The aim of this study was to explore how general practitioners cope with the challenges they face when trying to provide effective interventions to pain patients within the organizational context of a health center. Based on interviews with 15 Swedish providers, the study suggests that the challenges that general practitioners experience in the consultations with patients must be understood in a tThe aim of this study was to explore how general practitioners cope with the challenges they face when trying to provide effective interventions to pain patients within the organizational context of a health center. Based on interviews with 15 Swedish providers, the study suggests that the challenges that general practitioners experience in the consultations with patients must be understood in a t

Från politiskt håll finns idag en tydlig politisk intention att studenter med funktionshinder ska inkluderas i högskolornas och universitetens utbildningar. Denna artikel tar upp vad som hindrar respektive möjliggör att dessa politiska intentioner om tillgänglighet och mångfald implementeras i undervisningen. Analysen baseras på en fallstudie av en samhällsvetenskaplig institution vid ett svenskt

Artikeln berör problematiken om hur tjänstemän reagerar på förändringar i sin yrkesroll. Som specifikt fall används kampen mot ohälsan och Försäkringskassans handläggare. Författaren, Stina Hall, är doktorand vid Lunds universitet i ämnet statsvetenskap. Studien som redovisas är en del av ett större projekt om tjänstemannaroller i förändring.

Background: To demonstrate extended protection against meningococcal serogroup B (MenB) disease after MenB-FHbp (bivalent rLP2086) vaccination, this study evaluated immunopersistence through 26 months following MenB-FHbp boosting after 2 or 3 primary doses in adolescents. Study design: This phase 3, open-label study was an extension of 3 phase 2 studies with participants aged 11–18 years randomize

Background: Group B Streptococcus (GBS) is the leading cause of life-threatening infections in new-borns and may cause invasive disease, stillbirth and preterm delivery during pregnancy. While no licensed vaccine exists, maternal immunization might protect against neonatal disease and adverse pregnancy outcomes. We assessed the safety and immunogenicity of a prototype vaccine consisting of the fus

Hematopoietic stem cells (HSCs) are typically characterized by transplantation into irradiated hosts in a highly perturbed microenvironment. Here, we show that selective and temporally controlled depletion of resident HSCs through genetic deletion of Gata2 constitutes efficient recipient conditioning for transplantation without irradiation. Strikingly, we achieved robust engraftment of donor HSCs

High salt concentration has been shown to induce increased electrochemical stability in organic solvent-based electrolytes. Accompanying the change in bulk properties is a structural ordering on mesoscopic length scales and changes in the ion transport mechanism have also been suggested. Here we investigate the local structure and dynamics in highly concentrated acetonitrile electrolytes as a func

Around the world Covid-19 has been battled by trying to get the public to change how they behave: to reduce social interactions and the risks associated with them. In order to change behaviour it is not enough, however, to simply tell people what to do. Successful interventions also need to communicate how to do it. Here I dis-cuss the difference between nudges (influencing behaviour) and boosts (

In the early Holocene, Mesolithic hunter-gatherer communities inhabiting the Cis-Baikal region of Eastern Siberia were participating in a series of important cultural changes. These included the establishment of large cemeteries in the Angara Valley and on the Southwest shores of Lake Baikal, culminating in the formation of the distinctive Early Neolithic Kitoi cultural pattern ca. 7560 cal. BP. A

Although sled dogs are one of the most specialized groups of dogs, their origin and evolution has received much less attention than many other dog groups. We applied a genomic approach to investigate their spatiotemporal emergence by sequencing the genomes of 10 modern Greenland sled dogs, an ~9500-year-old Siberian dog associated with archaeological evidence for sled technology, and an ~33,000-ye

Pottery technology, originating in Northeast Asia, appeared in Alaska some 2800 years ago. It spread swiftly along Alaska's coastline but was not adopted on Kodiak Island until around 500 cal BP, as part of the Koniag tradition. While in the southeast pottery was used extensively, people on the northern half of the island did not adopt the technology. What drove these patterns of adoption and non-

Hamanaka 2 is a multi-phase coastal site in Rebun Island with a ~ 3000-year occupation sequence extending from the final-stage Jōmon and Okhotsk to the Ainu Culture period (1050 BCE-1850 CE). To examine long-term trends in food processing at the site, we collected 66 ceramic sherds across six distinct cultural layers from the Final Jōmon to the Late Okhotsk period for lipid residue analysis. Given

This abstract is based on a pilot study from an ongoing project focusing the implementation of a digital platform offering support for both the patient- and workflow at a primary healthcare center in Western Sweden. The overarching aim of the project is to follow the introduction and adaptation (normalization) of the platform in primary healthcare centers to study how digital support of the patien

Modern Arctic Indigenous peoples face many interconnected pressures, not the least of which is anthropogenic climate change, which is emerging as one of the most dramatic drivers of social and economic change in recent memory. In this paper, we investigate whether or not insights into premodern strategies for coping with climate change—and especially the “deeper histories” of traditional ways-of-k

Special Issue Editorial

We briefly review the various machine learning methods and discuss how they can be used in efficient identification and analysis of spectroscopic binary stars. They can be treated as complementary to conventional methods, and we argue that some amount of human oversight is always needed and in fact highly beneficial when employing machine learning. We propose that a general dimensionality reductio

Purpose: The purpose of this study is to discuss the concept of information in relation to temporality within the context of climate change communication. Furthermore, the paper aims to highlight the empirical richness of information as a concept by analysing its use in context. Design/methodology/approach: The discussion is based on 14 semi-structured interviews with initiators and collaborators

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes coding for ribosomal proteins. Among these genes, the ribosomal protein S19 (RPS19) gene is the most frequently mutated. Previously, a mouse model deficient in RPS19 was developed by our laboratory, which recapitulates the hematopoietic disease phenotype by manifesting pathologic f