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Caenorhabditis elegans naturally inhabits low-oxygen environments but is typically studied at 21% oxygen. We cultured adult C. elegans at 2.5%, 5%, and 21% oxygen during the fertile period, quantifying daily output of hatched larvae, unfertilized oocytes, and abnormal progeny (unhatched embryos, dead or deformed larvae). While we found no evidence for increased fertility at low oxygen levels co
IntroductionA brain raspberry is a microvascular formation of yet insufficiently known origin and significance, defined histologically as three or more transversally sectioned vascular lumen surrounded by a common perivascular space. Previous reports on the prevalence of this structure have been based mainly on histopathological routine staining with haematoxylin-eosin (HE). The aim of this study
INTRODUCTIONGlobally, 20% of women who become pregnant are obese at the time of conception. The prevalence of women becoming pregnant after gastric bypass (GBP) surgery has been increasing. Little is known regarding women’s experiences of pregnancy after GBP surgery and midwives can expect to care for an increasing number of women with prior GBP surgery. Midwives play an important role in supportiIntroduction: Globally, 20% of women who become pregnant are obese at the time of conception. The prevalence of women becoming pregnant after gastric bypass (GBP) surgery has been increasing. Little is known regarding women's experiences of pregnancy after GBP surgery and midwives can expect to care for an increasing number of women with prior GBP surgery. Midwives play an important role in suppor
INTRODUCTION: Meaningful validation of artificial intelligence for medical image interpretation requires comparison against human expert performance, yet multi-rater frameworks establishing such comparisons remain uncommon.METHODS: We developed and applied a consensus framework using nine clinicians who independently segmented the femoral nerve on 100 ultrasound images, yielding 900 annotations an
The growth of e-commerce has transformed consumer shopping patterns and reshaped travel behaviour, yet knowledge is limited regarding how different delivery options interact with individual mobility in everyday life. This study analysed how delivery options, trip characteristics, and socio-demographic and spatial factors relate to e-commerce activity travel and the degree of consumer involvement i
Introduction: Same-day discharge after primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) is increasing, but the optimal anaesthetic technique for outpatient pathways remains uncertain. Neuraxial anaesthesia is widely recommended based on observational evidence, whereas fast-track programmes using short-acting total intravenous anaesthesia may facilitate early mobilisation and
Background: Polymerase chain reaction (PCR) applications including sequencing rely on thermostable DNA polymerases and their ability to generate accurate amplicons. Polymerization errors may hinder the detection of low-level DNA variants such as mutations in clinical samples or DNA from minor contributors in crime scene traces with DNA from multiple individuals. Short Tandem Repeat (STR) markers a
BACKGROUND: – Optimal analgesia after total hip arthroplasty (THA) remains uncertain. This trial evaluated whether adding ultrasound-guided pericapsular nerve group (PENG) and iliohypogastric nerve blocks (IHGNBs) to standardized multimodal analgesia improves postoperative analgesia after THA. METHODS: – In total, 215 patients undergoing THA were randomized to receive PENG plus IHGNB or no block.
Polymorphonuclear leukocytes (PMNs), predominantly neutrophil granulocytes, are key components of the innate immune system that eliminate invading pathogens through phagocytosis and clear apoptotic cells through efferocytosis. Beta-2-microglobulin (β2m) is best known as the light chain of major histocompatibility complex class I (MHC I), where it is required for antigen presentation to CD8⁺ T cell
The increasing demand for advances in efficient electrochemical (EC) energy conversion requires a fundamental understanding of the EC interface, which is challenging to study in situ. High-resolution ambient-pressure X-ray photoelectron spectroscopy, in combination with an EC cell, has been used in a dip-and-pull approach to study the EC oxidation of a Au(111) model electrode during oxidation and
Elucidating the spatiotemporal dynamics and primary controls of flow and sediment processes (FSP) is essential for sustainable water-soil resource management in inland river basins within agro-pastoral ecotones (IRB-APE). This study refined the Soil and Water Assessment Tool with a time-segmented dynamic parameter adjustment strategy to simulate runoff and sediment dynamics under varying radiative
Ptychography with an extreme ultraviolet high harmonic source has emerged as a key technique for non-destructive microscopic imaging. However, achieving both high resolution and a large field of view in ptychographic imaging necessitates long scan times and vast data volumes. Here, we report a wavelength-multiplexed multi-beam ptychography that fully leverages the intrinsic spectral discreteness o
Background: Idiopathic normal pressure hydrocephalus (iNPH) is treated with shunt surgery, but long-term monitoring of shunt function and complications remains challenging. Traditional radiological measures such as the Evans index lack sensitivity for detecting subtle longitudinal ventricular changes. Ventricular volumetry may provide a more precise method, but prospective long-term data are scarc
P-wave indices derived from the surface electrocardiogram are increasingly used as markers of atrial cardiomyopathy and predictors of atrial fibrillation and stroke. Their widespread adoption has been driven by automated ECG analysis, enabling large-scale studies and integration into clinical workflows. However, this expansion has occurred without sufficient scrutiny of the methodological assumpti
The impact of salvage radiotherapy (SRT) on overall survival (OS) in patients experiencing biochemical recurrence (BCR) of prostate cancer remains an area of active investigation. The international multicenter PROMISE registry provides a valuable dataset to explore the association between SRT and long-term clinical outcomes in this patient population (NCT06320223). Methods: Comprehensive restaging
Background: Calcitonin gene-related peptide (CGRP) is a central mediator in migraine and an endogenous vasodilator in the trigeminovascular system. Its role in subarachnoid hemorrhage (SAH), remains uncertain, particularly in patients receiving CGRP-targeted migraine therapy at the time of hemorrhage. This study examined whether CGRP blockade administered shortly before experimental SAH affects ou
Recombining regions of sex chromosomes, pseudoautosomal regions (PARs), are essential for proper segregation of the sex chromosome pair during meiosis. Yet, the evolutionary dynamics of PARs remain poorly understood, particularly in relation to chromosomal translocation and fusion events. Using comparative analyses of enlarged neo-sex chromosomes across Sylvioidea songbirds, we show that the ances
Preparation for Reuse (PfR) encompasses activities such as reuse, repair, refurbishment, remanufacturing, and repurposing, occupying a priority position within the waste management hierarchy by enabling the extension of the useful life of products and materials with lower additional consumption of resources and energy when compared to recycling and energy recovery. Despite its relevance, PfR remai
