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Purpose: Identifying biomarkers of radiotherapy (RT) response is important for optimizing the treatment of early breast cancer. In this study, we tested the interaction between endothelial cell (EC) expression of phospho-Tyr397-FAK (pY397-FAK) and adjuvant-RT on clinical outcomes after breast-conserving surgery (BCS) within a randomized study. Preclinical data suggest an enhanced effect of RT on l

Objectives: To investigate sex differences in patient-reported outcome measures (PROMs) among axSpA patients initiating their first TNFi and identify factors contributing to these disparities over the follow-up. Methods: Data were included from 15 EuroSpA registries and consisted of axSpA patients initiating their first TNFi, with ≥2 measurements for each analysed PROM (BASDAI and BASFI, scale 0–1

Boreal rivers and streams are significant sources of carbon dioxide (CO2) and methane (CH4) for the atmosphere. Yet the controls and the magnitude of these emissions remain highly uncertain, as current estimates are mostly based on indirect and discrete flux measurements. In this study, we present and analyse the longest CO2 and the first ever CH4 flux dataset measured by the eddy covariance (EC)

It is elucidated how crystallization can be used to create lateral surface nanostructures in a size regime toward sub-10 nm using molecular self-assembly of short chain crystallizable block copolymers (BCP) and assist in overcoming the high-χ barrier for microphase separation. In this work, an amphiphilic double-crystalline polyethylene-b-polyethylene oxide (PE-b-PEO) block co-oligomer is used. A

We describe the genetic characteristics of a fusidic acid- and meticillin-resistant Staphylococcus aureus (MRSA) clone widespread in Europe, based on whole genome sequences from 317 isolates. The clone is causing impetigo and other skin and soft tissue infections, primarily in young children. Comparison with publicly available S. aureus ST121 sequences showed that the clone is clearly distinct fro

Background. Achromobacter xylosoxidans and Pseudomonas aeruginosa are two pathogens that cause persistent airway infections in individuals with cystic fibrosis (CF). The persistence of P. aeruginosa is partly due to a high capacity to form biofilms and the ability to exert antagonism against other bacteria. Loss of microbial diversity in conjunction with chronic P. aeruginosa colonization is

Background and aims: Gambling disorder (GD) is a behavioral addiction often co-occurring with various mental health concerns, such as problematic pornography use (PPU). The specific impact of the co-occurrence of GD and PPU on treatment outcome remains underexplored. This study aimed to compare the treatment outcomes of individuals actively receiving treatment for GD (n = 172; 3.49% females), dist

The aim of this study was to explore factors psychotherapists believe influence their choice of theory, method, and techniques when doing therapeutic work. Semi-structured interviews were conducted with six certified psychotherapists and one psychotherapist in training. The interviews were analyzed using Interpretative Phenomenological Analysis (IPA), a qualitative methodology which explores how i

This biographical study explores the composition of civil society elites in the United Kingdom by analyzing 154 biographies of governance and executive leaders from the most resource-rich civil society organizations. Drawing on concepts from elite and nonprofit leadership studies, the research explores internal homogeneity—similarities within the group—and external homogeneity—common traits with oThis biographical study explores the composition of civil society elites in the United Kingdom by analyzing 154 biographies of governance and executive leaders from the most resource-rich civil society organizations. Drawing on concepts from elite and nonprofit leadership studies, the research explores internal homogeneity—similarities within the group—and external homogeneity—common traits with o

At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution proposes that this six to eight residue motif could have sparked the emergence of the very first nucleoside triphosphatases—a striking example of evolutionary continuity from simple beginnings, if true. To test this provocative model, seven disembodied Walker A

Strong correlation remains a significant challenge for DFT with no satisfying solutions found yet within the standard Kohn-Sham framework. Instead, for decades, a number of different approaches have been suggested to combine the accuracy of multiconfigurational methods with the efficiency of DFT. In this article, we demonstrate that many of these methods are or would be significantly improved by b

Losses and damages from climate change are not just a future risk but already a present reality, and “Loss and Damage” (L&D) as a policy domain has been formalised under the United Nations Framework Convention on Climate Change (UNFCCC), alongside mitigation and adaptation. While climate services currently provide strong support for adaptation and disaster recovery, here we propose that an exp

Background. Young adults starting kidney replacement therapy (KRT) during childhood and reaching their 18th birthday (i.e. adult survivors of childhood KRT) form a challenging population of interest to nephrologists treating adults, as during this period there will be a transition to adult renal centres. Nonetheless, few studies have focused on the epidemiology of KRT in this group. We aimed to pr

Background: Monitoring metabolites of tamoxifen, such as endoxifen, has been suggested as a strategy to ascertain therapeutic effect of tamoxifen therapy, but clinical guidelines are missing. Herein, we aim to investigate the outcome of endoxifen concentrations of low-dose tamoxifen, using change in mammographic breast density as a proxy for therapy response. Methods: In the randomized KARISMA-Tam

Aim: The selective use of defunctioning stomas in anterior resection for rectal cancer hinges on accurately predicting anastomotic leakage. The aim of this study was to develop a prediction model for use in a prospective randomized clinical trial. Method: Colorectal Cancer Database (CRCBaSe) Sweden was used to identify patients who underwent low anterior resection for rectal cancer 2007–2021. Elig

This chapter examines the integration of VR in teaching, focusing on teachers' experiences, perceptions, and challenges. Using a mixed-methods approach, qualitative data from 156 teachers were analyzed with NLP and AI-driven models. The findings show that VR enhances student engagement, motivation, and experiential learning by making abstract concepts accessible and providing risk-free environment

Tonåringar utgör en viktig källa till flexibel och lågavlönad arbetskraft inom servicesektorn. Trots detta saknas forskning som belyser och problematiserar deras sysselsättningsmönster, anställningsvillkor och arbetserfarenheter – särskilt i en nordisk kontext. Denna avhandling analyserar gymnasieelever som arbetskraft i Sverige, i skärningspunkten mellan kundnära servicebranscher som är beroende Teenage students constitute an important source of flexible, low-cost labor in interactive service sectors. However, existing empirical research has primarily treated their labor as transitional, focusing on its impact on future employment or labor market outcomes. There remains a lack of knowledge about how these young workers experience and make sense of their early employment, particularly with