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Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed for this work. We review the possibilities and limitations of currently available human beta cell models and how they can be dramatically enhanced using genome-editing technologies
This essay attempts to explore what being fat means in relation to health and illness for overweight and non-overweight children aged 8-12 years. It illustrates that overweight children experience being fat as a social problem and not merely as a medical or Health problem. Their concept of overweight is influenced by the beliefs that are present in the World around them and the problems they face
Dominant narratives of prescription opioid misuse (POM) in the U.S. have portrayed it as an issue primarily affecting White communities. In this study we explore POM as reported in data from the 2015 National Survey on Drug Use and Health, using an intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). We map the risk of POM through a series of multile
IntroductionSlow sand filtration is an established method for drinking water treatment, however, the knowledge about their microbial ecology remains limited. Maintenance of slow sand filters (SSF) includes washing to remove biofilm growth in the sand and restore flow through the filter. Understanding how this impacts produced water is important as the SSF may influence the bacterial flora in the f
Aims: The aim of this study was to test a Child-Centred Health Dialogue model for primary prevention of obesity for 4-year-old children in Child Health Services, for its feasibility and the responsiveness of its outcomes.Methods: A feasibility study was set up with a non-randomised quasi-experimental cluster design comparing usual care with a structured multicomponent child-centred health dialogue
Selected find spots along the Swedish coast of the Baltic Sea are presented, in order to illustrate different ways in which hunter-gatherer societies related to the coast during the Mesolithic. Transformations of the landscape were mainly due to isostatic and eustatic changes. In the northern part, the land rose, forming new coasts and archipelagos at a speed that was noticeable even within one ge
This article examines the historical genesis, nature, features and international legal status of the Institute representation at the UN, both on the territory of the member states and of the member states to the UN. An attempt was made to reveal the status and characteristics of the offices of both the UN and its specialized agencies. On the basis of the analysis, proposals were made to strengthen
