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Objective: To examine the current status and future perspectives of prostate cancer (PCa) screening. Methods: We conducted a narrative review of randomized controlled trials focused on PCa screening and treatment. This review specifically focused on population-based trials enrolling men at average risk of PCa. Results: Prostate-specific antigen has been the cornerstone of PCa screening since its c
Reactive oxygen species (ROS)-induced aberrant oncogenic signalling has been proposed to mediate the progression and development of pleural mesothelioma (PM). In this study, we demonstrate how ROS promote oncogenic signalling, especially in the context of cell migration and immune evasion via YB-1 phosphorylation in mesothelial and PM cell models. Xanthine (X)- and xanthine oxidase (XO)-generated
Objective: To report initial experience using endografts with exclusively retrograde inner branches for endovascular aortic arch repair. Methods: A retrospective review of endovascular aortic arch repairs using custom made endografts exclusively integrating retrograde inner branches (Cook Medical, Brisbane, Australia) was conducted across seven tertiary centres (June 2022 and December 2024). Prima
Background: Emerging evidence suggests that COVID-19 may influence obstructive sleep apnea (OSA) pathophysiology by affecting upper airway collapsibility, ventilatory control, and arousal responses, raising the possibility of a bidirectional relationship. This study examined whether individuals with a history of COVID-19 show altered OSA-related physiological traits compared with those without pri
Background: Ambulatory oxygen therapy is prescribed for patients with chronic lung diseases who experience exertional hypoxemia. However, available devices may not adequately meet user requirements, and their performance characteristics are heterogeneous. Objective: This study aims to identify devices available for delivery of ambulatory oxygen therapy, the technologies that they use to generate o
We discuss two variations of Edwards’ duality theorem. More precisely, we prove one version of the theorem for cones not necessarily containing all constant functions. In particular, we allow the functions in the cone to have a non-empty common zero set. In the second variation, we replace suprema of point evaluations and infima over Jensen measures by suprema of other continuous functionals and i
Context. The Milky Way nuclear star cluster (MWNSC) is located in the Galactic centre, together with the Milky Way nuclear stellar disc (MWNSD), and they dominate the gravitational potential within the inner 300 pc. However, the formation and evolution of the two systems and their possible connections are still under debate. Aims. We reanalysed the low-resolution KMOS spectra in the MWNSC with the
There is a major contradiction between the current model of international elite sport and efforts to mitigate climate change. This study investigates climate action delay discourses within the sports sector by analyzing 28 semi-structured interviews with athletes and sports federation employees. Based on the two climate delay discourse typologies of Lamb et al. (2020, Global Sustainability, 3: e17
Cardiovascular prevention guidelines are based on robust evidence, yet their implementation in primary healthcare remains inconsistent due to systemic barriers, workload pressures and insufficiently adapted tools. The 2025 European consensus emphasizes the need for multidisciplinary teamwork, digital innovation and equity-focused strategies to strengthen prevention across diverse healthcare system
Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s
This exposition takes as its departure the systemic inertia identified within Western Higher Music Education (HME), where education is driven by skill acquisition in a master–pupil format. Such approaches may hinder the growth of adaptable and reflective musicians. We propose an alternative: student-centred learning inspired by artistic research methods. To explicate this, we draw on findings thro
Improviserad liveföreställning där gästerna/publiken bjuds in att medskapa delar av innehållet.Improviserad operaföreställning i tre akter i nära dialog med publiken. Fem sångare och pianist. Glen Miller Café i Stockholm
Performance featuring spherical amplification.Aktionshalle Stanzerei, Baden (CH)Ensemble für neue Musik Zürich06/11/2024From the Program:Haas, Lorenz (*1968, CH) – Nichts Schöneres (a Schumann song recital in fourteen scenes for seven instruments and voice) [2024]
Artificial intelligence (AI) is set to transform the care of women with cancer. From early detection via digital phenotyping to diagnosis, treatment, and follow-up, innovative AI applications are rapidly emerging across the cancer care continuum. AI-assisted mammographic screening for breast cancer has been clinically translated, and AI-based contouring in radiotherapy is streamlining treatment pl
Rates of molecular, phenotypic, and lineage diversification typically scale negatively with time interval of measurement, raising longstanding questions about time-dependency of evolutionary processes. These patterns and their potential meaning have recently re-entered evolutionary discussions. In this Perspective, we revisit the general challenges in interpreting rate–time relationships. Much app
BACKGROUND: A growing body of evidence links microRNAs (miRNAs) to major depressive disorder (MDD). However, the causal nature of these associations remains unclear.OBJECTIVES: This study aimed to investigate the potential causal association between miRNAs and MDD by combining Mendelian Randomization (MR) analyses and experimental validation.METHODS: Single-nucleotide polymorphisms (SNPs) signific
Performance featuring spherical amplification.Bludenzer Tage zeitgemäßer MusikRemise, Bludenz (AT)Ensemble Phace26/09/2024From the program:Romitelli, Fausto (1963-2004, IT) – Professor Bad Trip (for ensemble and electronics) [1998-2000]
Importance Even within individuals who are amyloid positive, clinical symptoms can be impacted by Alzheimer pathology, other pathologic proteins, and cognitive reserve or resilience. Understanding how each of these factors contributes to a patient’s clinical presentation is crucial for prognosis and treatment decisions in the era of disease-modifying therapies. Objective To evaluate tau-clinical m
Building resilient and sustainable energy systems is a critical challenge for disaster-prone regions in the Global South. This study investigates the energy management of a networked microgrid (NMG) system on Lombok Island, Indonesia, a region frequently exposed to natural disasters (NDs) and characterized by vulnerable grid infrastructure. A multi-objective optimization framework is developed to
Sustainability has received increasing attention in recent years, particularly surrounding concerns of poverty in the Global South, the climate emergency, the loss of biodiversity, and the COVID-19 pandemic. Competition and public authorities are more frequently encountering sustainability questions, while states are more generally called upon to foster sustainability by the UN Resolution 70/1. Ag
