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Physiologically based pharmacokinetic (PBPK) models offer the ability to simulate and predict the biodistribution of radiopharmaceuticals and have the potential to enable individualised treatment planning in molecular radiotherapy. The objective of this study was to develop and implement a whole-body compartmental PBPK model for peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE

Drought is a natural disaster that occurs globally and can damage the environment, disrupt agricultural production and cause large economic losses. The accurate prediction of drought can effectively reduce the impacts of droughts. Deep learning methods have shown promise in drought prediction, with convolutional neural networks (CNNs) being particularly effective in handling spatial information. I

Influenza virus has presented a considerable healthcare challenge during the past years, particularly in vulnerable groups with compromised immune systems. Therapeutics and vaccination have always been in research annals since the spread of influenza. Efforts have been going on to develop an antiviral therapeutic approach that could assist in better disease management and reduce the overall diseas

Rescuing stalled ribosomes often involves their splitting into subunits. In many bacteria, the resultant large subunits bearing peptidyl-tRNAs are processed by the ribosome-associated quality control (RQC) apparatus that extends the C termini of the incomplete nascent polypeptides with polyalanine tails to facilitate their degradation. Although the tailing mechanism is well established, it is uncl

A collection of microswimmers immersed in an incompressible fluid is characterised by strong interactions due to the long-range nature of the hydrodynamic fields generated by individual organisms. As a result, suspensions of rear-actuated 'pusher' swimmers such as bacteria exhibit a collective motion state often referred to as 'bacterial turbulence', characterised by large-scale chaotic flows. The

BACKGROUND: Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the clinical onset, is not well understood. We previously reported that the number of circulating neutrophils is reduced in patients with T1D and in presym

In microbiological studies, a common goal is to link environmental factors to microbial activities. Both environmental factors and microbial activities are typically derived from bulk samples. It is becoming increasingly clear that such bulk environmental parameters poorly represent the microscale environments microorganisms experience. Using infrared (IR) microspectroscopy, the spatial distributi

Artikel om Folkets park och Folkets hus som kulturarv från ett samhällsplaneringsperspektiv.

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This article analyses one of the recent views adopted by the Committee on Economic, Social and Cultural Rights in the communication Infante Díaz v Spain concerning the right to adequate housing under Article 11(1) of the International Covenant on Economic, Social and Cultural Rights. This view is important, as it marks the first time the CESCR found a violation of the right to adequate housing of

High-pressure torsion (HPT) is widely used as a key method for microstructure control through deformation processing across a broad range of materials. However, certain gaps in process control impact its efficacy. In this study, we investigate the acoustic emission (AE) signals generated during HPT by considering commercially pure molybdenum as an example. By employing the adaptive sequential k-me

The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of