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A Reliabilism without Counterexamples and Reference Class Problems
In this article, I present a modified reliabilist theory of knowledge which purports to solve many of the problems currently facing standard reliabilism. With the help of a dispositionally construed reliabilist theory of knowledge and justification (DRK and DRJ), tentative responses to the following problems for reliabilism are offered: The New Evil Demon Problem, The Clairvoyance Problem, The Mr.
Ultrasound-assisted regeneration of ion exchange resins for efficient detoxification of lignocellulosic hydrolysate in biorefinery
Resin adsorption is an effective technology for the fermentable sugar slurry detoxification in lignocellulosic biorefinery, but with the great limitation of the loss of resin capacity from inhibitor contamination and the extensive use of acid and base solutions for their regeneration. In this study, we developed a green and practical method with ultrasound assisting the depletion of poisoned resin
Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) emerges from mutant KRAS-harboring but dormant low-grade pancreatic intraepithelial neoplasia (PanIN). To examine the role of oxidative stress, a putative PDAC risk factor, we established an organoid-based transformation system. Although the prototypic oxidant H2O2 induced organoid transformation, its effect was nonmutational and was mediated by the oxidant-
Circulating protein biomarkers and their association with vulnerable plaque characteristics – a PROSPECT II substudy
Background: In the PROSPECT-II study, near infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) was used to characterize atherosclerotic plaques in the coronary arteries. NIRS-derived lipid core burden index (LCBI) and IVUS-derived plaque burden (PB) were able to identify plaques strongly associated with adverse cardiovascular events. Aim: Our aim was to identify biomarkers associated
Statistical volume element generation for paperboard based on X-ray computer tomography images
The macroscopic response governed by a statistical volume element, generated from 3D X-ray computer tomography images of paperboard, is explored. The statistical volume element, which consists of fibres and void, is derived from X-ray computer tomography images. Two filters for computing intensity fields and intensity gradients have been implemented and compared. Using an intensity threshold, the
Anticipating airpocalypse : Air quality apps and implicit modes of anticipatory practices
Air quality apps are designed to observe air quality and inform publics about it, but also to elicit actions based on anticipated scenarios. As such, they may be seen as anticipatory technologies, cultivating environmental understandings and orienting users toward a specific future. This paper explores the anticipatory assemblages of these apps as well as users’ interactions with these apps and th
Brief Admission by Self-Referral : A 4-Year Follow-Up on Utilisation Patterns and Experiences
Brief Admission by self-referral (BA) is a crisis intervention for individuals with recurrent self-harm and suicidal ideation. While short-term effects are documented, long-term utilisation patterns remain unclear. This study examines BA usage over 4 years, identifies distinct utilisation profiles, and qualitatively explores participants' experiences with BA over time. Participants were 62 individ
Eco-friendly insect control in crop production
Insect pest control, which is essential for food and crop production, typically relies on chemical insecticides. At Yngvi Bio, we repurpose bacterial contractile injection systems as biodegradable insecticides, offering ecological safety, target specificity and a scalable path to market.
Perceptual, Semantic, and Pragmatic Factors Affect the Derivation of Contrastive Inferences
People derive contrastive inferences when interpreting adjectives (e.g., inferring that 'the short pencil' is being contrasted with a longer one). However, classic eye-tracking studies revealed contrastive inferences with scalar and material adjectives, but not with color adjectives. This was explained as a difference in listeners' informativity expectations, since color adjectives are often used
Anticipating the Damn Referent : How Comprehenders Rapidly Retrieve the Speaker's Attitude When Processing Negative Expressive Adjectives
Theoretical accounts of negative expressives such as damn have ascribed two main properties to this type of adjective, namely that they are typically speaker-oriented, and that they can be flexible with regard to their syntactic attachment. However, it is not clear what this means during online sentence processing. For example, is it effortful for comprehenders to derive the speaker's negative att
Slowdowns in scalar implicature processing : Isolating the intention-reading costs in the Bott & Noveck task
An underinformative sentence, such as Some cats are mammals, is trivially true with a semantic (some and perhaps all) reading of the quantifier and false with a pragmatic (some but not all) one, with the latter reliably resulting in longer response times than the former in a truth evaluation task (Bott & Noveck, 2004). Most analyses attribute these prolonged reaction times, or costs, to the st
Suppression of literal meaning in single and extended metaphors
Within Relevance Theory, it has been suggested that extended metaphors might be processed differently relative to single metaphoric uses. While single metaphors are hypothesized to be understood via the creation of an ad hoc concept, extended metaphors have been claimed to require a switch to a secondary processing mode, which gives greater prominence to the literal meaning. Initial experimental e
When irony is faster than its literal control : The role of mindreading during irony comprehension
Irony is a heavily context-dependent pragmatic phenomenon. But what is it about context that facilitates or blocks irony comprehension? Based on the echoic account, we suggest that a context facilitates irony comprehension when it makes manifest a speaker's intentions and attitude, i.e., when a context makes it easy for participants to engage their mindreading abilities. In two pre-registered self
The Role of Literal Features During Processing of Novel Verbal Metaphors
When a word is used metaphorically (for example "walrus" in the sentence "The president is a walrus"), some features of that word's meaning ("very fat," "slow-moving") are carried across to the metaphoric interpretation while other features ("has large tusks," "lives near the north pole") are not. What happens to these features that relate only to the literal meaning during processing of novel met
Counter-productivity and suspicion : two arguments against talking about the AGI control problem
How do you control a superintelligent artificial being given the possibility that its goals or actions might conflict with human interests? Over the past few decades, this concern– the AGI control problem– has remained a central challenge for research in AI safety. This paper develops and defends two arguments that provide pro tanto support for the following policy for those who worry about the AG
Classical Rhetorical Argumentation for the Rhetorical Critic
This book offers a reassessment of argumentation in classical rhetoric, foregrounding its rational dimension. Moving beyond introductions, it provides insights from Aristotle, Quintilian, and other ancient thinkers while addressing common misconceptions and offering clarifications that are particularly valuable for the rhetorical critic.Adopting a Scandinavian rhetorical perspective, this book arg
What second-language speakers can tell us about pragmatic processing
Upon hearing the phrase Some cats meow, a listener might pragmatically infer that 'Some but not all cats meow'. This is known as a scalar implicature and it often arises when a speaker produces a weak linguistic expression instead of a stronger one. Several L2 studies claim that pragmatic inferences are generated by default and their comprehension presents no challenges to L2 learners. However, th
Register and morphosyntactic congruence during sentence processing in German : An eye-tracking study
In the present study, we used eye-tracking to investigate formality-register and morphosyntactic congruence during sentence reading. While research frequently covers participants' processing of lexical, (morpho-)syntactic, or semantic knowledge (e.g., operationalized by means of violations to which we can measure responses relative to felicitous stimuli), less attention has been devoted to the ful
Moving beyond Porter, Fanning, and Campbell : A Linguistically Informed Approach to the Tense System in the Greek of the New Testament
In this paper I summarise the findings presented in my recent PhD thesis in which I include some 80+ linguistic theories from Plato to Usage-based linguistics in order to enquire into the potential of linguistic theories in the study of aspect and tense in Ancient and particularly New Testament Greek. I discuss the challenge of working with several linguistic theories at the same time, the formati