Development of an Antigen-independent Affinity Assay to study the Binding of IgG to FcgammaR
Fc gamma receptors (FcγRs) are membrane-bound receptors which bind the Fc fragment of antigen-bound IgGs. The binding generates cell signaling and subsequently an immunological response. In this way FcγRs are important links between the humoral and cellular parts of the immune system. Three families of FcγRs have been identified in human, FcγRI, FcγRII and FcγRIII. FcγRI has high affinity for IgG