The gene encoding calpain-10 (CAPN10) has been identified as a candidate gene for type 2 diabetes. Our aim was to study the impact of genetic (heritability and polymorphisms) and nongenetic (insulin, free fatty acids, and age) factors on CAPN10 mRNA expression in skeletal muscle using two different study designs. Muscle biopsies were obtained before and after hyperinsulinemic-euglycemic clamps fro

Polymorphonuclear leukocyte infiltration into tissues in host defense and inflammatory diseasecauses increased vascular permeability and edema formation through unknown mechanisms.Here, we report the involvement of a paracrine mechanism in neutrophil-evoked alteration inendothelial barrier function. We show that upon neutrophil adhesion to the endothelial lining,leukocytic 2 integrin signaling tri

Hur mycket kostar det i Sverige att “sätta en jude på plats“? Enligt dagens rättspraxis ett tusen kronor i skadestånd, för psykiskt lidande, samt 50 till 80 dagsböter. Detta pris är, enligt Skövde tingsrätt, ett kraftigt straff. Den 28 augusti 1991 åtalades två unga män, E och F, vid Skövde tingsrätt för “ofredande“ av S, en värnpliktskamrat av judisk härkomst. De två unga männen hade “smädat“ S g

Popular Abstract in Swedish Korrosion av stålarmering i betong orsakade höga reparationskostnader för Ölandsbron, och är en grundläggande fråga vid val av material och utförande för Öresundsbron. Avhandlingen behandlar hur val av betongkvalité och tjocklek hos betongen som skyddar armeringen påverkar dels hur fort saltvatten tränger in i betong för att till slut nå armeringen, dels hur mycket Factors affecting the total chloride threshold for initiation of pitting corrosion in reinforced concrete were investigated by means of field and laboratory exposure tests. Factors affecting the chloride penetration into concrete were also investigated by means of field tests. The thesis consists of a summary (86 p.) and 11 papers attached. Measured total chloride thresholds for uncracked concret

A compartmental model describing the distribution and retention of radioactive iodide in thyroid and other organs is presented. The model is developed from published ICRP models. It is designed primarily for radiation dosimetry of iodine radionuclides used in nuclear medicine, but may also be useful for occupational radiation protection. In the proposed model, the distribution of iodide to the thy

The main theme of this thesis is the connection between weighted biharmonic Green functions and weighted Bergman kernels. In the first paper, which is a joint work with H. Hedenmalm and S. Shimorin, we prove that weighted biharmonic Green functions are positive for weights which satisfy a mean-value condition and whose logarithms are subharmonic. To achieve this, we use a variational formula due t

We combine ultrasonic trapping and capillary electrophoresis (CE) with the goal to detect ultra-low concentrations of proteins via size-selective separation and enrichment of antibody-coated latex spheres. An 8.5 MHz standing ultrasonic wave is longitudinally coupled into the sub-100-small mu, Greekm diam capillary of the CE system. Competition between acoustic and viscous forces result in in-flow

Childhood sexuality and children's sexual experiences have become increasingly important to study because our knowledge on the impact of sexually abusive experiences on children's developing sexuality has increased. The main aim of this paper was to study aspects of young adults' recollections of their sexual experiences before the age of 13, solitary and shared, mutual as well as coercive. Anonym

Aim of the study. To investigate intrauterine infection as a cause for unexplained stillbirth. Methods. Chorioamnionitis was studied in a material of stillbirths (117 subjects from the years 1985-1994) from a region in the south Sweden. Control material (126 alive and healthy newborns and with healthy mothers) was gathered from the same region. Results. Chorioamnionitis was a common diagnosis bo

Popular Abstract in Swedish Jordens havsnivå förändras kontinuerligt. I ett längre geologiskt tidsperspektiv styrs förändringarna av processer i jordens inre, men i ett kortare tidsperspektiv spelar yttre processer, såsom tillväxt och avsmältning av inlandsisar, stor roll för havets nivåförändringar. Det grönländska istäcket är idag norra halvklotets enda inlandsis och dess tillväxt och avsmältninNew results are presented from the investigation of relative sea-level changes in the Nanortalik and Qaqortoq-Narsarsuaq areas in SW Greenland from c. 11 000 cal. years BP to the present. Isolation and transgression sequences from seven lakes and seven tidal basins are identified using some of the traditional methods such as stratigraphic description, magnetic susceptibility, saturated induced rem

Abstract in Spanish El objeto de este estudio es el Programa Social Agropecuario (PSA) y su interacción con diferentes actores locales en la conformación de las ferias francas en la provincia de Misiones. Estos espacios de comercialización de la pequeña producción agropecuaria comenzaron a organizarse a partir de 1995 y contaron con la participación no sólo del PSA, sino también del gobierno proviThe object of study of this article is the Agriculture Social Program (PSA) and its interaction with diverse local actors in the constitution of the farmers' markets in the province of Misiones, Northeastern Argentina. These markets are social and political spaces for commercialization of small scale agriculture production. The first one emerged in 1995 thanks to the participation of a network of

The case of a neonate who presented with symptoms of upper limb ischemia related to spontaneous multiple arterial and venous thromboses that were demonstrated by colour Doppler sonography and digital subtracted angiography is reported. The presentation of limb ischaemia at birth may be the warning sign of simultaneous cerebral infarction.

CYP17 encodes cytochrome p450c17 alpha, which mediates activities essential for the production of sex steroids. Common germ line variation in the CYP17 gene has been related to inconsistent results in breast and prostate cancer, with most studies focusing on the nonsynonymous single nucleotide polymorphism (SNP) T27C (rs743572). We comprehensively characterized variation in CYP17 by direct sequenc