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Precise patient positioning and daily anatomical verification are crucial in external beam radiotherapy to ensure accurate dose delivery and minimize harm to healthy tissues. However, Current image-guided radiotherapy techniques struggle to balance high-quality volumetric anatomical visualization and rapid low-dose imaging. Addressing this, reconstructing volumetric images from ultra-sparse X-ray

To date, the use of CRISPR/Cas9 technology in ecological-model species for validating genotype to phenotype connections has focused primarily on visual phenotypes using G0 mutations, coupled with analyses of resulting mosaic phenotypes. However, studies of physiological phenotypes necessitate germline mutations in order to assess non-visible phenotypic effects, and thus, dedicated efforts to devel

Quantifying solute transport across epithelial cell layers grown on transwell inserts is a common approach in early-stage drug development to estimate pharmacokinetic properties such as absorption and bioavailability. To increase throughput and reduce variability, these assays are increasingly automated, including the use of robotic or microfluidic systems for time-resolved sampling. However, both

Ethylene carbonate (EC) is the archetype solvent in Li-ion batteries. Still, questions remain regarding the numerous possible reaction pathways of EC. Although the reaction pathway involving direct EC reduction and SEI formation is most commonly discussed, EC ring-opening is often observed, but seldomly addressed, especially with respect to SEI formation. By applying Online Electrochemical Mass Sp

Although the two active redox centers in Li-rich cathodes, including the anionic and cationic contributions, can enable Li-ion batteries to achieve outstanding specific energy, their behaviors at different current densities have not been clarified. Here, we provide a comparative study of transition metals (TMs) and oxygen redox activities by directly accessing their oxidation states in Li-rich mat

Aqueous rechargeable batteries are appealing alternatives for large-scale energy storage. Reversible cycling of high-energy aqueous batteries has been showcased using highly concentrated aqueous electrolytes, which lead to a significantly suppressed water activity and formation of a stable solid-electrolyte interphase (SEI). However, the high salt concentration inevitably raises the cost and compr

This study explores the integration of Large Language Model (LLM) and Information Retrieval (IR) components to enable filtered search over multimodal structured data. We identify core integration challenges and introduce a conceptual framework based on two paradigms: filtered retrieval and filtered re-ranking. With the focus on the latter, we employ RT-3 rank transformation to dynamically adjust t

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2

Rationale: Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and prevent complications. Midazolam is a short-acting benzodiazepine that is used in neonatal intensive care units. This is an update of a Cochrane review first published in 2003. Objectives: To assess the benefits and harms of midazolam – compared with placebo, other pharmacological interventions, and n

Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which is not readily available clinically. Targeted exon panels are used for clinical cfDNA variant calling. In this report, we conduct an investigation of multiple published fragmentomics methods for WGS, b

Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researc

Thyroid hormone (TH) signaling plays a major role in the development, energy homeostasis, and metabolism of most tissues. Recent studies have identified THs as drivers of prostate cancer (PCa) development and progression. We reported that the T3-scavenger protein µ-crystallin (CRYM) regulates the development and progression of PCa and that this involved crosstalk with androgen receptor (AR) signal

This editorial introduces the special feature’s main objective: to provide latest research findings on the dynamics between environmental protection and post-conflict peacebuilding processes after internal armed conflicts. In the feature, we propose a broad understanding of environmental peacebuilding that takes all cycles of the peacebuilding process into account and puts stronger emphasis on the

Seizure-related homolog protein 6 (SEZ6) is a cell surface type 1 transmembrane protein involved in neuronal development, the expression of which in adult tissues is almost exclusively limited to the central nervous system. Aberrant expression of SEZ6 has been associated with neurodevelopmental and psychiatric disorders including epilepsy, schizophrenia, and Alzheimer disease. More recently, SEZ6

In contemporary Sri Lanka, nationalistic Sinhala organizations like Bodu Bala Sena (BBS) have made a great impact on the debate over what role Buddhism should play in the country. BBS claims that Islam is a non-Sri Lankan element in the Buddhist majority society, campaigning on such issues on social media between 2012 and 2014. This led Sri Lankan Muslim organizations to use social media to counte

De senaste decennierna har inneburit stora omvälvningar av den svenska offentligheten. Internets genomslag, de sociala medierna och smarta telefoner har i grunden förändrat hur vi tar till oss information om aktuella händelser och kunskap om det förflutna. Traditionell läsning har haft svårt att konkurrera med audiovisuella medier i den nya uppmärksamhetsekonomin. Vilka roller historiker ska ha oc

Recent progress in “water-in-salt” electrolytes (WiSEs) and “hybrid aqueous/non-aqueous electrolytes (HANEs)” made broader choices of active material in aqueous Li-ion batteries (ALIBs), because of their compared to standard aqueous electrolytes expanded electrochemical stability windows (ESWs). Exploring high energy density ALIBs is a consequently meaningful research topic. However, the formation

Rechargeable aqueous zinc batteries (AZBs) have been recognized as attractive energy storage devices because of their intrinsic superiorities, e. g., high safety, low material cost and environmental benignity. However, challenges such as dendrite formation on the surface of zinc (Zn) anode, poor reversibility of Zn plating/stripping and short circuit of the cell, having detrimental impact on cycle