Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators have been investigated for their ability to prevent neurodegenerative diseases with features of iron overload. Given the non-trivial side effects of classical iron chelators, lactoferrin (Lf), a multifunctional iron-binding globular glycoprotein, was screened to identify novel neuroprotective pathways again

Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc

This article started out as a keynote lecture at the ‘Coarseness of the Brontës: A Reappraisal’ conference in Durham on 10-11 August 2017. It raises issues in which the ‘coarseness’ of The Tenant of Wildfell Hall (1848) - its most striking characteristic, according to censorious 1848 reviewers - is a central element. These issues include the violent Hattersley marriage, the manifestations of physi

As cell and molecular biology is becoming increasingly quantitative, there is an upsurge of interest in mechanistic modeling at different levels of resolution. Such models mostly concern kinetics and include gene and protein interactions as well as cell population dynamics. The final goal of these models is to provide experimental predictions, which is now taking on. However, even without matured

Aptitude for and proficiency in acquiring new languages varies in the human population but their neural bases are largely unknown. We investigated the influence of cortical thickness on language learning predictors measured by the LLAMA tests and a pitch-change discrimination test. The LLAMA tests are first language-independent assessments of language learning aptitude for vocabulary, phonetic wor

Aim: This study examined medical and psychosocial risk factors in children born to women with addiction problems during pregnancy and the children's needs for extra medical and psychosocial resources. Methods: Swedish midwives routinely screen pregnant women for drugs and alcohol and refer women with addictions to the Maternity and Child Healthcare Resource Team. We investigated the medical record

SeeMe is a pedestrian crosswalk warning system with automatic pedestrian detection that is mounted on crosswalk signs. Amber flashing lights are activated when pedestrians are approaching or crossing the crosswalk. The aim is to attract motorists’ attention, to improve yielding behavior and to reduce conflicts. A before-after study with a matched comparison group has been conducted in the Norwegia

Fishers are often perceived to be poor, and low income levels are used to justify subsidies and other types of direct and indirect income support to maintain coastal communities. In this study fishers’ income levels are investigated in four Nordic countries; Denmark, Iceland, Norway and Sweden for different types of fishers and vessels and in comparison to alternative occupations. The most importa

Autoantibodies to the C3 convertase of the alternative pathway of complement, called C3 nephritic factors (C3NeF), cause persistently low C3 in the circulation and production of C3 degradation fragments due to prolonged stabilization of the C3 convertase. C3NeF are associated with glomerulopathy, acquired partial lipodystrophy, and less frequently with increased susceptibility to meningococcal inf

This paper aims to provide conceptual insight on ‘Circular business model experimentation’ by exploring the concept and potential approaches to pursue. The Circular Economy can be a successful driver for change by focusing efforts on economic and environmental issues while also addressing socio-economic challenges such as (un)employment. The business model of firms is viewed as a systematic driver

Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of

We consider the stationary flow of an inviscid and incompressible fluid of constant density in the region D = (0, L) × ℝ2. We are concerned with flows that are periodic in the second and third variables and that have prescribed flux through each point of the boundary ∂D. The Bernoulli equation states that the "Bernoulli function" H := 1/2 |v|2 + p (where v is the velocity field and p the pressure)

The Circular Economy is viewed as an important driver for resolving resource issues and tackling sustainability issues more broadly. The fashion industry operates in a largely linear way and suffers from various environmental, societal and economic challenges. In a Circular Economy, first and foremost, products need to be retained at the highest level, thus slowing resource loops. Slowing resource

The advantages put forward for so-called Smart working may sound very appealing. However, it is unlikely that all stakeholder groups involved will benefit to the same extent, if at all. Many initiatives that seem to be aimed at development of Smart work systems can be seen to be flawed, since they are suggested to support empowerment but are expressed in terms of pre-defined ‘best practice’. This

Detta kapitel analyserar vad man kan kalla automatiserad policyimplementering på digitala plattformar och därmed kombinationen av normativitet och plattformisering. I kapitlet fokuseras betydelsen av de automatiserade verktyg där varianter av artificiell intelligens och maskininlärning används för att moderera och effektivisera olika informationsflöden. Här tecknas tre kategorier där plattformar a

Denna rapport ger en översikt av linjär optimal stokastisk kontroll. De fundamentala problemen formuleras och de centrala resultaten gives, utan bevis men med utförliga fysikaliska tolkningar. Användandet av siffermaskiner både för syntes och implementering behandlas. Vidare diskuteras några praktiska problem förenade med det optimala systemets realisering: val av samplingstid, reelltidsberäkning

The effective use of modern control theory requires suitable mathematical models of the objects to be controlled and of the disturbances. Paper machines have been controlled digitally for a long time. Digital control of basis weight and moisture content is in fact one of the few examples where a digital computer and sensors form a standard package. In spite of this there are still significant gaps