Deciphering cell-cell interaction between Fibroblasts and Monocytes in oligoarticular Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and is characterized by chronic synovial inflammation. Monocytes isolated from inflamed joints in oligoarticular JIA display both inflammatory and regulatory features. While some insights exist regarding signals that drive regulatory traits, the mechanisms responsible for inflammatory activation remain poorly unde