Filetype
Purpose of review: Methylmercury (MeHg) is neurotoxic at high levels and particularly affects the developing brain. One proposed mechanism of MeHg neurotoxicity is alteration of the epigenetic programming. In this review, we summarise the experimental and epidemiological literature on MeHg-associated epigenetic changes. Recent findings: Experimental and epidemiological studies have identified chan
Continuous use of cloud computing and cloud sourcing has received limited research attention compared to cloud adoption. There are indications that cloud sourcing benefits are not easy to reap in continuous use for companies, calling for more research on the continuance use of cloud computing. The current study is one of the first studies of the continuance use of cloud computing processes at the
As part of the development of the beam imaging system at the European Spallation Source, luminescent screens have been fabricated by the flame spraying of scintillating materials onto stainless steel backings. A total of seven screens were produced, three of chromia alumina (Al2O3:Cr), two of YAG (Y3Al5O12:Ce) and two of a 50/50 mix of these. The properties of these screens under proton irradiatio
Edge-sealing, which involves treating the edges of wood products, improves water resistance. This study investigated the feasibility of edge-sealed cross-laminated timber (CLT) panels to reduce capillary water uptake, thereby resisting mould formation. The water and vapour permeabilities of ten characteristically different single-layer sealant coating systems were systematically determined. X-ray
I contribute to an emerging politics of loss through an empirical analysis of temporalities of climate change loss and damage in Australia. How people temporalize climate change informs their conception of causality, designation of losses and damages, and political response. By drawing attention to the diversity of onto-epistemological understandings and characterizations of climate change loss an
Research on climate change impact focuses on biophysical and economic dimensions. This paper seeks to unveil the association between smallholder farmers' food insecurity experience (FIE) during climate shock periods and their subsequent aspiration level. To this end, our analysis relied on data collected in rural Ethiopia following an unprecedented climate shock the country faced in 2016. We measu
Purpose of review: In comatose cardiac arrest survivors, the electroencephalogram (EEG) is the most widely used test to assess the severity of hypoxic-ischemic brain injury (HIBI) and guide antiseizure treatment. However, a wide variety of EEG patterns are described in literature. Moreover, the value of postarrest seizure treatment is uncertain. Absent N20 waves of short-latency somatosensory-evok
A stochastic hierarchical model for the evolution of low grade gliomas is proposed. Starting with the description of cell motion using a piecewise diffusion Markov process (PDifMP) at the cellular level, we derive an equation for the density of the transition probability of this Markov process based on the generalised Fokker–Planck equation. Then, a macroscopic model is derived via parabolic limit
Background: Grade of non–muscle-invasive bladder cancer (NMIBC) is an important prognostic factor for progression. Currently, two World Health Organization (WHO) classification systems (WHO1973, categories: grade 1–3, and WHO2004 categories: papillary urothelial neoplasm of low malignant potential [PUNLMP], low-grade [LG], high-grade [HG] carcinoma) are used. Objective: To ask the European Associa
Objective: Diagnosis of ventriculostomy related infections (VRI) in the neuro-intensive care unit remains challenging and current biomarkers lack adequate precision. The aim of this study was to explore the potential of Heparin-binding protein (HBP) in cerebrospinal fluid (CSF) as a diagnostic biomarker of VRI. Methods: All patients treated with an external ventricular drain (EVD) between January
The occurrence of coprostanol in soil, surface, and groundwater has recently been reported in several studies. Coprostanol indicates the presence of feces from mammals. For this reason, it is important to establish adsorption behavior in different kinds of geologic media. To our knowledge, we present for the first-time adsorption behavior of coprostanol in soil, sediment, and sand and an estimatio
Background: Clonal hematopoiesis of indeterminate potential (CHIP)—the age-related clonal expansion of blood stem cells with leukemia-associated mutations—is a novel cardiovascular risk factor. Whether CHIP remains prognostic in individuals with established atherosclerotic cardiovascular disease (ASCVD) is less clear. Objectives: This study tested whether CHIP predicts adverse outcomes in individu
In our meta-study from 2022, “A Literature Review and Meta-Analysis of the Effects of Lockdowns on COVID-19 Mortality – II,” we find that the effect of lockdowns—also referred to as ‘Covid restrictions,’ ‘social distancing measures,’ etc.—on mortality was negligible. The first version of our meta-study received criticism from Banholzer, et al. (2022). The authors raised “concerns regarding the sub
Recent years have seen profound challenges to democracy, including grave populist and autocratic shifts. In the Opinion, the EGE examines how certain configurations of digital technologies can contribute to a weakening of democratic institutions, even if they may not be its sole cause. Among these are the spread of harmful information, an unduly narrow understanding of privacy, algorithmic surveil
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a transmembrane proteoglycan, is highly expressed in intestinal subtype gastric tumors and that this signature associates with patient poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer cell motility and in
The efficiency with which flying animals convert metabolic power to mechanical power dictates an individual's flight behaviour and energy requirements. Despite the significance of this parameter, we lack empirical data on conversion efficiency for most species as in vivo measurements are notoriously difficult to obtain. Furthermore, conversion efficiency is often assumed to be constant across flig
