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Induction of enucleation in primary and immortalized erythroid cells
Enucleation is a crucial event during the erythropoiesis, implicating drastic morphologic and transcriptomic/proteomic changes. While many genes deletion lead to failed or impaired enucleation have been identified, directly triggering the erythroid maturation, particularly enucleation, is still challenging. Inducing enucleation at the desired timing is necessary to develop efficient methods to gen
Early history of skin preservation and transplantation; the role of Carl August Ljunggren
During the late 19th and the early 20th century there was an unprecedented development in medical research. Tissue and cell culture rapidly developed into areas with many contributing scientists. The same is true for tissue transplantation. When these achievements are described afterwards in a historical context and a mainline development is constructed, there are researchers whose pioneering work
Being innovative, fun, and green? Hedonic and environmental motivations in the use of green innovations
This paper seeks to determine the decision-making route relating to hedonic and environmental motivation in green innovation adoption and to show how two similar green innovations can motivate consumers differently. It also aims to determine the effect of domain-specific innovativeness (DSI) on emotions and green identity on environmental motivations. The paper focuses on two types of green transp
Regarding Iodixanol for Pediatric CTA. Comment on Pop, M. Cardiothoracic CTA in Infants Referred for Aortic Arch Evaluation—Retrospective Comparison of Iomeprol 350, Ioversol 350, Iopromide 370 and Iodixanol 320. Children 2021, 8, 949
Clonal Hematopoiesis and CKD Progression
Associations Between Addictive Behaviors, Individual Characteristics, and the Use of Gambling Services Within the World of Gaming : Cross-sectional Survey Study
Background: Gambling within the world of gaming is an emerging phenomenon that may share common conceptual characteristics with traditional forms of gambling. The current literature suggests a higher degree of problematic behaviors in this gambling pattern, but studies are few, prompting for further research regarding individual characteristics and comorbid conditions associated with this activity
Reproductive Health in Chronic Kidney Disease : The Implications of Sex and Gender
Chronic kidney disease (CKD) is frequently accompanied by reproductive health challenges in females and males alike. Progression of CKD is associated with escalating impairment of the hypothalamic–pituitary–gonadal axis, which facilitates evolving ovarian, testicular, and sexual dysfunction. Common clinical reproductive health complications in CKD include abnormal menstruation, impaired sexual hea
A combination of two or more unhealthy lifestyle factors is associated with impaired physical and mental health in patients with spondyloarthritis : a cross-sectional study
Background: There is increasing knowledge of how individual lifestyle factors affect patients with spondyloarthritis, while studies exploring the combination of unhealthy lifestyle factors are lacking. Thus, our aim was to study the frequency of two or more unhealthy lifestyle factors and their associations with physical and mental health in patients with spondyloarthritis (SpA). Methods: A popula
Reply to Letter to the Editor : Regular body imaging screening should be required for all children following anorectal malformation repair
Spatial clustering of trumpetfish shadowing behaviour in the Caribbean Sea revealed by citizen science
The West Atlantic trumpetfish (Aulostomus maculatus) performs an unusual hunting strategy, termed shadowing, whereby a trumpetfish swims closely behind or next to another ‘host’ species to facilitate the capture of prey. Despite trumpetfish being observed throughout the Caribbean, observations of this behaviour appear to be concentrated to a handful of localities. Here we assess the degree of geog
Climatic variation drives loss and restructuring of carbon and nitrogen in boreal forest wildfire
The boreal forest landscape covers approximately 10% of the earth's land area and accounts for almost 30 % of the global annual terrestrial sink of carbon (C). Increased emissions due to climate-change-amplified fire frequency, size, and intensity threaten to remove elements such as C and nitrogen (N) from forest soil and vegetation at rates faster than they accumulate. This may result in large ar
In situ X-ray reflectivity and GISAXS study of mesoporous silica films grown from sodium silicate solution precursors
An environmentally friendly and inexpensive silica source, sodium silicate solution, was applied to synthesize a free-standing mesoporous silica film at the air/liquid interface, exploiting the co-assembly of cetyltrimethylammonium bromide and polyethylenimine. The effect of the composition of the solution used for the film formation on the mesostructure of the as-synthesized silica films, charact
The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study
Hypothesis: Self-assembly of amphipathic styrene maleic acid copolymers with phospholipids in aqueous solution results in the formation of ‘nanodiscs’ containing a planar segment of phospholipid bilayer encapsulated by a polymer belt. Recently, studies have reported that lipids rapidly exchange between both nanodiscs in solution and external sources of lipids. Outstanding questions remain regardin
Neutron Diffraction Study of Indole Solvation in Deep Eutectic Systems of Choline Chloride, Malic Acid, and Water
Deep eutectic systems are currently under intense investigation to replace traditional organic solvents in a range of syntheses. Here, indole in choline chloride-malic acid deep eutectic solvent (DES) was studied as a function of water content, to identify solute interactions with the DES which affect heterocycle reactivity and selectivity, and as a proxy for biomolecule solvation. Empirical Poten
Fluorescent styrene maleic acid copolymers to facilitate membrane protein studies in lipid nanodiscs
Fluorescently-labelled variants of poly(styrene-co-maleic acid), SMA, have been synthesised by RAFT copolymerisation. We show that low ratios of vinyl fluorophores, analogous to styrene, can be successfully incorporated during polymerisation without detriment to nanodisc formation upon interaction with lipids. These novel copolymers are capable of encapuslating lipids and the model membrane protei
Cellulose Microbeads : Toward the Controlled Release of Nutrients to Plants
The use of conventional fertilizers is associated with pollution due to leaching and a mismatch between release rates and crop requirements for optimal development. Slow-release fertilizers could address both problems. Here, the synthesis and properties of a zinc fertilizer composed of cellulose microbeads loaded with aqueous ZnSO4 are reported for the first time. UV-vis spectrophotometry showed t
Stable Cellulose Nanofibril Microcapsules from Pickering Emulsion Templates
Electrostatic attractions are essential in any complex formation between the nanofibrils of the opposite charge for a specific application, such as microcapsule production. Here, we used cationized cellulose nanofibril (CCNF)-stabilized Pickering emulsions (PEs) as templates, and the electrostatic interactions were induced by adding oxidized cellulose nanofibrils (OCNFs) at the oil-water interface
Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first functional investigation of the mammalian insulin receptor which was extracted from cell membranes using poly(st