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Peptihub (https://bioinformaticscollege.ir/peptihub/) is a meticulously curated repository of cancer-related peptides (CRPs) that have been documented in scientific literature. A diverse collection of CRPs is included in the PeptiHub, showcasing a spectrum of effects and activities. While some peptides demonstrated significant anticancer efficacy, others exhibited no discernible impact, and some e

BACKGROUND: Despite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk. METHODS AND RESULTS: Individual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration

Direct thermal-to-electric energy converters typically operate in the linear regime, where the ratio of actual maximum power relative to the ideal maximum power, the so-called fill factor (FF), is 0.25. Here, we show, based on fundamental symmetry considerations, that the leading order nonlinear terms that can increase the FF require devices with broken spatial symmetry. Studying nonlinear, thermo

Hamilton’s rule provides the cornerstone for our understanding of the evolution of all forms of social behavior, from altruism to spite, across all organisms, from viruses to humans. In contrast to the standard prediction from Hamilton’s rule, recent studies have suggested that altruistic helping can be favored even if it does not benefit relatives, as long as it decreases the environmentally indu

Energy conservation measures (ECMs) are often chosen for their immediate benefits, such as suitability to past/current climate conditions and rapid economic returns. However, the longevity of these ECMs poses a risk of becoming outdated or ineffective as climate change alters the very climatic parameters they were designed for. This paper provides insight into the foresight required when selecting

Context. Open clusters are ideal tools for tracing the abundances of different elements because their stars are expected to have the same age, distance, and metallicity. Therefore, they serve as powerful tracers for investigating the cosmic origins of elements. This paper expands on a recent study by us, in which the element fluorine was studied in seven open clusters; here we add six open cluster

Half of parents to infants and toddlers experience unwanted intrusive thoughts (UITs) about intentionally harming their child. For some, this can lead to impaired parental self-efficacy, elevated parental stress, and symptoms of depression. Many do not disclose their thoughts due to shame. Our research group has developed a self-guided online cognitive intervention for parents with distressing UIT

US premiere of the work Three Chapel Miniatures (2024):1. Fable Animals2. Saint Heliga Birgitta -BirGittA BirGErSDottEr -1303, Saint 13903. Dance of DeathPeter Sheppard Skærved, soloviolin

In-store smart technology is rapidly transforming service delivery and value creation in the retail sector. However, despite these advances, academic acumen of customers' perceived value of their smart service interactions remains tenuous, exposing an important omission in extant literature. Addressing this gap, we conceptualize, operationalize, and validate smart service value (SSV) in the retail

We construct tradable risk factors using combinations of large and liquid mutual funds (long leg) and ETFs (exchange-traded funds) (long and short legs), based on their holdings, for both retail and institutional investors. Exploiting a novel dataset, our tradable factors take into account ETF shorting costs. Assessing the performance of our tradable factors against standard “on-paper” factors, weWe construct tradable risk factors using combinations of large and liquid mutual funds (long leg) and ETFs (exchange-traded funds) (long and short legs), based on their holdings, for both retail and institutional investors. Exploiting a novel dataset, our tradable factors take into account ETF shorting costs. Assessing the performance of our tradable factors against standard “on-paper” factors, we

We evaluate pseudo-real-time out-of-sample nowcasts for Swedish GDP employing factor models and mixed-data sampling regressions with single predictor variables. These two model classes can handle the data irregularities of a ragged-edge sample and differing sampling frequencies. The results show that pooling of the nowcasts outperforms a simple benchmark, even though only very few of the underlyinWe evaluate pseudo-real-time out-of-sample nowcasts for Swedish GDP employing factor models and mixed-data sampling regressions with single predictor variables. These two model classes can handle the data irregularities of a ragged-edge sample and differing sampling frequencies. The results show that pooling of the nowcasts outperforms a simple benchmark, even though only very few of the underlyin

Music by Robert Schumann (1838), orchestrated by Rolf Martinsson. Polish premiere. Instrumentation: orchestra

This study aims to investigate and disentangle the impact of land use and climate variability on the Baltic Sea coastal zone from a millennial perspective. To assess the environmental status of the coastal zone we make use of siliceous microfossils (mainly diatoms), stable nitrogen and carbon isotopes, organic carbon accumulation rates, and lithological changes analyzed in a sediment core collecte