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After DNA replication, chromosomal processes including DNA repair and transcription take place in the context of sister chromatids. While cell cycle regulation can guide these processes globally, mechanisms to distinguish pre- and post-replicative states locally remain unknown. Here we reveal that new histones incorporated during DNA replication provide a signature of postreplicative chromatin, re
Användningen av artificiell intelligens ökar inom många områden i det samtida samhället, inklusive datorsynssystem som bygger på maskininlärning och artificiella neuronnätverk. Dessa system omformar handlingsmöjligheter och beskrivs ofta som ”svarta lådor” som utmanar etablerade former av vetenskaplig förståelse och teknisk kontroll. Det är därför viktigt att förstå de aktiviteter genom vilka sådaThe uses of artificial intelligence are increasing across many areas of contemporary society, including computer vision systems involving machine learning and artificial neural networks. These systems rearrange action possibilities and are often described as “black boxes” that challenge conventional modes of scientific understanding and engineering control. It is important to understand the activi
Small bodies exist in distinct populations within their planetary systems. These reservoir populations hold a range of compositions, which to first order are dependent on formation location relative to their star. We provide a general overview of the nature of the reservoirs that source exocomets, from the influence of the stellar environment through planetesimal formation to comparisons with Sola
Malaria remains a great public health concern, with an estimated 263 million cases and 597,000 estimated deaths in 2023. Artemisinin-based combination therapies (ACTs) are currently the first-line treatment for uncomplicated P. falciparum malaria in Sub-Saharan Africa (SSA), but the emergence of resistant parasites is threatening their efficacy. Single-nucleotide polymorphisms (SNPs) in the pfk13
Parkinson’s disease (PD) is a progressive neurodegenerative disease, characterized by degeneration of dopaminergic neurons, leading to notable difficulties with one’s movement. Among different treatment options, stem cell replacement therapies have been recognized as an option to not only treat disease symptoms but to address its underlying cause- neuronal degeneration. This can be achieved throug
Kan kreatinmetabolismen vara ett potentiellt behandlingsmål för lungcancer i skivepitel? Lungcancer är en av världens vanligaste typer av cancer. Varje år rapporteras över 2 miljoner nya lungcancer fall och 1,8 miljoner dödsfall i världen enligt statistik från 2022. Cancer uppstår som en konsekvens av både arv och miljö. Den vanligaste orsaken till lungcancer är rökning. De två vanligaste typerLung cancer is one of the most common cancer types and the leading cause of cancer-related mortality. Squamous cell carcinoma (SqCC) of the lung is the second most common histological subtype of lung cancer and the most prevalent in smokers. It is aggressive and hard to treat due to a lack of identified driver mutations and unresponsiveness to treatment. Finding new targeted therapies for SqCC is
Background Venture Creation Programs (VCPs) provide a unique experiential learning setting in which real-world uncertainty, emotional dynamics, and iterative learning cycles shape entrepreneurial decision-making. Research Gap While prior research has established the importance of effectuation and causation in entrepreneurship, less is known about the factors influencing students’ use of these log
The call is coming from inside: your body’s own defences might be against you Mycobacterium avium is a species of bacteria, closely related to tuberculosis, that can cause pulmonary disease in people. Despite this, we likely come in contact with these microorganisms every day. They can be found in water reservoirs and in the soil, entering the lungs of the host – like humans and rodents – through
Why studying proteins is important All our cells contain hereditary information, DNA, that allows the building blocks of our body, the cells, to know how to behave. However, the DNA is only the instruction book while proteins are the key players doing all the important work. We have to cope with many situations throughout our lives, such as stress, hunger and sickness among various others, and it
Saccharomyces cerevisiae: Genome editing and investigation of the peroxisome & beta-oxidation For thousands of years humans have used yeast to brew beer, bake bread and make wine. Nowadays, these microorganisms can be used to produce various chemicals and proteins. One interesting compound is capsaicin, found in the chili pepper plant and commonly used in food, but lesser-known for its applic
This article explores the complex relationship between performance programs in higher music education and the evolving demands of current and future professional music scenes. Drawing upon career anchor theory and enactive cognitive science, it introduces a workshop-based framework to support students in reflecting on future working life. The framework decenters ideas of entrepreneurship and marke
Aim: In uncertain clinical situations, such as assessing the risk of exacerbation of apical periodontitis in root- filled teeth, un-dergraduate students can benefit from being trained to reflect. This study aimed to explore how students specifically reflectedon clinical experiences in relation to uncertainty when assessing a case involving a root- filled tooth with apical periodontitis.Methodolo
BACKGROUND: Catheterization of the vein is frequently a painful procedure. Assessing venous cannulation induced pain (VCP) before surgery have been used to predict the intensity of postoperative pain and postoperative opioid consumption. The aim of this study was to investigate the intra-individual variation in venous cannulation induced pain at three consecutive time points and factors influencin
Introduction: Qualitative assessment of hypoxic ischaemic encephalopathy on computed tomography (CT) after cardiac arrest is limited by interrater agreement. We explored how qualitative assessment can be improved. Methods: In-depth analysis of radiological items evaluated in a prospective sub-study within the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (T
The model is based on an existing framework for high-cycle fatigue by Ottosen et al. (2008) that treats the fatigue damage as a time-continuous variable, opposed to relying on cycle-counting techniques. We propose a generalized formulation where the relationship between the fatigue limits for fully reversed shear stress and normal stress can take any value, unlike in the original formulation, wher
To secure sufficient, clean, and reliable drinking water amidst climate change, evolving land use, and population growth, artificial infiltration ponds are essential tools for drinking water providers in many areas. Optimizing their operation requires a detailed understanding of infiltration processes and subsurface water transport dynamics.At a Managed Aquifer Recharge (MAR) facility in southern
Epilepsy affects a significant portion of people worldwide and still requires alternative treatments due to resistance to anti-seizure medications. Gene therapy offers a promising alternative with several targets already established. Of these, glial cell line-derived neurotrophic factor (GDNF) and its receptor GFR⍺1 are well recognised for their roles in enhancing inhibitory signalling and support
ADAR1 as a Therapeutic Target in Prostate Cancer Prostate cancer is the second most common cancer and a leading cause of cancer-related deaths in men. While early-stage prostate cancer can be managed effectively, once it spreads, treatment options are limited and usually not curative. Immunotherapy, which boosts the immune system to fight cancer, has been effective in some cancer types but not in
Can Lin28b treat childhood leukemia? B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is one of the more common types of cancer in children. This disease originates mainly from progenitors of a white blood cell type known as the B-cell. Mature B-cells are mainly known for helping us clear infections by producing pathogen-binding antibodies. Because BCP-ALL cancer cells stem from B-cell pre
