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OBJECTIVEParalleling the rise of pediatric obesity, the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) is increasing among youth. In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk o

This thesis presents a new method for design of PI and PID controllers with the level of control signal activity taken into consideration. The main reason why the D-part is often disabled in industrial control loops is because it leads to control signal sensitivity of measurement noise. A frequently varying control signal with too high amplitude will very likely lead to actuator wear and tear. For

Insulin sensitivity declines in overweight and obese individuals and, under normal conditions, insulin secretion adaptively increases which in healthy non-diabetic subjects maintains normal glycemia. This adaptation is best described by the disposition index derived from modeling of insulin and glucose data from an intravenous glucose tolerance testing (IVGTT). One caveat of the IVGTT is that basi

Background Frail elderly people need an integrated and coordinated care. The two-armed study "Continuum of care for frail elderly people" is a multi-professional and multidimensional intervention for frail community-dwelling elderly people. It was designed to evaluate whether the intervention programme for frail elderly people can reduce the number of visits to hospital, increase satisfaction wit

På Kullaberg finns ett drygt 30-tal kustnära grottor. Klippor och branta stup gör dem svåra att nå, från hav och från land. Hur har grottorna använts under de tusentals år som de funnits? Hur har bilden av grottmänniskor vuxit fram och har de överhuvudtaget funnits på Kullaberg? Arkeologiska utgrävningar och osteologiska djurbensanalyser från några av grottorna ger en del av svaren. Lokalhistoria

Computer vision is today a wide research area including topics like robot vision, image analysis, pattern recognition, medical imaging and geometric reconstruction problems. Over the past decades there has been a rapid development in understanding and modeling different computer vision applications. Even though much work has been devoted to modelling different problems, less work has been spent on

Objective - To determine if the dipeptidyl peptidase 4 inhibitor vildagliptin more effectively than the sulfonylurea glimepiride inhibits glucagon levels during meal. Research design and methods - Glucagon responses to a standard meal were measured at baseline and study endpoint (mean 1.8 years) in a trial evaluating add-on therapy to metformin with vildagliptin 50 mg bid compared to glimepiride u

The two major aims of this study are (1) To test the performance of the Landscape Reconstruction Algorithm (LRA) to quantify past landscape changes using historical maps and related written sources, and (2) to use the LRA and map reconstructions for a better understanding of the origin of landscape diversity and the recent loss of species diversity. Southern Sweden, hemiboreal vegetation zone. The

A series of aromatic multiblock copolymers based on alternating segments of hydrophilic sulfonated polysulfone (PSU) and hydrophobic polyfluoroether (PFE) were prepared and characterized as proton exchange membranes. PSU precursor blocks were synthesized by polycondensation of dichlorodiphenylsulfone and resorcinol, and PFE precursor blocks were prepared by combining decafluorobiphenyl and isoprop

Although the phenomenon of resistance to change has gained considerable attention in organization theory over the years, the meaning of the concept is rarely discussed. In this paper, a conceptual framework is suggested that distinguishes between four interpretations of resistance and builds upon the two variables of changeability and emotionality. Each interpretation is based on various assumptio

Background: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling. Methods: To investigate this signalling event, a low sulphated HS (500 mu g/ml) w

Zinc oxide nanorod-extended gate field effect transistor (MOSFET) is demonstrated for the detection of calcium (Ca2+) ions. ZnO nanorods were grown on the surface of a silver wire to produce an electrochemical nanosensor for selectively detecting Ca2+. The electrochemical response from the interaction between the ZnO nanorods and Ca2+ in an aqueous solution is coupled directly to the gate of a fie

This study investigates the effects that public sector reforms had in the cultural field in European countries over the past two decades. The study highlights changing conditions for public/nonprofit management due to governance and public sector reforms. It does so by applying a multidisciplinary literature survey methodology, which is rare in management studies. The literature survey identifies

This paper combines an atmospheric transport model and a terrestrial ecosystem model to estimate gross primary productivity (GPP) and net ecosystem productivity (NEP) of the land biosphere. Using atmospheric CO2 observations in a Carbon Cycle Data Assimilation System (CCDAS) we estimate a terrestrial global GPP of 146 +/- 19 GtC/yr. However, the current observing network cannot distinguish this be

Populärvetenskaplig artikel om kemisten och nobelpristagaren Fritz Haber, som arbetade med att ta fram stridsgas före och under första världskriget.

Brachyradia, new genus, is proposed and described for two new species of the tribe Exechiini (Diptera: Mycetophilidae) from the Oriental and Australasian regions. The type species, Brachyradia asianca, new species, is described from Thailand, Malaysia, and Indonesia (Sulawesi), and a second species, Brachyradia australis, new species, from Indonesia (Sulawesi) and Papua New Guinea. The systematic

The enzyme myeloperoxidase shows several unusual properties compared to other peroxidases, e.g. a red-shifted absorption spectrum and a peroxidase activity towards chloride. It has been suggested that this is caused by the unusual covalent links between the heme group and the surrounding protein, but whether it is caused by the two ester links to Glu-242 and Asp-94 or the sulfonium ion linkage to