, however, the bit-error-rate (BER) performance of SC-SCCS constructed by independent block permutors exhibits a high error floor. In this paper, we propose an alternative method for constructing SC-SCCS to m

Excited states in 56Zn were populated following one-neutron removal from a 57Zn beam impinging on a Be target at intermediate energies in an experiment conducted at the Radioactive Isotope Beam Factory at RIKEN. Three γ rays were observed and tentatively assigned to the 6+ → 4+ → 2+ → 0+ yrast sequence. This turns 56Zn into the heaviest Tz=−2 nucleus in which excited states are known. The excitati

We examine socioecological drivers of nutrient overloading and eutrophication in the Chesapeake Bay associated with poultry production on the Delmarva Peninsula. We use a social metabolic analysis—rooted in a political-economy perspective—that highlights the interchange of matter and energy and the inextricable links within and between social and ecological systems, illuminating the social structu

Sustainability transformations call forth new forms and systems of knowledge across society. However, few tools and processes exist for promoting dialogue among different interests and normative stances in knowledge co-creation. In this article, we build on the notion of thought collectives to argue that understanding and moderating normative tensions are necessary if sustainability science is to

BACKGROUND: The glabellar flap is a common technique for surgical repair after tumor excision in the medial canthal area. However, the outcome may be affected by partial flap necrosis. Little is known about the impact of surgery on blood perfusion and the postoperative course of reperfusion due to the absence of reliable and noninvasive perfusion monitoring techniques. The aim of this study was to

Introduction: Regular physical activity is associated with longevity in adults receiving hemodialysis, but it is uncertain whether this association varies by causal pathways (cardiovascular and noncardiovascular). Methods: DIET-HD was a prospective, multinational study of adults undergoing hemodialysis across Europe and Argentina. We classified participants as physically inactive, occasionally act

Context and purpose: There is an urgent need to develop vitamin D dietary recommendations for dark-skinned populations resident at high latitude. Using data from randomised controlled trials (RCTs) with vitamin D3-supplements/fortified foods, we undertook an individual participant data-level meta-regression (IPD) analysis of the response of wintertime serum 25-hydroxyvitamin (25(OH)D) to total vit

Introduction: Ixekizumab, a selective interleukin-17A antagonist, was compared with adalimumab in the SPIRIT-H2H study (NCT03151551) in patients with psoriatic arthritis (PsA) and concomitant psoriasis. This post hoc analysis reports outcomes to week 52 in patients from SPIRIT-H2H, stratified by baseline psoriasis severity. Methods: SPIRIT-H2H was a 52-week, multicenter, randomized, open-label, ra

Introduction: Remaining disability after stroke can reduce a person's life satisfaction. Because previous studies of life satisfaction show inconsistent results, there is a need for more knowledge regarding perceived life satisfaction after stroke and associated factors. Objective: To assess perceived life satisfaction after stroke in relation to Swedish reference values; and the association with