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Over the last few years, there has been a growing concern among academics and practitioners about the slow pace in which sustainability transformations unfold. While most socio-technical transformations tend to happen over extended periods, research shows that unless some dramatic changes are introduced, we are risking damaging the critical earth systems that sustain human life. In this context, u
Economic geographers have recently made important contributions to understanding of the relationship between regional transformation, industrial specialisation and innovation networks in the emergence of new industries. However, most contemporary research has focused on the influence of networks on regional trajectories, paying lip service to how regional trajectories also influence network config
We present a semi self-aligned processing scheme for III-V nanowire transistors with novel semiconductor spacers in the shape of Λ-ridges, utilising the effect of slow growth rate on {111}B facets. The addition of spacers relaxes the constraint on the perfect alignment of gate to contact areas to enable low overlap capacitances. The spacers give a field-plate effect that also helps reduce off-stat
Two sets of diesel injectors are tested in combination with common fuel additives in a multi-cylinder light-duty diesel engine. One set consists of new injectors and the other is aged by over 100,000 km use in a vehicle. Four fuels are tested with these injector sets to investigate the impact of fuel additives on combustion and emission characteristics. The results show that the aged injectors con
High-speed imaging of fuel sprays and combustion is conducted on a light-duty optical engine to investigate the effects of injector aging, with a focus on soot. The spray behaviors of one new and one aged injector are compared using Mie-scattering. In addition to this, the combustion process of a baseline diesel fuel and a blend with TPGME (tripropylene glycol monomethyl ether) are compared using
In this paper I want to examine some consequences that archival strategies of mass digitized environments might have on people’s relations to the history of recorded music. Archival strategies can make user-listeners connect tracks in surprising ways due to recommendation systems; they can make user-listeners get lost in the abundance of music; they can give user-listeners the impression that ther
PTCL patients exhibit poor survival with existing treatments. We investigated the efficacy of CHOP combined with alemtuzumab in 116 PTCL patients age 61–80 in an open-label, randomized phase 3 trial. Alemtuzumab was given on day 1, to a total of 360 mg in 21 patients, or 120 mg in 37. Hematotoxicity was increased with A-CHOP resulting in more grade ≥3 infections (40% versus 21%) and 4 versus 1 dea
Lifetimes of low-lying states in 73Ga and 70,72,74Zn were measured using the Recoil Distance Doppler Shift (RDDS) method. These nuclei were produced in deep-inelastic reactions in inverse kinematics with a 208Pb beam impinging on a 76Ge target. Prompt γ rays were detected using the AGATA tracking array coupled to the VAMOS++ spectrometer. Lifetime of the 5/2- state in 73Ga, measured for the first
Objective: Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH. Methods: We constructed one polygenic risk score (PRS) per lipid trait (total ch
Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non–muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity. Objective: NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC. Design, setting, and par
Intraosseous (IO) access is normally reserved for emergencies and critical care conditions when venous cannulation is not possible. Nonetheless, we present a case of IO insertion to a 56-year-old man, tetraplegic for many years due to progressive spinal muscular atrophy and with refractory suffering. The IO access was used for palliative sedation with propofol in a home care setting. The patient d
This paper examines the structural response of cold-formed steel-framed building lateral force-resisting systems under combinations of simulated earthquake and fire loading. Full-scale experiments with gypsum-sheet steel composite panel sheathed walls, oriented strand board sheathed walls, and steel strap braced walls are presented. Twenty-two test specimens are subjected sequentially to combinati
The aim of this study is to assess the effect that different fire exposures have on the behaviour of gypsum plasterboard assemblies with known fire resistance rating. For this purpose a series of fire tests were performed on commonly used wall assemblies. Four different small scale samples were tested under ISO 834 and HCC standard fire curves. Additionally, one assembly was tested in an enclosure
