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Researchers from Lund University have now succeeded in restoring mobility and sensation in rats that have suffered Stroke, by transplanting neurons developed from reprogrammed human skin cells into animal brains. “Six months after transplant, we could see how the new cells had repaired the damage that a stroke had caused in the brains of rats," explains Professor Zaal Kokaia, who together with sen

https://www.stemcellcenter.lu.se/article/scientists-repair-stroke-damaged-rat-brain-1 - 2025-12-20

With a research focus on the development and application of in vitro models to study human brain evolution and disease, PhD student Daniela Grassi will be defending her thesis on Thursday 23rd of April 2020. Here, Daniela tells us about her research in the Molecular Neurogenetics group, led by Johan Jakobsson, and her time spent at Lund Stem Cell Center. Can you tell us about your research?During

https://www.stemcellcenter.lu.se/article/thesis-defence-interview-daniela-grassi - 2025-12-20

Carla Azevedo is set to defend her PhD thesis titled “Oligodendroglial (dys)function in alpha-synucleinopathies” on Thursday 30th of April. Here, Carla answers a few questions about her PhD journey at Lund Stem Cell Center, researching in the iPSC Laboratory for CNS disease modeling. How did you end up doing a PhD at Lund Stem Cell Center?I’m originally from Porto, Portugal. After my undergraduate

https://www.stemcellcenter.lu.se/article/thesis-defence-interview-carla-azevedo - 2025-12-20

Huntington disease is fatal inherited brain disorder, usually emerging during mid-life. Although there is currently no known cure, the Molecular Neurogenetics group at Lund Stem Cell Center aims to understand the defective cellular processes leading to the progression of this disease. Characterised by symptoms including impaired motor and cognitive function, Huntington disease is caused by the exp

https://www.stemcellcenter.lu.se/article/autophagy-and-treatment-huntington-disease-timing-key - 2025-12-20

Stem cell researchers at Lund University in Sweden have developed a new research model of the early embryonic brain. The aim of the model is to study the very earliest stages of brain to understand how different regions in the brain are formed during embryonic development. With this new insight, researchers hope to be able to produce different types of neural cells for the treatment of neurologica

https://www.stemcellcenter.lu.se/article/new-method-provides-unique-insight-development-human-brain - 2025-12-20

Neurogenesis, the process by which new neurons are formed, dramatically declines in the aging brain. A research group from Lund Stem Cell Center have published a study that sheds light on the different factors contributing to this loss, particularly the role of inflammation. “One of the focuses of our research is on what goes wrong in the brain during aging” explains Henrik Ahlenius, principle inv

https://www.stemcellcenter.lu.se/article/researchers-identify-novel-regulator-neurogenesis-aged-brain - 2025-12-20

PhD student Franziska Olm has been developing a microfluidic-based acoustophoresis method to process stem cell preparations label-free, a technique with great research and clinical potential. In this interview, Franziska tells us about her PhD project, her time at Lund Stem Cell Center and her plans following her thesis defence on Friday June 12th 2020. Can you tell us about your research?Complex

https://www.stemcellcenter.lu.se/article/thesis-defence-interview-franziska-olm - 2025-12-20

Researchers from Lund Stem Cell Center have identified a novel target for the expansion of human blood stem cells ex vivo and shed light on the mechanism of action of a stem cell promoting molecule, currently in phase II clinical trials. Hematopoietic stem cell transplantation is a curative therapy for many patients suffering from life threatening blood disorders. This treatment is currently limit

https://www.stemcellcenter.lu.se/article/new-insights-ex-vivo-expansion-transplantable-human-blood-stem-cells - 2025-12-20

Researchers from Lund University have developed a promising new method for delivering biomolecules into human blood stem cells using nanotechnology. With little to no detrimental effects on target cells, this novel approach has great potential for research and clinical applications. The discovery and development of therapeutic biomolecules - such as the gene editing technology CRISPR - has rapidly

https://www.stemcellcenter.lu.se/article/nanostraws-used-deliver-biomolecules-stem-cells - 2025-12-20

Those who find themselves at Lund BMC can now discover exciting new artwork highlighting the visual side of research. Created by researchers from the Faculty of Medicine, these images were part of ‘The invisible body – art in science’ exhibition held in Stockholm. Here, Christine Karlsson - director of the Research School in Stem Cell Biology at Lund Stem Cell Centre - provides us with more inform

https://www.stemcellcenter.lu.se/article/striking-research-images-decorate-lund-biomedical-center - 2025-12-20

Prof. Johan Jakobsson has been appointed as coordinator and Assoc. Prof. Johan Flygare as deputy coordinator of StemTherapy and Lund Stem Cell Center.Together they will continue to manage StemTherapy and Lund Stem Cell Center towards scientific and educational excellence, whilst strengthening the direction of translational research. We would like to thanks Prof. Zaal Kokaia and Prof. Jonas Larsson

https://www.stemcellcenter.lu.se/article/new-leadership-lund-stem-cell-center - 2025-12-20

Neuroscientists and stem cell researchers at Lund University in Sweden have developed a research model that allows studying human hippocampal neurons, the brain cells primarily affected by Alzheimer’s disease pathology. The study has been published in Stem Cell Reports. In Alzheimer’s disease the hippocampus, a brain structure that regulates motivation, emotion, learning, and memory, is severely a

https://www.stemcellcenter.lu.se/article/new-research-paves-way-developing-therapies-could-slow-down-alzheimers - 2025-12-20

Congratulations to Lund Stem Cell Center PI and Wallenberg Fellow Paul Bourgine, who has been awarded European Research Council funding. His research group, the Laboratory for Cell, Tissue and Organ Engineering, are using engineered miniaturized human bone organs to better understand the mechanisms of blood formation and cancer development. In Europe, over 80 million people suffer from blood disor

https://www.stemcellcenter.lu.se/article/paul-bourgine-awarded-prestigious-european-research-council-grant - 2025-12-20

Prof. Johan Jakobsson and Assoc. Prof. Agnete Kirkeby from Lund Stem Cell Center and University of Copenhagen, along with co-applicants Prof. Roger Barker from Cambridge, UK and Assoc. Prof. Molly Hammell from Cold Spring Harbour Laboratory, US, have been awarded a prestigious grant from the Aligning Science Across Parkinson’s initiative. Using this funding they will investigate the role transposa

https://www.stemcellcenter.lu.se/article/researchers-investigate-role-transposable-elements-neuroinflammation-and-parkinsons-disease - 2025-12-20

Johan Richter's research has resulted in the successful development of gene therapy for the hereditary disease malignant infantile osteopetrosis. For the past few years, the research group has established a collaboration with an American biotech company and all the permits needed to start a clinical trial have now been obtained. Every year in Sweden a child is born with the unusual skeletal diseas

https://www.stemcellcenter.lu.se/article/successful-biotech-collaboration-brings-gene-therapy-project-clinic - 2025-12-20

PhD student Nicola Guzzi will be defending his thesis titled “Post-transcriptional control of stem and cancer cell fate - new roles for an old RNA modification” on Thursday 24th of September 2020. In this interview, Nicola tells us about his PhD journey within the RNA and Stem Cell Biology research group at Lund Stem Cell Center. What have you been working with during your PhD?During my PhD in the

https://www.stemcellcenter.lu.se/article/thesis-defence-interview-nicola-guzzi - 2025-12-20

Marcella Birtele will be defending her PhD thesis titled “Functional and Transcriptional Studies of Human Dopaminergic Neurons” on Friday 2nd October. Researching within the Developmental and Regenerative Neurobiology group led by Prof. Malin Parmar, here Marcella tells us about her PhD studies at Lund Stem Cell Center. What has been the research focus of your PhD?Although the projects that I have

https://www.stemcellcenter.lu.se/article/thesis-defence-interview-marcella-birtele - 2025-12-20

With two articles published in quick succession from his time as a research fellow at Cambridge University, UK, Christopher Douse has moved to Lund Stem Cell Center to develop a research programme on newly-discovered guardians of the human genome. More than half of the human genome consists of transposons, DNA sequences that can ‘jump’ around within the genome. Left unchecked these elements can ca

https://www.stemcellcenter.lu.se/article/hush-and-morc2-new-players-transposon-regulation-during-human-development - 2025-12-20

Every year the Swedish Society for Medical Research awards funding to promising young medical researchers. Grant recipients are funded for four years of full- or part-time research, with the aim of establishing an independent scientific career. At this year's call, 203 applications were assessed, of which eight were approved. Isaac Canals from Lund Stem Cell Center is one of this year's grant reci

https://www.stemcellcenter.lu.se/article/lund-stem-cell-center-researcher-awarded-ssmf-large-grant - 2025-12-20

In a collaborative study, researchers from Lund Stem Cell Center and University College London have developed a novel method of isolating ‘young’ stem cells still present in old mice. They show that activity of mitochondria, the power generators of the cell, is a stronger indicator of stem cell fitness than age and is a potential therapeutic target for the treatment of age associated disease. The

https://www.stemcellcenter.lu.se/article/novel-approach-identifies-young-stem-cells-old-mice - 2025-12-20