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CYP2C19 genotype has been shown to impact response to clopidogrel 75-mg but not prasugrel 10-mg. Here, we assessed effects of CYP2C19 metaboliser status on pharmacokinetics (PK) and pharmacodynamic (PD) responses to prasugrel 5-mg and 10-mg and clopidogrel 75-mg using data from two PK/PD studies in stable coronary artery disease (CAD) patients (GENERATIONS and FEATHER). Active metabolite concentra
Background: Concern has been raised regarding the mounting collective radiation doses from computed tomography (CT), increasing the risk of radiation-induced cancers in exposed populations. Purpose: To compare radiation dose and image quality in a chest phantom and in patients for the diagnosis of pulmonary embolism (PE) at 100 and 120 peak kilovoltage (kVp) using 16-multichannel detector computed
This article examines the expansive commercialization of various neospiritual and pseudoscientific practices currently mobilized in late modern Swedish pursuits of identity, meaning, and health. The focus is on the emergence and marketing of new entrepreneurs who have established themselves as “coaches” promoting personal development, and how they organize their own systems of education and certif
Popular Abstract in Swedish Mögel i byggnader är ett vanligt problem som kan orsaka en dålig innemiljö och påverka hälsan hos de personer som vistas i byggnaden. Kostnaderna för att åtgärda problemen kan vara omfattande. Att redan vid planeringsstadiet av en byggnad ta hänsyn till risker för mögelväxt kan leda till minskat antal mögelskador i framtiden och ett mer hållbart byggande. Mögelväxt är The susceptibility to mould growth varies between building materials. The factors that most affect mould growth, the relative humidity (RH) and temperature also vary in different parts of buildings. One way of preventing the growth of mould in buildings is therefore to choose building materials that can withstand the expected conditions. It is thus crucial that data are available to allow the corr
The core level photoemission and near edge X-ray photoabsorption spectra of guanine in the gas phase have been measured and the results interpreted with the aid of high level ab initio calculations. Tautomers are clearly identified spectroscopically, and their relative free energies and Boltzmann populations at the temperature of the experiment (600 K) have been calculated and compared with the ex
Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with ciclosporin, and assessment of MPA exposure is therefore necessary when reducing or stopping ciclosporin therapy. Here we report on the pharmacokinetic and pharmacodynamic behaviour of MPA in renal transplant patie
The title of the article: S’Villanorum de Malmøghae, refers to an inscription on a seal from a letter written in the year of 1350, sent by the council of Malmö to their colleagues in Rostock. The motif depicts a Romanesque church flanked by the moon and a star, and the inscription states that the letter was sent on behalf of the burghers of Malmö. The seal reveals a message that Malmö should be re
Redirection of organic waste, from landfilling or incineration, to biological treatment such as anaerobic digestion is of current interest in the Malmö-Copenhagen region. One type of waste that is expected to be suitable for anaerobic digestion is sludge from grease traps. Separate anaerobic digestion of this waste type and co-digestion with sewage sludge were evaluated. The methane potential was
Popular Abstract in Chinese 概括 II型糖尿病的發展趨勢在全世界範圍內非常迅速。我國目前有超過九千萬II型糖尿病患者，另外有大量血糖不正常的糖尿病高危人群。其中只有三成病人對自己的病情有所了解。II型糖尿病的病人與日俱增。 說到糖尿病，自然就會想到胰島素，以及血糖和胰島素的關系。胰島素是人體中非常重要的激素（荷爾蒙）。人體所需要的糖分主要是從食物中的澱粉類食物（米飯，面食）中來的，肉類也含有一部分的糖分。糖分從小腸吸收進入血液循環。胰島素的功能是讓身體細胞把血液中的糖分吸收進入細胞（比如肌肉細胞）加以使用，同時降低血液中的血糖成份。如果胰島素分泌不足，或者人體細胞對胰島素的敏感性降低會引起血糖升高，長期高血糖會損害血管和臟器的健康，最終導致糖尿病並發癥的發生。糖尿病並發癥是一種常見的慢性並發癥，後果相當嚴重，足部壞疽、腎功能衰竭、尿毒癥、視力模糊不清、失明、腦血Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. Clinical, animal and in vitro studies have revealed an association of the risk T-all
Popular Abstract in Swedish Ett grundantagande för avhandlingen Klassrummet som muntlig arena. Att bygga och etablera ethos är att en människa som med trovärdighet vill kunna verka som en demokratisk medborgare i olika kommunikationssituationer måste besitta kommunikativ kompetens. Följaktligen hänger demokrati och kommunikativ kompetens tätt samman. En viktig trovärdighetsfaktor i sammanhanget ärThe Class Room as an Oral Arena: Building and Establishing Ethos starts with the premise that every person who wants to act credibly as a democratic citizen must have a communicative competence. Democracy and communicative competence are closely linked. To communicate credibly is to communicate with ethos. The purpose of this dissertation is to study how students in Swedish gymnasium build and est
The challenge of managing radical innovation is partly about dealing with higher levels of uncertainty as organisations seek to extend their exploration into new technological and market spaces. Innovation management routines for dealing with this differ from those around incremental innovation — the well-established exploit/explore dilemma. But it can be argued that there is a second challenge as
NuoA is a small membrane spanning subunit of respiratory chain NADH:quinone oxidoreductase (complex I). Unlike the other complex I core protein subunits, the NuoA protein has no known homologue in other enzyme systems. The transmembrane orientation of NuoA cannot be unambiguously predicted, due to the small size of the polypeptide and the varying distribution of charged amino acid residues in NuoA
Saccharomyces cerevisiae alcohol dehydrogenases responsible for NADH-, and NADPH-specific reduction of the furaldehydes 5-hydroxymethyl-furfural (HMF) and furfural have previously been identified. In the present study, strains overexpressing the corresponding genes (mut-ADH1 and ADH6), together with a control strain, were compared in defined medium for anaerobic fermentation of glucose in the pres
The indoor climate in buildings has changed in the last decade due to more efficient climatic systems, floor heating systems and larger open floor areas with more natural light. All this has induced increasing ranges of relative humidity between different seasons. Also with decreasing relative humidity (in the winter 30-50% RH, in the summer 70-90% RH), floor-heating systems increase the temper
Following a royal act, a new academic discipline, Phonetics, was officially given birth in 1947. However, it was not until November 1950 that, at Lund University, Bertil Malmberg was appointed to the first Chair of Phonetics in Sweden. Four Scandinavian experts were chosen to evaluate Malmberg’s scientific competence. The peers produced four evaluations, which constitute the central corpus for th
We present the first multi-wavelength follow-up observations of two candidate gravitational-wave (GW) transient events recorded by LIGO and Virgo in their 2009-2010 science run. The events were selected with low latency by the network of GW detectors (within less than 10 minutes) and their candidate sky locations were observed by the Swift observatory (within 12 hr). Image transient detection was
