This invention relates to determining the three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. The invention also relates to methods for rational drug design enabling the design of phospholamban inhibitors based on using the three-dimensional structure data pro

PURPOSE: To describe and report the neuroradiological findings and clinical features in a patient with familial haemophagocytic lymphohistocytosis (FHL), a rare hereditary immune dysregulation in early childhood characterised by multisystem involvement, including in approximately 30% of cases also the central nervous system (CNS).MATERIAL AND METHODS: Serial brain MR examinations were carried out

A three-dimensional calculation method has been further developed to include two-phase, multi-component gas and heat transport processes. A set of momentum, heat transport and gas species equations have been solved for the whole duct by coupled source terms and variable thermophysical properties. The effects of the electrochemical reactions on the heat generation and mass consumption/generation ha

PURPOSE: The neural tolerance of the recently introduced dimer iodixanol (320 g I/l) was compared with that of the dimer iotrolan (300 g I/l) and of the monomer iopamidol (300 g I/l), both used in clinical myelography.MATERIAL AND METHODS: Non-anaesthetised rabbits were injected into the cisterna magna with Ringer's solution (control) or contrast media (CM) at doses of 1.0 or 0.5 ml/kg b.w. The be

A retrospective study was performed on 42 consecutive patients to examine the value of radiography in the management of complaints of fishbone ingestion. All patients underwent an oral examination followed by radiographic examination with plain films, barium swallows, barium and water swallows, and an endoscopic examination. All radiographs were reviewed by two unbiased, experienced radiologists.

The relationship between bolus volume (2.5, 5, 10 and 20 ml) and larynx elevation during swallowing was assessed in 10 non-dysphagic and 10 dysphagic individuals without pharyngeal dysfunction. Laryngeal elevation in different types of pharyngeal dysfunction was assessed in 60 non-dysphagic and 75 dysphagic patients. All subjects were examined with liquid barium and cineradiography at 50 frames/s.

The mass spectra from the SF6 molecule acquired by energy-resolved electron ion coincidence (EREICO) technique using (1t1g + [5t1u,1t2u]), (3eg + 1t2g), 4t1u, and 5a1g electrons after both valence and S 2p−1 6a1g core excitation reveal a strong selectivity in the dissociation from these states. From the comparison of the obtained spectra, the influence of the core-excited state in the relaxation p

The influence on the crack growth rate on a micro-structurally short edge crack subjected to fatigue loading from changes in crack length, distance to grain boundaries and applied load has been investigated. The crack is assumed to grow in a single shear mechanism due to nucleation, glide and annihilation of dislocations along preferred slip planes in the material. The external geometry is modelle

A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in relieving the inhibitory effects of phospholamban on cardiac sarcoplasmic reticulum Ca2+ -ATPase are also described.

Monoclonal antibodies have many potential therapeutic benefits. However, when applied to humans, mouse monoclonal antibodies have several disadvantages. Here Carl Borrebaeck and colleagues describe a strategy to overcome the anti-Gal activity, thought to be one of the reasons why mouse mAbs have a limited half-life.

Primary proteolysis was studied in a starter-free cheese model made from microfiltered (MF) milk (19.0% casein,

A novel isolation procedure was developed that allowed the purification of rat liver and human placenta catechol-O-methyltransferase (EC 2.1.1.6, COMT) enzyme from rat and human sources to a degree sufficient to allow the amino acid sequencing of the enzyme. Recombinant clones directed against the rat liver and human placenta COMT are identified and sequenced. The isolation of pure and recombinant

Almost all eye-movement researchers use algorithms to parse raw data and detect distinct types of eye movement events, such as fixations, saccades, and pursuit, and then base their results on these. Surprisingly, these algorithms are rarely evaluated. We evaluated the classifications of ten eye-movement event detection algorithms, on data from an SMI HiSpeed 1250 system, and compared them to manua

The purpose of this paper is to make visible different approaches to university librarians' professional expertise such as they are mediated through user information seeking education. The empirical basis of the study consists of an analysis of 31 web-based tutorials in information literacy accessible via Scandinavian university libraries' web-sites. The results make apparent four, sometimes confl

This article presents an investigation of the swirl number effects on the stability limits of various syngas compositions in an atmospheric premixed variable-swirl burner. Lean blowout (LBO) and flashback (FB) experiments were performed using fuel mixtures containing varying amounts of H2, CO and CH4 at two swirl numbers. Reducing the swirl number from 0.66 to 0.53, reduced the flashback propensit

The paper shows how parental expectations about child’s future income affect the incidence of child labour and schooling. We present a theoretical framework where parents decide on the optimal amount of time invested in child education in presence of uncertainty about returns to education. Here, the uncertainty is captured using the probability that parents attach to higher returns after education

Long-run saving dynamics are a crucial component of consumption-saving behavior. This paper makes two contributions to the consumption literature. First, we exploit inheritance episodes to provide novel causal evidence on the long-run effects of a large financial windfall on saving behavior. For identification, we combine a longitudinal panel of administrative wealth reports with variation in the