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Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. In vitro expansion and differentiation of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons. The neurogenic potential of MSCs makes them a pr
Hedvig Eleonora (1636-1715), barockens drottning, gift med Karl X Gustav, mor till Karl XI och farmor till Karl XII. Mecenat för konst och kultur, medlem i två förmyndarregeringar. Skildring av 1600-talets Sverige, stormaktens uppgång och fall.
Purpose: To explore pressure-related effects in the adult porcine retina in vitro. Methods: Retinal explants were subjected to 0, 10, 30, or 60 mmHg of pressure for 24 or 48 hours in culture. Overall tissue damage in sections was assessed by lactate dehydrogenase media levels, hematoxylin and eosin staining, and TUNEL staining. Inner retinal neurons were evaluated by protein kinase C alpha (rod bi
Strenuous physical activity can negatively affect constitutive innate immune function (CIF), the always present first line of defence against pathogens. CIF is non-specific, and thus vital when encountering novel pathogens. A lowered CIF likely increases the risk of infection and disease. Migratory birds engage in truly extreme physical activity during their endurance flights, however, little is k
OBJECTIVES: To estimate the incidence of non-vertebral fractures in ankylosing spondylitis (AS) compared with the general population. METHODS: Nationwide register-based cohort study including patients with AS (n=11 611, 65% men, mean age 48 years), and matched general population controls (n=58 050). Five prespecified fracture outcomes: (1) non-vertebral; (2) fracture of the proximal humerus, dista
Due to the substantial gross exchange fluxes with the atmosphere, the terrestrial carbon cycle plays a significant role in the global carbon budget. Drought commonly affects terrestrial carbon absorption negatively. Terrestrial biosphere models exhibit significant uncertainties in capturing the carbon flux response to drought, which have an impact on estimates of the global carbon budget. Through
Network-based biocomputation (NBC) relies on accurate guiding of biological agents through nanofabricated channels produced by lithographic patterning techniques. Here, we report on the large-scale, wafer-level fabrication of optimized microfluidic channel networks (NBC networks) using electron-beam lithography as the central method. To confirm the functionality of these NBC networks, we solve an
Spark ablation is an advantageous method for the generation of metallic nanoparticles with defined particle sizes and compositions. The reaction of the metal particles with the carrier gas during the synthesis and, therefore, the incorporation of those light elements into structural voids or even compound formation was confirmed for hydrides and oxides but has only been suspected to occur for nitr
Introduction: The specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/L as a criterion for mild autonomous cortisol secretion (MACS) is approximately 85% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDST to age, BMI, and renal function. Methods: We studied 1,129 patients with AI examined from 2005 to 2015 at Skåne University Hosp
Three new species of Valeriana from southern Ecuador are described and illustrated. Valeriana plateadensis is found near the highest peak of Cerro Plateado in Cordillera del Cóndor at 2900 m a.s.l. and is recognized by the shrubby habit and sessile, densely imbricate, spatulate leaves and 3-lobed corollas. V. yacuriensis is found near Lagunas Negras de Jimbura in the Parque Nacional Yacurí at 3500
When creating models of a system, there is always a tradeoff between the ease of modelling a part and the increased value it brings to the model. Learning a model using machine learning instead, we are able to capture all kinds of things we don't necessarily understand, but can need large amounts of data to learn even the things we find simple. Using universal differential equations we can combine
Recent advances in the field demonstrate the high diversity and complexity of endocytic pathways. In the current study, we focus on the endocytosis of L1CAM. This glycoprotein plays a major role in the development of the nervous system, and is involved in cancer development and is associated with metastases and poor prognosis. Two L1CAM isoforms are subject to endocytosis: isoform 1, described as
