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Digitalization of the downstream process for monoclonal antibodies can be used as a tool towards more efficient and sustainable processing. One part of digitalization are digital twins, which can help provide insights into a process and be used for process optimization, reducing production costs and accelerating drug discovery. However, creating a useful digital twin is often difficult and time-co
Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegeneration, and other diseases. Despite its significance, the mechanistic details of spermine remain incompletely understood. Here, we describe the distinct modulation by spermine on Alzheimer’s Tau and Parkinson’s α-synuclein, elucidating their condensat
A piece that deals with: A. Where does the real Ecumenical debate stand today - between the confessions or rather between conservative and liberal streams of the church? B: What is the relationship between Ecumenical conversation and inter-religious conversation?
Background: Self-rated health (SRH) is an international measure and indicator of mortality and morbidity that can be used as a mortality predictor in adulthood. This study aimed to examine the status of SRH among adults in Qazvin Province and its relationship with physical activity levels and demographic factors in primary care centers. Methods: This is a cross-sectional study. We included data fr
The abundance and star formation histories of satellites of Milky Way (MW)-like galaxies are linked to their hosts' assembly histories. To explore this connection, we use the PARADIGM suite of zoom-in hydrodynamical simulations of MW-mass haloes, evolving the same initial conditions spanning various halo assembly histories with the VINTERGATAN and IllustrisTNG models. Our VINTERGATAN simulations o
An experimental study of smoke propagation from an apartment to an escape route corridor in a real-scale residential building is presented in this paper. The experiments were performed using the same experimental setup but with different ventilation and apartment door opening times. The setup consisted of a fire in a two-seater sofa in an apartment connected to a corridor and other apartments. A t
Globally, road traffic accidents (RTAs) remain a major cause of death, particularly among individuals aged 15–30 years. While Sweden has been at the forefront of traffic safety through the Vision Zero initiative, in-hospital management remains crucial in determining RTA outcomes. Drawing on North American evidence suggesting improved survival at trauma centres, the Swedish healthcare system has in
Stjärnböckerna is a book series for teenagers that was published by Svensk läraretidnings förlag 1937–1950. This article investigates the launch of the book series in 1937, the content of the first four books, their reception and the marketing of the book series, with the aim to gain a deeper understanding of how the publisher performed literary value. The study draws on theories about literary
Although adenoviruses (AdVs) possess advantageous features as vectors, several challenges remain. These include a high prevalence of neutralizing antibodies against certain AdV types and the inability to efficiently transduce CAR-deficient cells and tissues. We showed previously that lactoferricin (Lfcin) enhances CAR-independent HAdV-C5 infection of epithelial and T-cells. Here, we assessed the a
Storm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and someStorm surges combine the power of two natural hazards, strong winds and flooding, and can have devastating effects on people, infrastructure, and nature in coastal areas. Ongoing global changes, including rising sea levels and shifting storm patterns, are expected to increase both the frequency and amplitude of such events in the future. There are, however, significant regional variations and some
The Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sigThe Late Pleistocene cataclysmic releases of glacial meltwater left distinct footprint across the Central European Lowland. Deeply incised tunnel valleys, oversized ice-marginal spillways, fields of mega-dunes, and glacial curvilineations carved by rapid drainage events occur along the southern margin of the last (Weichselian) Scandinavian Ice Sheet margin. These meltwater releases contributed sig
