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The complement system is an ancient component of the immune system, comprising three pathways: classical, lectin and alternative pathways. Central to these pathways is complement component C3, which converges the three pathways. C3 can be enzymatically cleaved into C3a which functions as an anaphylatoxin, and C3b, which functions as an opsonin. Previously, C3 was understood as a serum protein, how
