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New Antidiabetic Agents for the Treatment of Heart Failure in Hypertensive Patients

The development of newer glucose-lowering drugs for the treatment of type 2 diabetes in recent years, such as the SGLT-2 inhibitors and GLP-1 receptor agonists/analogues with well-documented clinical benefits from large trials, has influenced international guidelines. These drugs are able to reduce both macro- and microvascular events in patients with type 2 diabetes and to prevent worsening of di

Train stations’ impact on housing prices : Direct and indirect effects

Investments in rail are usually expected to improve accessibility for individuals. The value of the additional accessibility is often measured by the impact on housing prices nearby. This paper analyses the City Tunnel in Southern Sweden, a major railway investment that resulted in two new train stations in 2010: the Triangeln and Hyllie train stations. A station may affect housing prices both dir

Integrating shared e-scooters as the feeder to public transit : A comparative analysis of 124 European cities

E-scooter sharing is a potential feeder to complement public transit for alleviating the first-and-last-mile problem. This study investigates the integration between shared e-scooters and public transit by conducting a comparative analysis in 124 European cities based on vehicle availability data. Results suggest that the integration ratios of e-scooter sharing in different cities show significant

Polydopamine functionalized dendritic fibrous silica nanoparticles as a generic platform for nucleic acid-based biosensing

Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid biomarkers. Our approach involves the utilization of 6-carboxyfluorescein modified singl

Detection of Pseudomonas aeruginosa infection using a sustainable and selective polydopamine-based molecularly imprinted electrochemical sensor

Pyocyanin, a redox-active secondary metabolite produced by Pseudomonas aeruginosa, serves as a crucial virulence factor. Detection and quantification of pyocyanin can aid early diagnosis of infection. A selective and sensitive molecularly imprinted electrochemical sensor was constructed by using a green polymerization technique to deposit an ultrathin polydopamine film on an electrode modified wit