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Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i

Background: Dementia is a growing public health concern, and although diet is a modifiable potential risk factor, the role of free sugar intake remains unclear. Excess sugar has been linked to metabolic and cardiovascular dysfunction, both associated with cognitive decline, but evidence regarding specific sugar sources is limited. Objectives: This study aimed to investigate the associations betwee

Background and aims: We examined whether the excess cardiovascular disease (CVD) risk among adults with steatotic liver disease (SLD) subtypes could be reduced or eliminated through joint control of low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) [Lp(a)], and high-sensitivity C-reactive protein (hs-CRP). Methods and results: This prospective cohort study included 291,995 participants f

This contribution to the conference on Transitioning away from Fossil Fuels focuses on thematic pillar 3 which addresses the advancement of international cooperation and climate diplomacy. The Fossil Fuel Treaty Initiative represents an opportunity to align climate ambition with human rights and biodiversity stewardship. We consider this stage of the process a crucial waypoint for responding in a

Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale compa

Esta contribución a la Primera Conferencia Internacional sobre la Transición hacia la no proliferación de Combustibles Fósiles se centra en el pilar temático 3, relativo al avance de la cooperación internacional y la diplomacia climática. La Iniciativa del Tratado de No Proliferación de Combustibles Fósiles (en adelante, Iniciativa FFNPT, por sus siglas en inglés) representa una oportunidad para a

Purpose: To investigate factors guiding follow-up imaging after hospital discharge in atraumatic intracerebral hemorrhage (ICH) across large European academic centers and compare decision-making patterns using a standardized approach. Methods: Expert neuroradiologists from nine European centers in eight countries detailed their follow-up algorithms for deep and lobar ICH, specifying (1) patient-re

Fourth-generation synchrotron light sources deliver flux densities up to two orders of magnitude higher than previous generations, enabling X-ray imaging at unprecedented spatiotemporal resolution. This is attractive for non-destructive 4D (3D + time) studies of fast dynamics under in-situ or operando conditions. State-of-the-art 4D X-ray imaging at large-scale facilities relies on tomography and