Mixed-effects models are used to describe the inter-patient variability in drugs. Modeling of these variabilities include both fixed and random effects. Fixed effects relate covariates such as age and weight to compartment volumes and clearances, whereas random effects account for unexplained variability. Traditionally, the development of fixed effects models is an inefficient process where covari

Kidney transplantation, the gold-standard therapeutic approach for patients with end-stage kidney disease, offers improvement in patient survival and quality of life. However, broad sensitization against human leukocyte antigens often resulting in a positive crossmatch against the patient’s living donor or the majority of potential deceased donors in the allocation system represents a major obstac

Understanding the evolutionary processes that influence fitness is critical to predicting species' responses to selection. Interactions among evolutionary processes including gene flow, drift and the strength of selection can lead to either local adaptation or maladaptation, especially in heterogenous landscapes. Populations experiencing novel environments or resources are ideal for understanding

Background: Person-centered care (PCC) is gaining increased attention. PCC concerns the whole person behind the disease and can improve care for people with long-term conditions such as multiple sclerosis (MS) and Parkinson’s disease (PD). However, there is a lack of tools to assess PCC from the patients’ perspective, particularly in outpatient care. The Person-Centered Care instrument for outpati

Land use allocation (LUA) is of prime importance for the development of urban sustainability and resilience. Since the process of planning and managing land use requires balancing different conflicting social, economic, and environmental factors, it has become a complex and significant issue in urban planning worldwide. LUA is usually regarded as a spatial multi-objective optimization (MOO) proble

Objectives: The randomized controlled trial comparing digital breast tomosynthesis and synthetic 2D mammograms (DBT + SM) versus digital mammography (DM) (the To-Be 1 trial), 2016–2017, did not result in higher cancer detection for DBT + SM. We aimed to determine if negative cases prior to interval and consecutive screen-detected cancers from DBT + SM were due to interpretive error. Methods: Five

This conference presentation address research processes that discusses materiality of artistic practice and its implications. Taking point of departure in the making of a physical artefact, the proposal considers the interplay between making and thinking, encompassing both the human and the non-human, resulting in co-constructed knowledge and meaning through performative and textile practices. Dr

KNYTTE BÅND was a participatory project that included three one week-long workshops at the Danish primary schools Baunehøjskolen, Absalonsskolen and Treksonerskolen where 550 children participated. At each school, the children from the middle school (4th, 5th and 6th grade) co-created one knotted textile-work. At the SWOP festival we then collected the three knotted textile-works and during the fe

Background Transcatheter aortic valve implantation (TAVI) is an increasingly important treatment option for patients with severe aortic stenosis. Its best implementation is debated, as few centres with high volumes are associated with better outcomes, while centralization might lead to an inferior availability of treatment for patients living far away. The aim of this study was to investigate the

We present calculations on the formation of 258Rf in the reaction 50Ti+208Pb within the Langevin framework. The initital stage after contact of the colliding nuclei is dominated by a drift in the center-of-mass direction, while the subsequent process of forming a compound nucleus is diffusion dominated. The probability for the composite system to diffuse over the inner saddle is obtained by perfor

Biocompatibility testing of medical devices is governed by the ISO 10993 series of standards and includes evaluation of skin sensitization potential of the final product. A majority of all medical devices are tested using in vivo methods, largely due to the lack of in vitro methods validated within the applicability domain of solid materials. The GARDskin method for assessment of chemical skin sen

Aim: Assess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA). Methods: Prospective observational multicentre substudy of the “Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial”, also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to externa

Warm dense matter is at the boundary between a plasma and a condensed phase and plays a role in astrophysics, planetary science and inertial confinement fusion research. However, its electronic structure and ionic structure upon irradiation with strong laser pulses remain poorly understood. Here, we use an intense and ultrafast X-ray free-electron laser pulse to simultaneously create and character

• Purpose: To assess utility, benefits, and risks of 4th-generation alumina–zirconia ceramic pairings in elective total hip arthroplasty (THA). • Methods: A comprehensive mixed-methods best-evidence synthesis using data from systematic reviews, randomized controlled trials (RCTs), prospective and retrospective cohort studies, as well as joint replacement registries, was conducted to estimate overa

Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity. Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity.