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A particularly well-studied evolutionary model is the vinegar fly Drosophila melanogaster, a cosmopolitan insect of ancestral southern-central African origin. Recent work suggests that it expanded out of Africa ∼9,000 years ago, and spread from the Middle East into Europe ∼1,800 years ago. During its global expansion, this human commensal adapted to novel climate zones and habitats. Despite much w
The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1667922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model
Care for older persons is a universal issue, but around 1900, new groups of wage-earners created a need for an age of retirement, forming a new era of institutional care. These old people’s homes were often charitable trusts, which required them to be seen as respectable to attract funding. Residents therefore faced a two-way contract: being offered dignified housing if they met societal standards
Following the adoption of the 2030 Agenda for Sustainable Development, multi-stakeholder partnerships (MSPs) have received renewed political attention. In several policy fields, MSPs have been criticized for a lack of accountability, resulting in efforts to redress this problem. However, it is still unclear how accountability challenges and shortcomings differ across partnerships operating within
BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved BackgroundThe clinical standard practice of [177Lu]Lu-PSMA-617 therapy is a single injection per treatment cycle, with 6 weeks between cycles. While clinical schedules currently utilize single-bolus cycles, splitting a treatment cycle into multiple smaller injections has demonstrated benefits in other radionuclide therapies, preclinically and in clinical studies. Potential mechanisms for improved
In this book, Anil Seth advocates a predictive processing approach to the understanding of conscious experience, which he claims would amount to something like a Copernican revolution. In three separate parts of the book, Seth discusses conscious level, conscious content, and conscious self. Among the strengths of the book is an ambition to stay close to the rich phenomenology of conscious experieIn this book, Anil Seth advocates a predictive processing approach to the understanding of conscious experience, which he claims would amount to something like a Copernican revolution. In three separate parts of the book, Seth discusses conscious level, conscious content, and conscious self. Among the strengths of the book is an ambition to stay close to the rich phenomenology of conscious experie
This book is an introduction to the Free Energy Principle (FEP) and Active Inference. The FEP has been described as new paradigm with potential to unify the biological and cognitive sciences. According to the FEP, living organisms persist by minimizing their free energy (which can be variously translated as uncertainty, surprise, prediction error, or discrepancies between model and world). Active This book is an introduction to the Free Energy Principle (FEP) and Active Inference. The FEP has been described as new paradigm with potential to unify the biological and cognitive sciences. According to the FEP, living organisms persist by minimizing their free energy (which can be variously translated as uncertainty, surprise, prediction error, or discrepancies between model and world). Active
In The Four Realms of Existence: A New Theory of Being Human, Joseph LeDoux (2023) argues for a conceptualization of being human in terms of four hierarchically integrated realms of existence: biological, neurobiological, cognitive, and conscious. Although LeDoux’s perspective is thought-provoking, it also raises several questions. One question is how to differentiate the conscious realm from the In The Four Realms of Existence: A New Theory of Being Human, Joseph LeDoux (2023) argues for a conceptualization of being human in terms of four hierarchically integrated realms of existence: biological, neurobiological, cognitive, and conscious. Although LeDoux’s perspective is thought-provoking, it also raises several questions. One question is how to differentiate the conscious realm from the
Objectives: To examine powered mobility learning in children with spinal muscular atrophy (SMA) type I, involving families and evaluating goal attainment through the use of small, modified electric toy cars in the children’s natural environments. Design: Single-blind pilot intervention study derived from an originally planned wait-list randomized controlled trial. This report includes only the imm
Negative symptoms (avolition, anhedonia, asociality, blunted affect, and alogia) are among the most disabling features of schizophrenia spectrum disorders. In the absence of treatment consensus guidelines, this PRISMA-compliant meta-analysis (PROSPERO: CRD42024613967) evaluated efficacy and clinical significance of interventions targeting this dimension. Web of Science/PsycInfo databases were sear
AbstractBackgroundThe role of nutrient intake in celiac disease pathogenesis is poorly understood.ObjectiveTo examine whether longitudinal childhood intake of selected vitamins and minerals is associated with celiac disease autoimmunity (CDA, primary outcome) and celiac disease (secondary outcome) in genetically at-risk children.MethodsA total of 6,520 HLA-conferred at-risk children in the observa
Strejker och arbetsplatskonflikter som löper över flera år är ovanliga i Sverige. Lockouten av syndikalistiska skogsarbetare i Lossmen-Ekträskpågick mellan 1924 och 1931. Ingen arbetsplatskonflikt har, ossveterligen, pågått längre. Arbetarens Håkan Gustafsson och kulturgeografen Johan Pries har grävt ner sig i Arbetarens arkiv för att ta reda på: vad hände egentligen under de där dramatiska åren?
In this chapter, I reflect on the use of sociologist Erving Goffman’s dramaturgical metaphor to understand the victim-offender mediation process. Using metaphors can both open unexpected, valuable views, as well as be limiting. Having entered a specific metaphoric realm means that we are able to perceive particular aspects and perspectives (as crucial) but not others. One benefit of the dramaturgi
Under åren 1976 till 1982 devalverades den svenska kronan sammanlagt fem gånger, sista gången 1982 med hela 16 procent. Denna offensiva devalvering var den första åtgärd som den nya socialdemokratiska regeringen vidtog efter valsegern 1982. Superdevalveringen var ett spännande ekonomiskt och politiskt experiment som knappast har någon tidigare motsvarighet i vår växelkurspolitiska historia. Den på
Inflation is not merely a shift in the value of money, it is also involving a redistribution of value. While some groups are severely affected by inflation, others profit from it. So, who bears the costs of inflation: corporations, employees, or consumers? And how is this redistribution taking place, by which devices? This study takes a critical look at a central device used in various markets: th
BACKGROUND: Caries and periodontitis are amongst the most prevalent diseases worldwide, leading to pain and loss of oral function for those affected. Prevention relies heavily on mechanical removal of dental plaque biofilms but for populations where this is not achievable, alternative plaque control methods are required. With concerns over undesirable side-effects and potential bacterial resistanc
In nature, bacteria usually exist as mixed-species biofilms, where they engage in a range of synergistic and antagonistic interactions that increase their resistance to environmental challenges. Biofilms are a major cause of persistent infections, and dispersal from initial foci can cause new infections at distal sites thus warranting further investigation. Studies of development and spatial inter
