Filetype
Aneurysmal subarachnoid haemorrhage (SAH) is a haemorrhagic stroke that causes approximately 5% of all stroke incidents. We have been working on a treatment strategy that targets changes in cerebrovascular contractile receptors, by blocking the MEK/ERK1/2 signalling pathway. Recently, a positive effect of trametinib was found in male rats, but investigations of both sexes in pre-clinical studies a
The surface temperature of a burner nozzle using three different pilot hardware configurations was measured using lifetime phosphor thermometry with the ZnS:Ag phosphor in a gas turbine model combustor designed to mimic the Siemens DLE (Dry Low Emission) burner. The three pilot hardware configurations included a non-premixed pilot injection setup and two partially premixed pilot injections where o
Conspiracy theories accompany the emergence of infectious diseases and the 2022 multi-country monkeypox (MPX) outbreak is no exception. It is possible that the adoption of conspiracy beliefs negatively impacts health behavior. We aimed to assess the prevalence of conspiratorial attitudes towards emerging virus infections (EVIs) and the response measures aiming to control these infections among the
Background: The risk of pyelonephritis following uncomplicated lower urinary tract infection (cystitis) in women has not been studied in well-powered samples. This is likely due to the previous lack of nationwide primary healthcare data. We aimed to examine the risks of pyelonephritis following cystitis in women and explore if antibiotic treatment, cervical cancer, parity, and sociodemographic fac
β-Mannan is abundant in the human diet and in hemicellulose derived from softwood. Linear or galactose-substituted β-mannan-oligosaccharides (MOS/GMOSs) derived from β-mannan are considered emerging prebiotics that could stimulate health-associated gut microbiota. However, the underlying mechanisms are not yet resolved. Therefore, this study investigated the cross-feeding and metabolic interaction
We revisit the possibility that dark matter is composed of stable scalar glueballs of a confining dark SU(3) gauge theory coupled only to gravity. The relic abundance of dark glueballs is studied for the first time in a thermal effective theory accounting for strong-coupling dynamics. An important ingredient of our analysis is the use of an effective potential for glueballs that is fitted by latti
Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades are known to modify actin at Arg177; but of the 14-3-3 dependent exotoxins only Aeromonas salmonicida exoenzyme T (AexT) has been reported to ADP-ribosylate actin. Given the extensive similarity among the 14-3-3 dependent exotoxins, we initi
Do personality traits in highly intelligent individuals relate to their work engagement? Seemingly little is known about the relationship between personality and work engagement for gifted individuals. In what may be the first study to do so, a Swedish Mensa sample (n = 353) was explored with a two-part aim: to assess psychometric personality properties and to investigate the relationship between
In his late writings Husserl emphasizes how the semiotic properties of writing, and of mathematical formulae and diagrams, are crucial for the historical, cross-generational survivability of meaning and specifically indispensable to the operation of scientific knowledge. However, the demand for objectivity, exactitude, and repeatability insidiously interferes with the meaning that such signs seek
This article analyzes how Hindu nationalists employ fantasy narratives to counteract resistance, with a particular focus on narratives of ‘motherhood’ and ‘pseudoscience’. It does so by first introducing a conceptual discussion of the relationship between fantasy narratives, ontological insecurity, gender, and anti-science as a more general interrelationship characterizing pre- and post-COVID-19 f
DNA-encoded chemical libraries (DECLs) interrogate the interactions of a target of interest with vast numbers of molecules. DECLs hence provide abundant information about the chemical ligand space for therapeutic targets, and there is considerable interest in methods for exploiting DECL screening data to predict novel ligands. Here we introduce one such approach and demonstrate its feasibilit
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms and cellular affectation, making their study complicated due to the lack of proper animal models that fully mimic human diseases and the poor availability of post-mortem human brain tissue. Adult human nervous tissue culture offers the possibility to study different aspects of neurological disorders. Molecular, cel
Analyzing the deformation of liquid surfaces to better understand, for example, wave generation in oceanology or the formation of industrial spray systems, requires a series of three-dimensional snapshots that temporally resolve such events. This requirement is challenging, especially when applied to transient liquid surfaces that deform rapidly. A technique called Fringe Projection-Laser Induced
Demand-responsive control of electrically heated hot water storage tanks (HWSTs) is one solution, already present in the building stock, to stabilise volatile energy networks and markets. This has been put into sharp focus with the current energy crisis in Europe due to reduced access to natural gas. Furthermore, increasing proportions of intermittent renewable energy will likely add to this volat
Urban heat sources from urban infrastructure and buildings could meet ~10% of the European building heating demand. There is, however, limited information on how to use them. The EU project ReUseHeat has generated much of the existing knowledge on urban waste heat recovery implementation. Heat recovery from a data center, hospital and from water were demonstrated. Additionally, the project generat
Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta
OBJECTIVES: To describe clinical characteristics and prognosis related to heart failure (HF) phenotypes in a community-based population by applying a novel algorithm to obtain ejection fractions (EF) from electronic medical records. DESIGN: Retrospective population-based cohort study. SETTING: Data were collected for all patients with HF in Southwest Sweden. The region consists of three acute care
The rewriting of hagiographical texts was a common activity in Byzantium. From at least the ninth century until the end of the Byzantine era, ecclesiastical and non-ecclesiastical writers turned repeatedly to this form of writing, in some cases evidencing an astonishingly prolific textual output. Metaphrasis is the only word found in Byzantine titles to indicate a rewritten text but never used to
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types a
