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Low barriers to trade and access to international capital markets have long been argued to improve economic conditions in a country. However, there is less consensus on the impact of economic globalization on the distribution of those gains across society. There are several possible explanations for the conflicting findings in the existing literature, perhaps most notably endogeneity issues that p
Objective Type I interferons (IFN) drive systemic lupus erythematosus (SLE) pathogenesis. Some patients develop neutralizing IFN autoantibodies (anti-IFN ab), which theoretically could modify disease activity. We aimed to determine the prevalence of anti-IFN ab in patients with SLE, identify the age and when during the disease course of anti-IFN ab emerge, and assess their association with organ d
Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th
Finding the optimal subset of individuals to observe in order to obtain the best estimate of the average opinion of a society is a crucial problem in a wide range of applications, including policy-making, strategic business decisions, and the analysis of sociological trends. We consider the opinion vector X to be updated according to a DeGroot opinion dynamical model with stubborn agents, subject
Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB
Rapid warming in the Arctic is transforming northern ecosystems and altering their role in the global carbon cycle. Rising temperatures are driving shifts in vegetation composition, phenology, and ecosystem functioning, including earlier growing seasons and the expansion of shrubs across tundra landscapes. These changes influence surface energy balance, carbon uptake, and climate feedbacks, yet su
In 2024, the European Academy of Paediatrics (EAP) published a list of 10 low-value practices in paediatric care. Embedded in the Choosing Wisely framework, this list is a step towards promoting targeted and evidence-based care. However, no single recommendation can change prescription habits and we need to acknowledge that overuse of the available resources has multiple causes. Among them, the ph
Sammanfattning Kapitel 2 Presentation av ett nytt tumör-behandlingskoncept med ”Pre-kirurgisk intermittent ultrahypofraktionerad strålbehandling” (PSiRT) ”kombinerad med immunterapi” (PSiRIT), särskilt immun¬kontrollpunktshämmare (anti-CTLA4 och anti-PD-1).Intermittent ultrahypofraktionerad strålbehandling innebär:• Optimal absorberad dos 6–8 Gy per fraktion • Doser >10 Gy kan öka immunosuppress
This chapter highlights the centrality of atmospheres in tightly controlled environments like courtrooms and youth detention homes. In courtrooms, social control is achieved through affective arrangements, such as reading emotional cues and using touch or its avoidance to manage order. Legal professionals rely on their ability to sense and act on shifting atmospheres as part of their implicit skil
Critical events frequently occur in hospital settings. Cinematic portrayals of medicine and medical environments can illuminate historical developments and perspectives on healthcare, medical professions, and specialisations. This article aimed to explore the interplay between structural framework, professional, and relational factors when facing critical events and their management in a hospital
BackgroundTo educate students and prepare them for life in society, school principals, teachers, and staff need proper work-related organizational preconditions, motivation, and good health. In this context, span of control (SoC, i.e., the number of employees a manager is accountable for) is an understudied modifiable organizational precondition that influences the relationships between managers a
Streptococcus pneumoniae resists host defenses through multiple surface factors, yet their specific contribution to protection against antimicrobial peptides remains incompletely understood. We examined the role of pneumococcal surface protein A (PspA) and the polysaccharide capsule in protection against the human defensin HNP-1. PspA conferred increased resistance to HNP-1-induced killing, show
Background: Helicobacter pylori (Hp) and its virulence factor Cytotoxin-associated gene A (CagA) have been linked to myocardial infarction (MI), but the mechanisms are unknown. This study aims to test if Hp infection and CagA are associated with pre-specified inflammatory and vascular biomarkers in patients with MI and to explore whether a broader biomarker panel can predict infection. Furthermore
This study investigated the retention of spatial knowledge in buildings following route-learning training in a virtual reality environment. A total of 121 participants were tested up to three months later on putting waypoints of the route in the correct order and recalling directions at waypoints. Memory accuracy declined over time, consistent with classic memory theory. Route knowledge was retain
