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Genome-wide association studies (GWAS) have revealed extensive polygenic signals and overlapping genetic architectures across human traits, creating a need for resources that connect trait-level genetic relationships with gene-level functional evidence. Here, we developed the Multi-Omics Causal Resource Database (MOCR-DB), an interactive platform that integrates large-scale GWAS summary statistics
We explore three examples of teaching-development activities that aim to promote discussions about teaching among academic staff across several Norwegian Earth System Science departments. The three events are a conference-like annual gathering of students and staff from across the country, a monthly Teaching and Learning themed Journal Club held at a large department with a wide range of research
Preclinical gene therapy studies of mitochondrial diseases remain limited due to the typically multi-organ manifestations and the scarcity of physiologically relevant animal models. Mutations in BCS1L , a nuclear gene encoding an assembly factor for mitochondrial complex III (CIII), are the most common cause of CIII deficiency. The most severe phenotype, GRACILE syndrome, is caused by a homozygous
Lymphomas are broadly categorized into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Despite treatment advances, they remain a major cause of cancer-related morbidity and mortality in Canada. This study examined temporal trends in socioeconomic inequalities in lymphoma mortality in Canada from 2000 to 2019. Using a unique census division level dataset (n = 280) constructed by pooling infor
Advances in ceramic additive manufacturing have enabled fabrication of piezoelectric metamaterials in which architecture can be used as a design parameter to expand and independently tune the different anisotropic electromechanical coupling modes. A critical step toward rational design of architected piezoceramics is the determination of complete piezoelectric tensor matrices for the differently o
Strongly interacting fermions represent the key constituent of several intriguing phases of matter. However, due to the inherent complexity of these systems, important regimes are still inaccessible. Here, we derive a realistic and flexible setup based on ultracold magnetic lanthanide atoms trapped in a one-dimensional optical lattice. Leveraging their large magnetic moments, we design a fermionic
Background. Ultra-High Dose Rate Radiotherapy (UHDR-RT) is an emerging cancer treatment that delivers radiation at dose rates exceeding 40 Gy/s. While UHDR-RT offers potential therapeutic benefits, accurate dosimetry presents significant challenges. Ionisation chambers, the standard for clinical dosimetry as reference and monitor dosimeters, experience significant ion recombination at high dose ra
Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non-amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large-scale clinical trials, which typically focus on late-onset, sporadic amnestic-predominant AD. Consequently, treatment options and research ef
Avocado farmworkers are potentially exposed to multiple pesticides, which may influence hematological parameters and detoxification enzyme activities. This study enrolled 105 avocado farmworkers from Michoacán, Mexico, during May–August 2021. We quantified 12 pesticide metabolites in urine samples collected at two visits (12–13 weeks apart) and estimated annual exposure intensity scores (EIS) usin
mer-[CrCl3(THF)3] is a useful and labile precursor for Cr(III) organometallic chemistry, but the commercial material is costly and sometimes poorly defined, whereas existing synthetic routes to the complex rely on corrosive reagents, prolonged reaction times, or elaborate experimental setups which are impractical for glovebox work. Herein we present a facile, mild, and glovebox-friendly synthesis
Background: Identification of breast cancer patients at high risk of relapse after neoadjuvant chemotherapy (NAC) is of high unmet clinical need. The multicenter ALIENOR study aimed to identify patients with molecular residual disease (MRD) using an ultrasensitive ctDNA assay during follow-up after NAC. Patients and methods: Patients whose tumor did not achieve pathologically documented complete r
Importance: Identifying individuals at higher risk of pancreatic cancer (PC) is critical for developing targeted prevention strategies. Objective: To investigate whether the potential association of modifiable risk factors with PC varies across genetic risk profiles and age. Design, Setting, and Participants: This prospective population-based cohort study used data from participants in the UK Biob
The capacity to adapt to surprising conditions by quickly changing existing ways of working is essential for organizations operating in complex and unpredictable environments. Yet empirical understanding of factors contributing to adaptive capacity remains limited and fragmented. This paper presents findings from a qualitative case study of a sudden internal flooding at a Swedish hospital, based o
Chronic pancreatitis is a progressive inflammatory disease associated with substantial nutritional and metabolic consequences. Beyond classical malnutrition, patients frequently develop alterations in body composition, particularly sarcopenia, which are increasingly recognised as clinically relevant but remain inconsistently assessed. The reported prevalence of sarcopenia ranges from 20% to 70%, i
Background: Critical illness myopathy is a common and devastating consequence of critical care, causing dramatic loss of muscle mass and function in intensive care unit patients. Functional deficits often exceed the loss in muscle mass and myosin content. However, the mechanisms underlying the loss of force and emergence of myosin-expressing non-force-generating fibers remain elusive. Methods: Myo
We model the flow behaviour of dense melts of flexible and semiflexible ring polymers in the presence of walls using a hybrid multiscale approach. Specifically, we perform molecular dynamics simulations and apply the Irving–Kirkwood formula to determine an averaged stress tensor for a macroscopic model. For the latter, we choose a Cahn–Hilliard–Navier–Stokes system with dynamic and no-slip boundar
Floods are considered the most frequent type of natural disaster, causing immense damage to human life, infrastructure, and the economy globally. Due to climate change and urbanization, the negative impacts of pluvial flooding in particular are expected to increase in the future. To reduce these impacts and support risk management and adaptation, comprehensive flood risk assessments are required t
Studien undersöker hur surfkultur används och representeras i platsmarknadsföringen av Varberg i relation till den ökade användningen av lokala kulturer inom platsmarknadsföring. Studiens syfte är att undersöka hur surfkultur omvandlas från en lokal praktik till en strategisk resurs, samt hur omvandlingen påverkar hur destinationen framställs och uppfattas. En kvalitativ fallstudie har genomförts
This study examined how social workers in Swedish social services described their work with communicative accessibility for children with communication difficulties or children who do not use verbal communication. The study also examined the professional and organizational conditions that affected this work and the consequences that limited communicative accessibility could have for children's
