Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes

Purpose: To evaluate the potential for right ventricular reverse remodelling after pulmonary valve replacement using cardiac magnetic resonance imaging, in adults with corrected tetralogy of Fallot and severe pulmonary insufficiency. Material and methods: Ten patients with previous correction of tetralogy of Fallot with severe pulmonary insufficiency accepted for pulmonary valve replacement were

Context: Open tools (e.g., Jenkins, Gerrit and Git) offer a lucrative alternative to commercial tools. Many companies and developers from OSS communities make a collaborative effort to improve the tools. Prior to this study, we developed an empirically based theory for companies’ strategic choices on the development of these tools, based on empirical observations in the telecom domain. Aim: The ai

We report the first examples of the carbide ligand in (Cy 3 P) 2 Cl 2 Ru≡C (RuC) developing into a μ 3 ligand toward metal centers. Conventionally, sterics exclude this coordination mode, but Fe 2 (CO) 9 and Co 2 (CO) 8 expel bridging CO ligands upon reaction with RuC to form trimetallic (Cy 3 P) 2 Cl 2 Ru=CFe 2 (CO) 8 (RuCFe 2 ) and (Cy 3 P) 2 Cl 2 Ru=CCo 2 (CO) 7 (RuCCo 2 )

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess whether continuous glucose monitoring (CGM) versus any intermittent monitoring modalities to measure glycemia improves neurodevelopmental outcomes in preterm newborn infants.

In this research, a methodology was applied to integrate hydraulic simulation model, HEC-RAS and GIS analysis for delineation of flood extents and depths within a selected reach of Zaremroud River in Iran. Floodplain modeling is a recently new and applied method in river engineering discipline and is essential for prediction of flood hazards. It is necessary to simulate complicated hydraulic behav

På uppdrag av länsstyrelserna i Dalarna, Jämtland och Gävleborgs län har Avdelningen för Riskhantering och Samhällssäkerhet vid Lunds Universitet utvärderat hur länsstyrelserna hanterade de omfattande skogsbränderna under sommaren 2018. Syftet med utvärderingen har varit att analysera hur länsstyrelserna tillsammans bidrog till inriktning och samordning av samhällets samlade resurser. Med utgångsp

In this research a method to calibrate a river hydraulic model (HEC-RAS) using ground-based measurements of an observed flash flood is presented. Applications of the ground truth measurement of flood water depths and flooded areas within a reach of Neka River in Northern of Iran are discussed. The model is calibrated using the Manning's roughness coefficient based on 200-year flood event that took

This study presents the results of open-ended contingent valuation method (CVM) to estimate the residents' maximum willingness to pay (WTP) for flood insurance and structural flood control measures in the Neka River Basin in Northern Iran. Flood inundation analysis and floodplain risk mapping were conducted by applying the HEC-RAS model combined with GIS analysis. A calibrated 100-year flood risk

While the Watson–Crick double-strand is the thermodynamically stable state of DNA in a wide range of temperature and salt conditions, even at physiological conditions local denaturation bubbles may open up spontaneously due to thermal activation. By raising the ambient temperature, titration, or by external forces in single molecule setups bubbles proliferate until full denaturation of the DNA occ

We investigate the single-file dynamics of a tagged particle in a system consisting of N hardcore interacting particles (the particles cannot pass each other) which are diffusing in a one-dimensional system where the particles have different diffusion constants. For the two-particle case an exact result for the conditional probability density function (PDF) is obtained for arbitrary initial partic

We study diffusion of (fluorescently) tagged hard-core interacting particles of finite size in a finite one-dimensional system. We find an exact analytical expression for the tagged particle probability density function using a Bethe ansatz, from which the mean square displacement is calculated. The analysis shows the existence of three regimes of drastically different behavior for short, intermed

While the statistical mechanical description of DNA has a long tradition, renewed interest in DNA melting from a physics perspective is nourished by measurements of the fluctuation dynamics of local denaturation bubbles by single molecule spectroscopy. The dynamical opening of DNA bubbles (DNA breathing) is supposedly crucial for biological functioning during, for instance, transcription initiatio

After crossing an initial barrier to break the first base-pair (bp) in double-stranded DNA, the disruption of further bps is characterized by free energies up to a few kBT. Thermal motion within the DNA double strand therefore causes the opening of intermittent single-stranded denaturation zones, the DNA bubbles. The unzipping and zipping dynamics of bps at the two zipper forks of a bubble, where