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Autoimmune thrombocytopenic purpura (AITP) is a bleeding disorder in which autoantibodies are directed against an individual's own platelets, leading to enhanced clearance through Fc receptor (R)-mediated phagocytosis by macrophages residing in the reticuloendothelial system, particularly in the spleen. Although the immunopathogenesis of the disease is autoantibody-mediated, there is now substanti
Chronic autoimmune thrombocytopenic purpura (AITP) is an immune-mediated, bleeding disorder in which platelets are opsonized by autoantibodies and prematurely destroyed by phagocytic cells in the reticuloendothelial system. It is classed as an organ-specific autoimmune disease primarily mediated by immunoglobulin G (IgG) autoantibodies and its etiology appears to be similar to that observed for ot
OBJECTIVES: To compare treatment retention between biosimilars and their originator products among first starters (etanercept, infliximab, adalimumab and rituximab), as well as after non-medical switch. METHODS: Patients with rheumatic diseases starting, for the first time, an originator or biosimilar etanercept, infliximab, adalimumab or rituximab were identified in the national Swedish Rheumatol
Idiopathic thrombocytopenic purpura (ITP) is characterized by the development of a specific anti-platelet autoantibody immune response mediating the development of thrombocytopenia. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of a wide variety of autoantibodies. In 15-20% of SLE cases, patients develop thrombocytopenia which appears to be autoimmune
Infusion of large amounts of intravenous immunoglobulin (IVIG) or anti-D can reverse the low platelet count in patients with ITP within hours of the initiation of treatment. In some cases, the effects of IVIG appear to far outlast several half-lives of the product. Several mechanisms have been proposed to explain these rapid and long term effects and these will be discussed in this review.
Autoimmune thrombocytopenic purpura (AITP) is a bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in enhanced Fc-mediated platelet destruction by macrophages in the reticuloendothelial system. Most research in AITP has focused on characterization of the autoantibodies, while little has been devoted to the cellular immune mechanisms leading to a
Chronic autoimmune thrombocytopenic purpura (ATP) is a common autoimmune-mediated bleeding disease in which autoantibodies are directed against platelets, resulting in their enhanced Fc-mediated destruction by macrophages in the spleen. While there has been extensive studies relating to the autoantibodies in this autoimmune disorder, relatively few have dealt with cell-mediated immunoregulation of
Giant honeybees, including the open-nesting Asian giant honeybee Apis dorsata, display a spectacular collective defence behaviour - known as 'shimmering' - against predators, which is characterised by travelling waves generated by individual bees flipping their abdomens in a coordinated and sequential manner across the bee curtain. We examined whether shimmering is visually mediated by presenting
Abstract in TurkishHazreti Muhammed’in ailesi (Ehl-i Beyt), Şii mezhebi inancında merkezi bir konuma sahiptir. Bu dünyada şefaat edebilecek gayri maddi varlıklar olarak, Müslümanların hayatlarına tanık oldukları ve onlarla birlikte bulundukları söylenir. Ne yazık ki antropolojide, bu gibi gayri maddi ve insan-ötesi varlıklarla ilişkiler ihmal edilmektedir. Bu makale, insan-ötesi varlıkları sadece The Family of the Prophet Muhammad holds a central position in Shiʿi Muslim religiosity. As immaterial beings able to intercede in this world, they are said to be witnessing and co-present in the lives of Muslims. Anthropology has neglected relations with immaterial more-than-human beings like these. Instead of regarding them merely as symbols or moral exemplars, this essay focuses on the cultivat
Bakgrund: Tidig diagnos och behandling av bröstcancer-relaterade lymfödem(BCRL) är viktigt för att förhindra försämring och påverkan på livskvalitet. Vidmindre BCRL i arm, kan det ansamlas lymfvätska lokalt i den ytliga vävnaden, utan en volymökning. Tissue Dielectric Constant (TDC), är en metod som mäter lokal vävnadsvätska i hud och subkutan vävnad och hade inte använts tidigare för att diagnostBackground: Early diagnosis and treatment of Breast Cancer-RelatedLymphedema (BCRL) are important to prevent lymphedema progress and impacton Health-Related Quality of Life (HRQOL). The treatment includes self-care andtreatment with compression garment. In mild BCRL, the lymphedema can be local, without an increase in arm volume. Tissue Dielectric Constant (TDC), measuring local tissue water in sk
I Sverige omfattas 9 av 10 anställda av kollektivavtal. Täckningsgraden är hög, men det finns vissa branscher och typer av företag där förekomsten av kollektivavtal, av olika anledningar, är låg. Professor Anders Kjellberg vid Lunds universitet redogör för hur den svenska kollektivavtalskartan ser ut.
How well can modern wearable eye trackers cope with head and body movement? To investigate this question, we asked four participants to stand still, walk, skip, and jump while fixating a static physical target in space. We did this for six different eye trackers. All the eye trackers were capable of recording gaze during the most dynamic episodes (skipping and jumping). The accuracy became worse a
The past two decades have seen unprecedented student demand for global health education through experiential and engaged learning within institutions of higher education in the United States. This demand created a need for innovative institutional partnerships. Since 2007, faculty from Cornell University’s Global Health Program and Kilimanjaro Christian Medical University College (KCMUCo) have wor
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD). Systemic inflammation, driven by cytokines such as TNF, IL-6 and IL-17A, has been implicated as a contributing factor to CVD development in RA. The objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of CVD events in patients with early RA.Me
This essay takes those exhibits in RÊVE (Romantic Europe: The Virtual Exhibition) that are connected to “air” as points of departure for a survey of the renewed interest in air in Romantic-period cultural texts from across Europe. Scholarly interest in Romantic air has burgeoned of late but has often tended to prioritise metaphorical senses of the term or cognate terms such as atmosphere. This ess
