Optimister har bättre hälsa
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https://www.lupop.lu.se/article/optimister-har-battre-halsa - 2025-12-14
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Ny studie från Region Skåne: Återfall av Clostridium difficle
Vid verksamhetsområdet infektionssjukdomar på Skånes universitetssjukhus planeras en studie kring återfall av Clostridium difficile (nyligen namnbyte till Clodstridoides difficile). Studien ska utreda vilka faktorer som kan vara avgörande för att få fler återfall. Läs mer på https://www.lupop.lu.se/aterfall-av-clostridium-difficle
https://www.lupop.lu.se/article/ny-studie-fran-region-skane-aterfall-av-clostridium-difficle - 2025-12-14
The Causal Interpretation of “Overall Vaccine Effectiveness” in Test-Negative Studies
In this article we discuss the potential for a weighted average of age-specific VE estimates to provide a more meaningful measure of overall VE. Read the paper at https://academic.oup.com/aje/article/190/10/1993/6217345
https://www.lupop.lu.se/article/causal-interpretation-overall-vaccine-effectiveness-test-negative-studies - 2025-12-14
The Case Time Series Design
The case time series design represents a general and flexible tool, applicable in different epidemiologic areas for investigating transient associations with environmental factors, clinical conditions, or medications. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/The_Case_Time_Serie…
https://www.lupop.lu.se/article/case-time-series-design - 2025-12-14
Strength in causality: discerning causal mechanisms in the sufficient cause model
In this article, we discuss how to discern the causal mechanisms of interest in the sufficient cause model, which pays closer attention to the relationship between the sufficient cause model and the Bradford Hill viewpoints. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021-00798-6
https://www.lupop.lu.se/article/strength-causality-discerning-causal-mechanisms-sufficient-cause-model - 2025-12-14
On the use of nonparametric bounds for causal effects in null randomized trials
The Danish randomized trial studying the effect of mask recommendation (DANMASK-19) was widely discussed in the media. We aimed to analyze this trial from a causal inference perspective. Read the paper at https://academic.oup.com/aje/article/190/10/2231/6279406
https://www.lupop.lu.se/article/use-nonparametric-bounds-causal-effects-null-randomized-trials - 2025-12-14
Marginal Sufficient Component Cause Model - An Emerging Causal Model With Merits?
In this article, we illustrate that careful scrutiny based on the conventional sufficient cause model yields further insights into the concept of agonism in a more biologic sense. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/Marginal_Sufficient…
https://www.lupop.lu.se/article/marginal-sufficient-component-cause-model-emerging-causal-model-merits - 2025-12-14
Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease
In an extension of Mendelian randomization, we leveraged variation in genetic risk for late-onset AD risk to estimate the causal effect of AD on BMI and the earliest ages at which AD-related weight loss (or lower BMI as a proxy) occurs. Read the paper at https://academic.oup.com/aje/article/190/10/2163/6222073
https://www.lupop.lu.se/article/extension-mendelian-randomization-identify-earliest-manifestations-alzheimer-disease - 2025-12-14
Effect of Adjustment for Case Misclassification and Infection Date Uncertainty on Estimates of COVID-19 Effective Reproduction Number
Adjusting for epidemic curves based on surveillance data is necessary if estimates of missed cases and the effective reproduction number play a role in management of the COVID-19 pandemic. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/11000/Effect_of_Adjustmen…
Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health Across the Life Span
We developed and validated a synthetic cohort approach to examine numbers of cardiovascular risk factors (CRFs) and adverse clinical events, including incident cardiovascular disease and all-cause mortality, across the life span from ages 20 years to 90 years. Read the paper at https://academic.oup.com/aje/article/190/10/2208/6274861
Big data for big issues: Revealing travel patterns of low-income population based on smart card data mining in a global south unequal city
Smart card data (SCD) allow analyzing mobility at a fine level of detail, despite the remaining challenges such as identifying trip purpose. The use of the SCD may improve the understanding of transit users' travel patterns from precarious settlements areas, where the residents have historically limited access to opportunities and are usually underrepresented in surveys. Read the paper at https://
Replication of Oncology Randomized Trial Results using Swedish Registry Real World-Data: A Feasibility Study
Nationwide healthcare registries are potential important real-world data (RWD) sources for assessing drug effectiveness in oncology. However, it is unclear whether registry-derived RWD are suitable for clinical development. Read the paper at https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2424
Utilization of a National Registry to influence opioid prescribing behavior after hernia repair
Despite progress toward curtailing opioid prescribing, physicians are often slow to adopt new prescribing practices. Using the Abdominal Core Health Quality Collaborative (ACHQC), we aimed to demonstrate the ability of a national, disease-specific, personalized registry to impact opioid prescribing. Read the paper at https://link.springer.com/content/pdf/10.1007/s10029-021-02495-5.pdf
Accuracy of injury coding in a trauma registry
The overall accuracy of data held in the New Zealand Trauma Registry (NZTR) is suitable for quality improvement and benchmarking purposes, but more work is needed to improve the accuracy of individual cases, particularly those with head/neck and chest injury. Read the paper at https://journals.sagepub.com/doi/full/10.1177/14604086211041877
https://www.lupop.lu.se/article/accuracy-injury-coding-trauma-registry - 2025-12-14
Establishing an institutional reverse total shoulder arthroplasty registry
A well-managed institutional arthroplasty registry, including structured clinical and radiological follow-up assessments, offers the opportunity for high-quality long-term patient and arthroplasty outcome analysis. Such data are not only helpful for analyzing patient outcome and implant survival, but will be increasingly important to justify our daily clinical practice against different stakeholde
https://www.lupop.lu.se/article/establishing-institutional-reverse-total-shoulder-arthroplasty-registry - 2025-12-14
Looking beyond the numbers: quality assurance procedures in the Global Network for Women’s and Children’s Health Research Maternal Newborn Health Registry
We developed standardized QA processes for training, certification and supervision of the MNHR, a multisite research registry. It is expected that these activities, together with ongoing QA processes, will help to further optimize data quality for this protocol. Read the paper at https://reproductive-health-journal.biomedcentral.com/articles/10.1186/…
RESTORE: A Prospective Multinational Registry of Patients with Genetically Confirmed Spinal Muscular Atrophy - Rationale and Study Design
This registry will assess outcomes in patients with genetically confirmed SMA and provide information on the effectiveness and long-term safety of approved and emerging treatments. Read the paper at https://content.iospress.com/articles/journal-of-neuromuscular-diseases…
The effect of adjustment to register-based and questionnaire-based covariates on the association between air pollution and cardiometabolic disease
Our findings suggest that in studies of air pollution and cardiometabolic disease, which use an adjustment strategy with a broad range of register-based socioeconomic variables, there is no effect on risk estimates from subsequent lifestyle adjustment. Read the paper at https://www.sciencedirect.com/science/article/pii/S0013935121011816
Comprehensive registry of esophageal cancer in Japan, 2014
The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually. Read the paper at https://link.springer.com/article/10.1007%2Fs10388-021-00879-1
https://www.lupop.lu.se/article/comprehensive-registry-esophageal-cancer-japan-2014 - 2025-12-14
A Prospective Stroke Register in Sierra Leone: Demographics, Stroke Type, Stroke Care and Hospital Outcomes
Stroke is the second most common cause of adult death in Africa. This study reports the demographics, stroke types, stroke care and hospital outcomes for stroke in Freetown, Sierra Leone. Read the paper at https://www.frontiersin.org/articles/10.3389/fneur.2021.712060/full