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Objective: Patients with RA treated with Janus kinase inhibitors (JAKis) are at increased risk of herpes zoster (HZ). The objective of this study was to investigate the serological immunogenicity and safety of the HZ subunit (HZ/su) vaccine in RA patients treated with JAKi, for which little is known. Methods: RA patients treated with JAKi (n = 82) at the Department of Rheumatology, Skåne Universit
A search for supersymmetry targeting the direct production of winos and higgsinos is conducted in final states with either two leptons (e or μ) with the same electric charge, or three leptons. The analysis uses 139 fb−1 of pp collision data at (Formula presented.) TeV collected with the ATLAS detector during Run 2 of the Large Hadron Collider. No significant excess over the Standard Model expectat
Pancreas-derived islet amyloid polypeptide (IAPP) aggregates and deposits in the pancreas and periphery of Type 2 Diabetes (T2D) patients, contributing to diabetic complications. The excess IAPP can be removed by autoantibodies, and increased levels of immunoglobulin (Ig) G against IAPP have been reported in T2D patients. However, whether other Ig classes are also affected and if the levels can be
A search for events with one top quark and missing transverse momentum in the final state is presented. The fully hadronic decay of the top quark is explored by selecting events with a reconstructed boosted top-quark topology produced in association with large missing transverse momentum. The analysis uses 139 fb−1 of proton-proton collision data at a centre-of-mass energy of s = 13 TeV recorded d
Background. Survivors of sepsis may experience long-term risk of increased morbidity and mortality, but estimations of cause-specific effects beyond 1 year after a sepsis episode are lacking. Method. This nationwide population-based cohort study linked data from national registers to compare patients aged ≥18 years in Sweden admitted to an intensive care unit from 2008 to 2019 with severe communit
Recent advancements in the integration of artificial intelligence (AI) and machine learning (ML) with physical sciences have led to significant progress in addressing complex phenomena governed by nonlinear partial differential equations (PDEs). This paper explores the application of novel operator learning methodologies to unravel the intricate dynamics of flame instability, particularly focusing
Background: Evidence for substance use-related problems in individuals with mild intellectual disability is sparse and mainly limited to selected psychiatric populations. We evaluated the risk of substance use-related problems in individuals with mild intellectual disability compared to the general population. Additionally, we have performed secondary sibling comparison analyses to account for fam
This paper deals with the component level breakdown of performance characteristics of a centrifugal compressor using detailed measurements. The compressor stage used for Heavy-Duty applications consisting of the impeller, vaneless diffuser, and volute has been experimentally tested in a gas stand. Several static pressure measurements combined with total pressure and temperature measurements on the
Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representa
Background/Aim: Anterior resection is the gold standard surgery for high and middle rectal tumors. In cases where anterior resection is not feasible, the surgeon resorts to a non-restorative approach such as Hartmann’s procedure or abdominoperineal resection. It is not well studied how Hartmann’s procedure impacts quality of life. This cross-sectional cohort study compares the long-term quality of
Transurethral resection of the prostate, or other methods to decrease outlet resistance usually leads to relief of symptoms in patients with bladder outlet obstruction (BOO). If symptoms of underactivity persist after normalization of outflow conditions, treatment options are limited. In this review, we hypothesize, based on results from basic research, what might become treatment options for such
Current gravitational wave (GW) detections rely on the existence of libraries of theoretical waveforms. Consequently, finding new physics with GWs requires libraries of nonstandard models, which are computationally demanding. We discuss how deep learning frameworks can be used to generate new waveforms "learned"from a simulation dataset obtained, say, from numerical relativity simulations. Concret
INTRODUCTION: Tau-positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods of analysis. METHODS: Using head-to-head data from five cohorts with tau PET radiotracers designed to target tau deposition in AD, we te
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has
The Freedom Theatre is one of the most remarkable institutions in occupied Palestine, and indeed the world. Nestled in Jenin refugee camp in the West Bank, the theatre has faced attacks, threats, imprisonment of many functionaries, and the assassination of its co-founder. And yet the theatre has not only endured, it has grown, from a provisional hall with rented plastic chairs to one of Palestine'The Freedom Theatre is one of the most remarkable institutions in occupied Palestine, and indeed the world. Nestled in Jenin refugee camp in the West Bank, the theatre has faced attacks, threats, imprisonment of many functionaries, and the assassination of its co-founder. And yet the theatre has not only endured, it has grown, from a provisional hall with rented plastic chairs to one of Palestine'
Applying research into assessments of community theatre, epidemiology, and young people's shared and private stories using a wide range of methodologies, this book explores the potential efficacy of community theatre to prevent the spread of HIV/AIDS in Tanzania with reference to several other comparable sites in Africa.Applying research into assessments of community theatre, epidemiology, and young people's shared and private stories using a wide range of methodologies, this book explores the potential efficacy of community theatre to prevent the spread of HIV/AIDS in Tanzania with reference to several other comparable sites in Africa.
Essentially all plasma membrane proteins are glycosylated, and their activity is regulated by tuning their cell surface dynamics. This is achieved by glycan-binding proteins of the galectin family that either retain glycoproteins within lattices or drive their endocytic uptake via the clathrin-independent glycolipid-lectin (GL-Lect) mechanism. Here, we have used immunofluorescence-based assays to
International collaboration is an important indicator of research excellence and quality. Not only is international collaboration necessary to maintain or strengthen competitiveness on individual, organisational and aggregated national levels, but it is also necessary to find solutions to global challenges and increase understanding between different countries and cultures.
This study reviews the literature on TOUCH to establish an analytical framework for the study of TOUCH in communication through language. Two questions are at the heart of the study—an ontological and a methodological one: What counts as TOUCH, and how can we investigate the way we talk about TOUCH? Within the broad framework of cognitive semantics, we offer a general approach to TOUCH and identif
Russia, Eurasia, and Eastern Europe remain an important hub for migration, with significant implications for both the societies in the region and migrants themselves. Migration can affect illiberal practices by contributing to political polarization, the adoption of restrictive immigration policies, the spread of xenophobia and discrimination, and economic competition. Global Migration and Illiber
